AutismKB 2.0

Annotation Details for EIF4A3


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Basic Information Top
Gene Symbol:EIF4A3 ( DDX48,DKFZp686O16189,KIAA0111,MGC10862,NMP265,NUK34,eIF4AIII )
Gene Full Name: eukaryotic translation initiation factor 4A3
Band: 17q25.3
Quick LinksEntrez ID:9775; OMIM: 608546; Uniprot ID:IF4A3_HUMAN; ENSEMBL ID: ENSG00000141543; HGNC ID: 18683
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm10523622
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0016607IEA-nuclear speck-
GO:0030425IEA-dendrite-
GO:0035145IDA-exon-exon junction complex16601204
GO:0043025IEA-neuronal cell body-
GO:0071013IDA-catalytic step 2 spliceosome11991638
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003729IDA-mRNA binding22961380
GO:0004004IDA-ATP-dependent RNA helicase activity10523622
GO:0005515IPI-protein binding10523622
GO:0005524IDA-ATP binding10523622
GO:0008143IDA-poly(A) binding10523622
GO:0035368IEA-selenocysteine insertion sequence binding-
GO:0035613IEA-RNA stem-loop binding-
GO:0043021IEA-ribonucleoprotein complex binding-
GO ID Evidence Qualifier GO_term References
GO:0000184IMP-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay16209946
GO:0000184TAS-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-
GO:0000289TAS-nuclear-transcribed mRNA poly(A) tail shortening-
GO:0000398IC-mRNA splicing, via spliceosome11991638
GO:0000398TAS-mRNA splicing, via spliceosome-
GO:0006364IEA-rRNA processing-
GO:0006369TAS-termination of RNA polymerase II transcription-
GO:0006405TAS-RNA export from nucleus-
GO:0006406TAS-mRNA export from nucleus-
GO:0008306IEA-associative learning-
GO:0008380IBA-RNA splicing-
GO:0010501IBA-RNA secondary structure unwinding-
GO:0014070IEA-response to organic cyclic compound-
GO:0017148IDA-negative regulation of translation10523622
GO:0031124TAS-mRNA 3'-end processing-
GO:0035640IEA-exploration behavior-
GO:0045727IMP-positive regulation of translation18423201
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048026IEA-positive regulation of mRNA splicing, via spliceosome-
GO:0048701IMP-embryonic cranial skeleton morphogenesis24360810
GO:0072715IEA-cellular response to selenite ion-
GO:0090394IEA-negative regulation of excitatory postsynaptic potential-
GO:1904570IEA-negative regulation of selenocysteine incorporation-
GO:1904574IEA-negative regulation of selenocysteine insertion sequence binding-
GO:1990416IEA-cellular response to brain-derived neurotrophic factor stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF4A3TCEA211278117643375 Affinity Capture-MS
EIF4A3TCEA211511917643375 Affinity Capture-MS
SRRM1EIF4A311554416159877 Affinity Capture-MS
SRRM1EIF4A311511916159877 Affinity Capture-MS
SRRM2EIF4A311707116159877 Affinity Capture-MS
SRRM2EIF4A311511916159877 Affinity Capture-MS
C3orf19EIF4A311511916189514 Two-hybrid
C3orf19EIF4A311940216189514 Two-hybrid
OTUB1EIF4A312075118954305 Affinity Capture-MS
OTUB1EIF4A311511918954305 Affinity Capture-MS
UPF3BEIF4A312239619884259 Affinity Capture-Western; Co-fractionation
UPF3BEIF4A311511919884259 Affinity Capture-Western; Co-fractionation
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1923731
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-915'