AutismKB 2.0

Annotation Details for MELK


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Basic Information Top
Gene Symbol:MELK ( HPK38,KIAA0175 )
Gene Full Name: maternal embryonic leucine zipper kinase
Band: 9p13.2
Quick LinksEntrez ID:9833; OMIM: 607025; Uniprot ID:MELK_HUMAN; ENSEMBL ID: ENSG00000165304; HGNC ID: 16870
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005886IDA-plasma membrane21145462
GO:0005938IDA-cell cortex16159311
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity12400006
GO:0004715IDA-non-membrane spanning protein tyrosine kinase activity16216881
GO:0005509IDA-calcium ion binding16216881
GO:0005515IPI-protein binding12400006
GO:0005524IEA-ATP binding-
GO:0008289IEA-lipid binding-
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle12400006
GO:0000226IEA-microtubule cytoskeleton organization-
GO:0006915IDA-apoptotic process17280616
GO:0008283IDA-cell proliferation17280616
GO:0008631IEA-intrinsic apoptotic signaling pathway in response to oxidative stress-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030010IEA-establishment of cell polarity-
GO:0030097ISS-hemopoiesis-
GO:0035556IBA-intracellular signal transduction-
GO:0043065ISS-positive regulation of apoptotic process-
GO:0046777IDA-protein autophosphorylation16216881
GO:0061351ISS-neural precursor cell proliferation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MELKCDC25B11517112400006 Affinity Capture-Western; Reconstituted Complex
MELKCDC25B10742912400006 Affinity Capture-Western; Reconstituted Complex
ZNF622MELK12471711802789 Two-hybrid
ZNF622MELK11517111802789 Two-hybrid
C19orf62MELK11885519615732 Affinity Capture-MS
C19orf62MELK11517119615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:106924
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990603-5'