AutismKB 2.0

Annotation Details for ARHGEF11


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Basic Information Top
Gene Symbol:ARHGEF11 ( DKFZp667F1223,GTRAP48,KIAA0380,PDZ-RHOGEF )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 11
Band: 1q23.1
Quick LinksEntrez ID:9826; OMIM: 605708; Uniprot ID:ARHGB_HUMAN; ENSEMBL ID: ENSG00000132694; HGNC ID: 14580
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IC-intracellular10026210
GO:0005737IDA-cytoplasm15755723
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO ID Evidence Qualifier GO_term References
GO:0001664IDA-G-protein coupled receptor binding15755723
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity10026210
GO:0005096IEA-GTPase activator activity-
GO:0005515IPI-protein binding10026210
GO ID Evidence Qualifier GO_term References
GO:0000910NAS-cytokinesis10026210
GO:0001558NAS-regulation of cell growth10026210
GO:0006928NAS-movement of cell or subcellular component10026210
GO:0006941NAS-striated muscle contraction10026210
GO:0007186IDA-G-protein coupled receptor signaling pathway15755723
GO:0007186TAS-G-protein coupled receptor signaling pathway10026210
GO:0007266IDA-Rho protein signal transduction10026210
GO:0030010NAS-establishment of cell polarity10026210
GO:0030036NAS-actin cytoskeleton organization10026210
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045893IDA-positive regulation of transcription, DNA-templated10026210
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARHGEF11RHOA11516410526156 Biochemical Activity; Reconstituted Complex
ARHGEF11RHOA10688010526156 Biochemical Activity; Reconstituted Complex
ARHGEF11CDC4210743320936779 Two-hybrid
ARHGEF11CDC4211516420936779 Two-hybrid
ARHGEF11GNA1210903010026210 Affinity Capture-Western
ARHGEF11GNA1211516410026210 Affinity Capture-Western
ARHGEF11PLXNB111516412123608 12183458 12220504 12730235 Affinity Capture-Western; Co-localization; Two-hybrid
ARHGEF11PLXNB111137712123608 12183458 12220504 12730235 Affinity Capture-Western; Co-localization; Two-hybrid
ARHGEF11PLXNB311516412123608 12183458 Affinity Capture-Western; Two-hybrid
ARHGEF11PLXNB311137812123608 12183458 Affinity Capture-Western; Two-hybrid
GNA13ARHGEF1111591410026210 Affinity Capture-Western
GNA13ARHGEF1111516410026210 Affinity Capture-Western
PLXNB2ARHGEF1111516412123608 12183458 Affinity Capture-Western; Two-hybrid
PLXNB2ARHGEF1111717812123608 12183458 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2441869
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070604-1'