AutismKB 2.0

Annotation Details for MED12


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MED12 ( ARC240,CAGH45,FGS1,HOPA,KIAA0192,OKS,OPA1,TNRC11,TRAP230 )
Gene Full Name: mediator complex subunit 12
Band: Xq13.1
Quick LinksEntrez ID:9968; OMIM: 300188; Uniprot ID:MED12_HUMAN; ENSEMBL ID: ENSG00000184634; HGNC ID: 11957
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IEA-ubiquitin ligase complex-
GO:0005634IDA-nucleus10235267
GO:0005654TAS-nucleoplasm-
GO:0016020IDA-membrane19946888
GO:0016592IDA-mediator complex10198638
GO ID Evidence Qualifier GO_term References
GO:0000980IEA-RNA polymerase II distal enhancer sequence-specific DNA binding-
GO:0001104IDA-RNA polymerase II transcription cofactor activity10198638
GO:0001105IBA-RNA polymerase II transcription coactivator activity-
GO:0003682IEA-chromatin binding-
GO:0003712IDA-transcription cofactor activity12218053
GO:0003713IDA-transcription coactivator activity12037571
GO:0004872IDA-receptor activity12218053
GO:0005515IPI-protein binding21293490
GO:0008013IEA-beta-catenin binding-
GO:0008022IPI-protein C-terminus binding17000779
GO:0019904IPI-protein domain specific binding11984006
GO:0030374NAS-ligand-dependent nuclear receptor transcription coactivator activity10235266
GO:0042809NAS-vitamin D receptor binding10235266
GO:0046966IDA-thyroid hormone receptor binding10198638
GO:0061630IEA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0001843IEA-neural tube closure-
GO:0006367IDA-transcription initiation from RNA polymerase II promoter12218053
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0007492IEA-endoderm development-
GO:0007507IEA-heart development-
GO:0014003IEA-oligodendrocyte development-
GO:0014044IEA-Schwann cell development-
GO:0016567IEA-protein ubiquitination-
GO:0019827IEA-stem cell population maintenance-
GO:0021510IEA-spinal cord development-
GO:0030178IMP-negative regulation of Wnt signaling pathway17000779
GO:0030518IDA-intracellular steroid hormone receptor signaling pathway11867769
GO:0030521IDA-androgen receptor signaling pathway12218053
GO:0036342IEA-post-anal tail morphogenesis-
GO:0045893IDA-positive regulation of transcription, DNA-templated10198638
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12037571
GO:0048702IEA-embryonic neurocranium morphogenesis-
GO:0060070IEA-canonical Wnt signaling pathway-
GO:0060071IEA-Wnt signaling pathway, planar cell polarity pathway-
GO:0090245IEA-axis elongation involved in somitogenesis-
GO:1990403IEA-embryonic brain development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MED12CDK811529310198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED12CDK810745810198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED12LYST11529311984006 Two-hybrid
MED12LYST10755211984006 Two-hybrid
MED12ESR111529311867769 Affinity Capture-Western; Reconstituted Complex
MED12ESR110840311867769 Affinity Capture-Western; Reconstituted Complex
MED12ESR211529311867769 Reconstituted Complex
MED12ESR210840411867769 Reconstituted Complex
MED12GLI311529317000779 Reconstituted Complex; Two-hybrid
MED12GLI310899917000779 Reconstituted Complex; Two-hybrid
MED12MYC11529312660246 Reconstituted Complex
MED12MYC11069412660246 Reconstituted Complex
MED12MED111146515989967 Affinity Capture-MS; Affinity Capture-Western
MED12MED111529315989967 Affinity Capture-MS; Affinity Capture-Western
MED12SOX911254512136106 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MED12SOX911529312136106 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MED12SREBF111259810235267 Co-purification
MED12SREBF111529310235267 Co-purification
MED12THRA11529310198638 Affinity Capture-MS; Affinity Capture-Western
MED12THRA11292310198638 Affinity Capture-MS; Affinity Capture-Western
MED12VDR11326410198638 12837248 Affinity Capture-MS
MED12VDR11529310198638 12837248 Affinity Capture-MS
MED12TRRAP11390018418385 Co-purification
MED12TRRAP11529318418385 Co-purification
MED12SUPT3H11529317967894 Affinity Capture-Western
MED12SUPT3H11404217967894 Affinity Capture-Western
MED12MED2611529315175163 Affinity Capture-MS; Affinity Capture-Western
MED12MED2611483115175163 Affinity Capture-MS; Affinity Capture-Western
PPARGC1AMED1211529314636573 Affinity Capture-Western; Reconstituted Complex
PPARGC1AMED1211609714636573 Affinity Capture-Western; Reconstituted Complex
MED19MED1212855315175163 Affinity Capture-MS
MED19MED1211529315175163 Affinity Capture-MS
MED9MED1212040315175163 Affinity Capture-MS
MED9MED1211529315175163 Affinity Capture-MS
MED10MED1211529315175163 15989967 Affinity Capture-MS; Affinity Capture-Western
MED10MED1212397415175163 15989967 Affinity Capture-MS; Affinity Capture-Western
MED29MED1211529315175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED29MED1212073415175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED28MED1212321915175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED28MED1211529315175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED30MED1211529315989967 18691967 Affinity Capture-Western
MED30MED1212470715989967 18691967 Affinity Capture-Western
MED18MED1212015615989967 Reconstituted Complex
MED18MED1211529315989967 Reconstituted Complex
BRD4MED1211703616109376 Affinity Capture-MS
BRD4MED1211529316109376 Affinity Capture-MS
EHMT2MED1211529318691967 Affinity Capture-Western; Reconstituted Complex
EHMT2MED1211612318691967 Affinity Capture-Western; Reconstituted Complex
NANOGMED1211529319036726 Affinity Capture-Western; Two-hybrid
NANOGMED1212300019036726 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
MED12MED12_15G/T, MED12_23G/C, MED12_28A/C, MED12_6A/C, rs5030620 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1926212
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060125-1'