AutismKB 2.0

Annotation Details for ZEB2


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Basic Information Top
Gene Symbol:ZEB2 ( FLJ42816,KIAA0569,SIP-1,SIP1,SMADIP1,ZFHX1B )
Gene Full Name: zinc finger E-box binding homeobox 2
Band: 2q22.3
Quick LinksEntrez ID:9839; OMIM: 605802; Uniprot ID:ZEB2_HUMAN; ENSEMBL ID: ENSG00000169554; HGNC ID: 14881
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus24769727
GO:0005730IDA-nucleolus-
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0001205IEA-transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0001227IDA-transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding20516212
GO:0003677IEA-DNA binding-
GO:0005515IPI-protein binding26028330
GO:0019208NAS-phosphatase regulator activity11477103
GO:0046872IEA-metal ion binding-
GO:0070412IEA-R-SMAD binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter12837246
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter24769727
GO:0001755IEA-neural crest cell migration-
GO:0001756IEA-somitogenesis-
GO:0001843IEA-neural tube closure-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007399NAS-nervous system development11279515
GO:0021540IEA-corpus callosum morphogenesis-
GO:0021766IEA-hippocampus development-
GO:0021846IEA-cell proliferation in forebrain-
GO:0021957IEA-corticospinal tract morphogenesis-
GO:0030177IEA-positive regulation of Wnt signaling pathway-
GO:0043507IEA-positive regulation of JUN kinase activity-
GO:0045636ISS-positive regulation of melanocyte differentiation24769727
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter24769727
GO:0048023IC-positive regulation of melanin biosynthetic process24769727
GO:0048066ISS-developmental pigmentation24769727
GO:0048668IEA-collateral sprouting-
GO:0050772IEA-positive regulation of axonogenesis-
GO:0061373IEA-mammillary axonal complex development-
GO:0097324ISS-melanocyte migration24769727
GO:1902748IEA-positive regulation of lens fiber cell differentiation-
GO:1903056ISS-regulation of melanosome organization24769727
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ZEB2CEBPA11517517082780 Affinity Capture-MS
ZEB2CEBPA10747917082780 Affinity Capture-MS
ZEB2HDAC110931518182442 Affinity Capture-Western
ZEB2HDAC111517518182442 Affinity Capture-Western
ZEB2HDAC210931618182442 Affinity Capture-Western
ZEB2HDAC211517518182442 Affinity Capture-Western
ZEB2RBBP411186318182442 Affinity Capture-Western
ZEB2RBBP411517518182442 Affinity Capture-Western
ZEB2RBBP711186618182442 Affinity Capture-Western
ZEB2RBBP711517518182442 Affinity Capture-Western
ZEB2MTA111456218182442 Affinity Capture-Western
ZEB2MTA111517518182442 Affinity Capture-Western
ZEB2MTA211517518182442 Affinity Capture-Western
ZEB2MTA211465218182442 Affinity Capture-Western
COPS6ZEB211617616169070 Two-hybrid
COPS6ZEB211517516169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1344407
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070912-553'