AutismKB 2.0

Annotation Details for CDH1


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Basic Information Top
Gene Symbol:CDH1 ( Arc-1,CD324,CDHE,ECAD,LCAM,UVO )
Gene Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Band: 16q22.1
Quick LinksEntrez ID:999; OMIM: 192090; Uniprot ID:CADH1_HUMAN; ENSEMBL ID: ENSG00000039068; HGNC ID: 1748
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005768IEA-endosome-
GO:0005802IMP-trans-Golgi network17620337
GO:0005886TAS-plasma membrane-
GO:0005913IDA-cell-cell adherens junction16338932
GO:0009898IDA-cytoplasmic side of plasma membrane20189993
GO:0015629IDA-actin cytoskeleton16338932
GO:0016021IDA-integral component of membrane16338932
GO:0016328IDA-lateral plasma membrane16338932
GO:0016342IDA-catenin complex18593713
GO:0016600IDA-flotillin complex24046456
GO:0030027IDA-lamellipodium24046456
GO:0030054IDA-cell junction19038973
GO:0030054TAS-cell junction17047063
GO:0030864IDAcolocalizes_withcortical actin cytoskeleton24046456
GO:0043296IDA-apical junction complex10460003
GO:0048471IDA-perinuclear region of cytoplasm16338932
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0001948IPI-glycoprotein binding23086448
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding11401320
GO:0008013IDA-beta-catenin binding17620337
GO:0030506IPI-ankyrin binding17620337
GO:0032794IPI-GTPase activating protein binding20116244
GO:0045295IPI-gamma-catenin binding1639850
GO:0045296IDA-cadherin binding25468996
GO:0050839IPI-cell adhesion molecule binding21724833
GO:0050839NAS-cell adhesion molecule binding16338932
GO ID Evidence Qualifier GO_term References
GO:0007156NAS-homophilic cell adhesion via plasma membrane adhesion molecules8033105
GO:0007416IEA-synapse assembly-
GO:0009636IEA-response to toxic substance-
GO:0016337IDA-single organismal cell-cell adhesion16338932
GO:0021983IEA-pituitary gland development-
GO:0022408IMP-negative regulation of cell-cell adhesion19653274
GO:0022617TAS-extracellular matrix disassembly-
GO:0030198TAS-extracellular matrix organization-
GO:0031175IEA-neuron projection development-
GO:0034332IMP-adherens junction organization21724833
GO:0034332TAS-adherens junction organization-
GO:0035635TAS-entry of bacterium into host cell-
GO:0042493IEA-response to drug-
GO:0042993IDA-positive regulation of transcription factor import into nucleus16338932
GO:0045893IDA-positive regulation of transcription, DNA-templated16338932
GO:0071285IDA-cellular response to lithium ion12937339
GO:0071681IDA-cellular response to indole-3-methanol10868478
GO:0072659IDA-protein localization to plasma membrane17620337
GO:0090002IMP-establishment of protein localization to plasma membrane20859650
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDH1ACTG11065869535896 Affinity Capture-Western
CDH1ACTG11074349535896 Affinity Capture-Western
CDH1ACTN11066029535896 Affinity Capture-Western
CDH1ACTN11074349535896 Affinity Capture-Western
CDH1CA910722314567991 Affinity Capture-Western
CDH1CA910743414567991 Affinity Capture-Western
CDH1CDC2710743112956947 16479161 Affinity Capture-Western; Reconstituted Complex
CDH1CDC2710743412956947 16479161 Affinity Capture-Western; Reconstituted Complex
JUPCDH11099311639850 7542250 8074697 8207061 9535896 Affinity Capture-Western; Reconstituted Complex
JUPCDH11074341639850 7542250 8074697 8207061 9535896 Affinity Capture-Western; Reconstituted Complex
CTNNA1CDH11078767542250 8227214 9233779 10381631 11960376 Affinity Capture-Western
CTNNA1CDH11074347542250 8227214 9233779 10381631 11960376 Affinity Capture-Western
CTNNB1CDH11078807542250 7876318 7954478 8227214 9233779 9405455 9535896 9819408 10381631 10772923 11113628 11245482 11254878 11348595 11712088 11960376 12061792 12169098 12634428 12640114 12830000 15023525 18593907 Affinity Capture-Western; Co-crystal Structure
CTNNB1CDH11074347542250 7876318 7954478 8227214 9233779 9405455 9535896 9819408 10381631 10772923 11113628 11245482 11254878 11348595 11712088 11960376 12061792 12169098 12634428 12640114 12830000 15023525 18593907 Affinity Capture-Western; Co-crystal Structure
CTNND1CDH11078817542250 7651399 7876318 9535896 10409703 12427869 12640114 12707304 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CTNND1CDH11074347542250 7651399 7876318 9535896 10409703 12427869 12640114 12707304 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VCLCDH11132579405455 9535896 Affinity Capture-Western
VCLCDH11074349405455 9535896 Affinity Capture-Western
CDH1CDH110743410202138 10910767 Affinity Capture-Western; Co-purification; Reconstituted Complex
EZRCDH111327110462524 Affinity Capture-Western
EZRCDH110743410462524 Affinity Capture-Western
IQGAP1CDH111435310608854 Affinity Capture-Western; Reconstituted Complex
IQGAP1CDH110743410608854 Affinity Capture-Western; Reconstituted Complex
PSEN1CDH111164210635315 16126725 Affinity Capture-Western
PSEN1CDH110743410635315 16126725 Affinity Capture-Western
SRCCDH111259210744074 Affinity Capture-Western
SRCCDH110743410744074 Affinity Capture-Western
MAGI1CDH111465510772923 Affinity Capture-Western
MAGI1CDH110743410772923 Affinity Capture-Western
CDH3CDH110743610910767 Affinity Capture-Western; Co-purification
CDH3CDH110743410910767 Affinity Capture-Western; Co-purification
EGFRCDH110743410969083 Affinity Capture-Western
EGFRCDH110827610969083 Affinity Capture-Western
MYO7ACDH111073111080149 Affinity Capture-Western
MYO7ACDH110743411080149 Affinity Capture-Western
VEZTCDH112073611080149 Affinity Capture-Western
VEZTCDH110743411080149 Affinity Capture-Western
GNA13CDH111591411136230 Reconstituted Complex
GNA13CDH110743411136230 Reconstituted Complex
GNA12CDH110903011136230 Reconstituted Complex
GNA12CDH110743411136230 Reconstituted Complex
METCDH110743411254878 Affinity Capture-Western
METCDH111039111254878 Affinity Capture-Western
MAD2L2CDH111572211459826 Reconstituted Complex
MAD2L2CDH110743411459826 Reconstituted Complex
CBLL1CDH110743411836526 16336960 Affinity Capture-Western; Two-hybrid
CBLL1CDH112296011836526 16336960 Affinity Capture-Western; Two-hybrid
ARPC2CDH111541511882288 Affinity Capture-Western
ARPC2CDH110743411882288 Affinity Capture-Western
CSE1LCDH110782112061792 Affinity Capture-Western
CSE1LCDH110743412061792 Affinity Capture-Western
ITGAECDH110988812434297 Co-purification
ITGAECDH110743412434297 Co-purification
PKP4CDH111407412615965 Two-hybrid
PKP4CDH110743412615965 Two-hybrid
CDONCDH111916512634428 Affinity Capture-Western
CDONCDH110743412634428 Affinity Capture-Western
BOCCDH110743412634428 Affinity Capture-Western
BOCCDH112485912634428 Affinity Capture-Western
RAB8BCDH111971912639940 Affinity Capture-Western
RAB8BCDH110743412639940 Affinity Capture-Western
FYNCDH110743412640114 Affinity Capture-Western; Reconstituted Complex
FYNCDH110881012640114 Affinity Capture-Western; Reconstituted Complex
FERCDH110853212640114 Reconstituted Complex
FERCDH110743412640114 Reconstituted Complex
YES1CDH111335712640114 Reconstituted Complex
YES1CDH110743412640114 Reconstituted Complex
APC2CDH110743412956947 Affinity Capture-Western; Reconstituted Complex
CDC26CDH110743412956947 Reconstituted Complex
CDC26CDH112887812956947 Reconstituted Complex
ANAPC4CDH111898212956947 Reconstituted Complex
ANAPC4CDH110743412956947 Reconstituted Complex
ANAPC7CDH111953812956947 Reconstituted Complex
ANAPC7CDH110743412956947 Reconstituted Complex
ANAPC11CDH111959112956947 Reconstituted Complex
ANAPC11CDH110743412956947 Reconstituted Complex
ANAPC1CDH112222912956947 Reconstituted Complex
ANAPC1CDH110743412956947 Reconstituted Complex
CDC23CDH111424212956947 Reconstituted Complex
CDC23CDH110743412956947 Reconstituted Complex
CDC16CDH111440012956947 Reconstituted Complex
CDC16CDH110743412956947 Reconstituted Complex
AJAP1CDH112101214595118 Affinity Capture-Western
AJAP1CDH110743414595118 Affinity Capture-Western
USP9XCDH111386714742711 Co-fractionation
USP9XCDH110743414742711 Co-fractionation
NEDD9CDH111081615144564 Affinity Capture-Western; Reconstituted Complex
NEDD9CDH110743415144564 Affinity Capture-Western; Reconstituted Complex
HDAC1CDH110743415388328 Affinity Capture-Western; Co-purification
HDAC1CDH110931515388328 Affinity Capture-Western; Co-purification
HDAC2CDH110931615388328 Affinity Capture-Western; Co-purification
HDAC2CDH110743415388328 Affinity Capture-Western; Co-purification
CREBBPCDH110777716319895 Affinity Capture-Western
CREBBPCDH110743416319895 Affinity Capture-Western
EP300CDH110834716319895 Affinity Capture-Western
EP300CDH110743416319895 Affinity Capture-Western
ADAM9CDH111429016336960 Affinity Capture-Western
ADAM9CDH110743416336960 Affinity Capture-Western
PTTG1CDH111466316479161 Affinity Capture-Western
PTTG1CDH110743416479161 Affinity Capture-Western
UBCCDH111316416751808 16980628 18624796 Affinity Capture-Western
UBCCDH110743416751808 16980628 18624796 Affinity Capture-Western
MDM2CDH111035816980628 Affinity Capture-Western; Reconstituted Complex
MDM2CDH110743416980628 Affinity Capture-Western; Reconstituted Complex
FOXM1CDH110743418758239 Affinity Capture-Western
FOXM1CDH110859418758239 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88354
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010606-1'