AutismKB 2.0

Annotation Details for RBX1


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Basic Information Top
Gene Symbol:RBX1 ( BA554C12.1,FLJ60363,MGC13357,MGC1481,RNF75,ROC1 )
Gene Full Name: ring-box 1, E3 ubiquitin protein ligase
Band: 22q13.2
Quick LinksEntrez ID:9978; OMIM: 603814; Uniprot ID:RBX1_HUMAN; ENSEMBL ID: ENSG00000100387,ENSG00000196236; HGNC ID: 9928
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0019005IDA-SCF ubiquitin ligase complex11956208
GO:0019005ISS-SCF ubiquitin ligase complex-
GO:0030891IEA-VCB complex-
GO:0031461IDA-cullin-RING ubiquitin ligase complex22405651
GO:0031462IDA-Cul2-RING ubiquitin ligase complex17636018
GO:0031463IDA-Cul3-RING ubiquitin ligase complex15983046
GO:0031464IDA-Cul4A-RING E3 ubiquitin ligase complex12732143
GO:0031465IDA-Cul4B-RING E3 ubiquitin ligase complex18794347
GO:0031466IDA-Cul5-RING ubiquitin ligase complex17636018
GO:0031467IDA-Cul7-RING ubiquitin ligase complex18498745
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity19028597
GO:0004842IDAcontributes_toubiquitin-protein transferase activity15983046
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11961546
GO:0008270IEA-zinc ion binding-
GO:0016874IEA-ligase activity-
GO:0019788IDA-NEDD8 transferase activity19250909
GO:0019788TAS-NEDD8 transferase activity-
GO:0031625IDA-ubiquitin protein ligase binding17636018
GO:0032403IEA-protein complex binding-
GO:0034450IDA-ubiquitin-ubiquitin ligase activity10230407
GO:0061630IDA-ubiquitin protein ligase activity10230407
GO:0061630TAS-ubiquitin protein ligase activity-
GO:0097602IDA-cullin family protein binding10230407
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000209TAS-protein polyubiquitination-
GO:0000715TAS-nucleotide-excision repair, DNA damage recognition-
GO:0000717TAS-nucleotide-excision repair, DNA duplex unwinding-
GO:0006283TAS-transcription-coupled nucleotide-excision repair-
GO:0006293TAS-nucleotide-excision repair, preincision complex stabilization-
GO:0006294TAS-nucleotide-excision repair, preincision complex assembly-
GO:0006295TAS-nucleotide-excision repair, DNA incision, 3'-to lesion-
GO:0006296TAS-nucleotide-excision repair, DNA incision, 5'-to lesion-
GO:0006513IDA-protein monoubiquitination22358839
GO:0010265TAS-SCF complex assembly-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016032IEA-viral process-
GO:0016055TAS-Wnt signaling pathway-
GO:0016567IDA-protein ubiquitination15103331
GO:0016567TAS-protein ubiquitination-
GO:0031146IDA-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process15103331
GO:0031146ISS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0033683TAS-nucleotide-excision repair, DNA incision-
GO:0042769TAS-DNA damage response, detection of DNA damage-
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process20389280
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043687TAS-post-translational protein modification-
GO:0045116IDA-protein neddylation19250909
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0070911TAS-global genome nucleotide-excision repair-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RBX1ACTG110658612481031 Affinity Capture-MS
RBX1ACTG111530112481031 Affinity Capture-MS
RBX1CCND111530111311237 Affinity Capture-Western
RBX1CCND110706711311237 Affinity Capture-Western
RBX1CCND211530111311237 Affinity Capture-Western
RBX1CCND210733411311237 Affinity Capture-Western
RBX1CCND311530111311237 Affinity Capture-Western
RBX1CCND310733611311237 Affinity Capture-Western
RBX1CDC3411530111675391 16123592 Affinity Capture-Western; Reconstituted Complex
RBX1CDC3410743211675391 16123592 Affinity Capture-Western; Reconstituted Complex
RBX1DDB111530115448697 16473935 16678110 Affinity Capture-MS; Affinity Capture-Western
RBX1DDB110800915448697 16473935 16678110 Affinity Capture-MS; Affinity Capture-Western
RBX1DDB211530116473935 Affinity Capture-Western
RBX1DDB210801016473935 Affinity Capture-Western
RBX1DIO211530115965468 Affinity Capture-Western
RBX1DIO210807815965468 Affinity Capture-Western
RBX1HSPA1A10953512481031 Affinity Capture-MS
RBX1HSPA1A11530112481031 Affinity Capture-MS
RBX1HSPA811530112481031 Affinity Capture-MS
RBX1HSPA810954412481031 Affinity Capture-MS
RBX1SMAD311530111359933 Affinity Capture-Western; Two-hybrid
RBX1SMAD311026311359933 Affinity Capture-Western; Two-hybrid
RBX1NEDD811530112481031 Affinity Capture-MS
RBX1NEDD811081512481031 Affinity Capture-MS
RBX1PSMA611530116759355 Affinity Capture-Western
RBX1PSMA611166016759355 Affinity Capture-Western
RBX1PTGS211530117429597 Affinity Capture-Western
RBX1PTGS211171517429597 Affinity Capture-Western
RBX1RPS6KB111530118279656 Affinity Capture-Western; Reconstituted Complex
RBX1RPS6KB111211218279656 Affinity Capture-Western; Reconstituted Complex
RBX1SKP111530112628165 15452136 16357137 Affinity Capture-Western; Reconstituted Complex
RBX1SKP111239112628165 15452136 16357137 Affinity Capture-Western; Reconstituted Complex
RBX1SKP211530118826954 Affinity Capture-Western
RBX1SKP211239318826954 Affinity Capture-Western
RBX1TCEB211530112048197 Affinity Capture-Western
RBX1TCEB211278512048197 Affinity Capture-Western
RBX1VHL11530112048197 12604794 16325183 17353931 Affinity Capture-MS; Affinity Capture-Western
RBX1VHL11326912048197 12604794 16325183 17353931 Affinity Capture-MS; Affinity Capture-Western
RBX1CUL511530110230407 11861641 18805092 Affinity Capture-Western; Co-crystal Structure; Two-hybrid
RBX1CUL511374310230407 11861641 18805092 Affinity Capture-Western; Co-crystal Structure; Two-hybrid
RBX1GAN11380015983046 Affinity Capture-Western
RBX1GAN11530115983046 Affinity Capture-Western
RBX1CUL4B11530112481031 Affinity Capture-MS
RBX1CUL4B11402812481031 Affinity Capture-MS
RBX1CUL4A11402910230407 11861641 12481031 15448697 18593899 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
RBX1CUL4A11530110230407 11861641 12481031 15448697 18593899 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
RBX1CUL311530111861641 12481031 15448697 15601839 Affinity Capture-MS; Affinity Capture-Western
RBX1CUL311403011861641 12481031 15448697 15601839 Affinity Capture-MS; Affinity Capture-Western
RBX1CUL211530110230407 11861641 12481031 15448697 17183367 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBX1CUL211403110230407 11861641 12481031 15448697 17183367 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBX1CUL111403210230407 11483504 11861641 11956208 11961546 12481031 12609982 12706828 15448697 16123592 16759355 18826954 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Two-hybrid
RBX1CUL111530110230407 11483504 11861641 11956208 11961546 12481031 12609982 12706828 15448697 16123592 16759355 18826954 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Two-hybrid
RBX1ENC111530115983046 Affinity Capture-Western
RBX1ENC111407915983046 Affinity Capture-Western
RBX1KEAP111530115983046 Affinity Capture-Western
RBX1KEAP111515615983046 Affinity Capture-Western
RBX1CUL711530112481031 16142236 16547496 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RBX1CUL711515912481031 16142236 16547496 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
FBXO18RBX111530111956208 15118074 Affinity Capture-Western; Reconstituted Complex
FBXO18RBX112433311956208 15118074 Affinity Capture-Western; Reconstituted Complex
TUBA1BRBX111530112481031 Affinity Capture-MS
TUBA1BRBX111565112481031 Affinity Capture-MS
FBXO22RBX111530112481031 Affinity Capture-MS
FBXO22RBX111764912481031 Affinity Capture-MS
FBXO3RBX111530112481031 Affinity Capture-MS
FBXO3RBX111765712481031 Affinity Capture-MS
FBXW8RBX111530112481031 Affinity Capture-Western
FBXW8RBX111764512481031 Affinity Capture-Western
CAND1RBX111530112609982 18826954 Affinity Capture-MS; Affinity Capture-Western
CAND1RBX112093712609982 18826954 Affinity Capture-MS; Affinity Capture-Western
DET1RBX111530114739464 Affinity Capture-Western
DET1RBX112038714739464 Affinity Capture-Western
RFWD2RBX111530114739464 Affinity Capture-Western
RFWD2RBX112213614739464 Affinity Capture-Western
KBTBD10RBX111530115983046 Affinity Capture-Western
KBTBD10RBX111560715983046 Affinity Capture-Western
ZC3HC1RBX111530116009132 Affinity Capture-Western
ZC3HC1RBX111959216009132 Affinity Capture-Western
FBXO31RBX111530116357137 Affinity Capture-Western
FBXO31RBX112289016357137 Affinity Capture-Western
PGAM5RBX111530117046835 Affinity Capture-Western
PGAM5RBX112815417046835 Affinity Capture-Western
FBXO11RBX111530117098746 Affinity Capture-Western
FBXO11RBX112317317098746 Affinity Capture-Western
ABTB2RBX111530118429817 Affinity Capture-Western
ABTB2RBX111736718429817 Affinity Capture-Western
DCUN1D1RBX111992018826954 Affinity Capture-Western; Reconstituted Complex
DCUN1D1RBX111530118826954 Affinity Capture-Western; Reconstituted Complex
ARID1BRBX111530120086098 Affinity Capture-Western
ARID1BRBX112155920086098 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
RBX1CUL54996814564014 Rbx1 interacts with Cul5.
RBX1CUL15027111956208 CUL1 interacts with ROC1.
RBX1CUL15434111961546 Rbx1 interacts with Cul1 [411-776] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041008-106'