AutismKB 2.0

Annotation Details for TLK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TLK1 ( KIAA0137,PKU-beta )
Gene Full Name: tousled-like kinase 1
Band: 2q31.1
Quick LinksEntrez ID:9874; OMIM: 608438; Uniprot ID:TLK1_HUMAN; ENSEMBL ID: ENSG00000198586; HGNC ID: 11841
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10523312
GO:0005634TAS-nucleus9427565
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity12660173
GO:0004674TAS-protein serine/threonine kinase activity9427565
GO:0005515IPI-protein binding25416956
GO:0005524IDA-ATP binding12660173
GO ID Evidence Qualifier GO_term References
GO:0001672IDA-regulation of chromatin assembly or disassembly12660173
GO:0006468IDA-protein phosphorylation12660173
GO:0006886IDA-intracellular protein transport10588641
GO:0006974IEA-cellular response to DNA damage stimulus-
GO:0007049IEA-cell cycle-
GO:0016569IEA-covalent chromatin modification-
GO:0035556IDA-intracellular signal transduction12660173
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TLK1AURKA11520617940067 Affinity Capture-Western; Biochemical Activity
TLK1AURKA11266617940067 Affinity Capture-Western; Biochemical Activity
TLK1YWHAE11336320936779 Two-hybrid
TLK1YWHAE11520620936779 Two-hybrid
TLK2TLK111620110523312 Affinity Capture-Western
TLK2TLK111520610523312 Affinity Capture-Western
TLK1TLK111520610523312 16189514 Biochemical Activity; Two-hybrid
ASF1BTLK112084511470414 17353931 Affinity Capture-MS; Biochemical Activity; Two-hybrid
ASF1BTLK111520611470414 17353931 Affinity Capture-MS; Biochemical Activity; Two-hybrid
ASF1ATLK111736811470414 16189514 17940067 Biochemical Activity; Two-hybrid
ASF1ATLK111520611470414 16189514 17940067 Biochemical Activity; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2441683
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-4933'