AutismKB 2.0

Annotation Details for CASP8AP2


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Basic Information Top
Gene Symbol:CASP8AP2 ( CED-4,FLASH,FLJ11208,KIAA1315,RIP25 )
Gene Full Name: caspase 8 associated protein 2
Band: 6q15
Quick LinksEntrez ID:9994; OMIM: 606880; Uniprot ID:C8AP2_HUMAN; ENSEMBL ID: ENSG00000118412; HGNC ID: 1510
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus12477726
GO:0005737IDA-cytoplasm12477726
GO:0005739IDA-mitochondrion17245429
GO:0016605IDA-PML body17245429
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003714IDA-transcription corepressor activity12477726
GO:0005123TAS-death receptor binding10235259
GO:0005515IPI-protein binding12477726
GO:0008656ISS-cysteine-type endopeptidase activator activity involved in apoptotic process-
GO:0016505ISS-peptidase activator activity involved in apoptotic process-
GO:0032184IDA-SUMO polymer binding23086935
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006919IMP-activation of cysteine-type endopeptidase activity involved in apoptotic process17245429
GO:0006919ISS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0007049IEA-cell cycle-
GO:0007165TAS-signal transduction10235259
GO:0008625IMP-extrinsic apoptotic signaling pathway via death domain receptors17245429
GO:0008625ISS-extrinsic apoptotic signaling pathway via death domain receptors-
GO:0036337IMP-Fas signaling pathway17245429
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0097190TAS-apoptotic signaling pathway10235259
GO:1903507IEA-negative regulation of nucleic acid-templated transcription-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CASP8AP2FAS10685110235259 Affinity Capture-Western
CASP8AP2FAS11531510235259 Affinity Capture-Western
CASP8AP2CASP811531510235259 Affinity Capture-Western
CASP8AP2CASP810729110235259 Affinity Capture-Western
CASP8AP2GLUL11531520936779 Two-hybrid
CASP8AP2GLUL10901420936779 Two-hybrid
CASP8AP2SREBF211531520936779 Two-hybrid
CASP8AP2SREBF211259920936779 Two-hybrid
CASP8AP2TRAF211531511340079 Affinity Capture-Western; Reconstituted Complex
CASP8AP2TRAF211303811340079 Affinity Capture-Western; Reconstituted Complex
CASP8AP2UBE2I11531520936779 Two-hybrid
CASP8AP2UBE2I11317720936779 Two-hybrid
CASP8AP2FADD11531510235259 Affinity Capture-Western
CASP8AP2FADD11430210235259 Affinity Capture-Western
CASP8AP2CASP8AP211531510235259 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1349399
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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