AutismKB 2.0

Annotation Details for CUL7


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Basic Information Top
Gene Symbol:CUL7 ( KIAA0076,dJ20C7.5 )
Gene Full Name: cullin 7
Band: 6p21.1
Quick LinksEntrez ID:9820; OMIM: 609577; Uniprot ID:CUL7_HUMAN; ENSEMBL ID: ENSG00000044090; HGNC ID: 21024
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005680NAS-anaphase-promoting complex12481031
GO:0005737IDA-cytoplasm24793695
GO:0005794IDA-Golgi apparatus21572988
GO:0005813IDA-centrosome24793695
GO:0005829TAS-cytosol-
GO:0031467IDA-Cul7-RING ubiquitin ligase complex18498745
GO:0048471IDA-perinuclear region of cytoplasm21572988
GO:1990393IDA-3M complex24793695
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding17298945
GO:0031625IEA-ubiquitin protein ligase binding-
GO ID Evidence Qualifier GO_term References
GO:0000226IMP-microtubule cytoskeleton organization24793695
GO:0000281IMP-mitotic cytokinesis24793695
GO:0001570ISS-vasculogenesis-
GO:0001837IDA-epithelial to mesenchymal transition20139075
GO:0001890IDA-placenta development20139075
GO:0006508NAS-proteolysis12481031
GO:0006511IEA-ubiquitin-dependent protein catabolic process-
GO:0007030ISS-Golgi organization-
GO:0007088IMP-regulation of mitotic nuclear division24793695
GO:0016032IEA-viral process-
GO:0016567IDA-protein ubiquitination18498745
GO:0016567IEA-protein ubiquitination-
GO:0016567TAS-protein ubiquitination20139075
GO:0036498TAS-IRE1-mediated unfolded protein response-
GO:0043687TAS-post-translational protein modification-
GO:0050775IGI-positive regulation of dendrite morphogenesis21572988
GO:0050775ISS-positive regulation of dendrite morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CUL7SKP111239112481031 Affinity Capture-Western
CUL7SKP111515912481031 Affinity Capture-Western
CUL7TP5311301016547496 Affinity Capture-Western; Reconstituted Complex
CUL7TP5311515916547496 Affinity Capture-Western; Reconstituted Complex
RBX1CUL711530112481031 16142236 16547496 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RBX1CUL711515912481031 16142236 16547496 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
FBXW8CUL711764512481031 16142236 Affinity Capture-Western
FBXW8CUL711515912481031 16142236 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1913765
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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