Annotation Detail for NAT2
Basic Information Top
| Gene Symbol: | NAT2 ( AAC2,PNAT ) |
|---|---|
| Gene Full Name: | N-acetyltransferase 2 (arylamine N-acetyltransferase) |
| Band: | 8p22 |
| Quick Links | Entrez ID:10; OMIM: 612182; Uniprot ID:ARY2_HUMAN; ENSEMBL ID: ENSG00000156006; HGNC ID: 7646 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Desease ID | Desease Name |
|---|---|
| 1709 | Parkinson disease |
| 1728 | Gastrointestinal tumor |
| 1740 | Alzheimer's disease |
| 1781 | Rheumatoid arthritis |
| 1804 | Chronic obstructive airway disease |
| 1901 | Endometriosis |
| 1904 | Diabetes mellitus |
| 1934 | Cancer |
| 1998 | Enteritis |
| 2044 | Pre-Eclampsia |
| 2146 | Lupus erythematosus |
| 2196 | Periodontal disease |
| 2220 | Dermatitis |
| Desease Name |
|---|
| rheumatoid arthritis |
| periodontitis |
| Parkinson's disease |
| Contact Sensitisation |
| colorectal cancer |
| endometriosis |
| prostate cancer |
| CANCER |
| stomach cancer |
| laryngeal cancer |
| ulcerative colitis |
| nasopharyngeal cancer |
| sulfasalazine, adverse effects of |
| Asthma |
| bladder cancer |
| breast cancer |
| Haematological Neoplasias |
| asbestos-associated pulmonary disorders |
| IMMUNE |
| NEUROLOGICAL |
| urinary mutagenicity |
| METABOLIC |
| cholangiocarcinoma |
| urinary bladder cancer |
| lung cancer |
| Crohn's disease |
| REPRODUCTION |
| plasma glucose concentration |
| Cell Cancer |
| cervical cancer |
| cytogenetic studies |
| No data |
| Desease Name |
|---|
| Acetylation, slow |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C015262 | 1,6-hexamethylene diisocyanate | NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate | increases response to substance | 11927838 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | NAT2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | increases activity | 15110095 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | NAT2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | increases activity | 15110095 |
| C017821 | 2-amino-3-methyl-9H-pyrido(2,3-b)indole | NAT2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole | increases activity | 14729582 |
| C012177 | 2-aminofluorene | NAT2 protein polymorphism results in increased acetylation of 2-aminofluorene | increases acetylation | 14722254 |
| C012177 | 2-aminofluorene | NAT2 protein results in increased acetylation of 2-aminofluorene | increases acetylation | 14722254 |
| C012177 | 2-aminofluorene | NAT2 protein results in increased acetylation of 2-aminofluorene | increases acetylation | 16003948 15627487 |
| C012177 | 2-aminofluorene | NAT2 protein results in increased metabolism of 2-aminofluorene | increases metabolic processing | 16815960 |
| C003898 | 2-anisidine | NAT2 protein results in increased activity of 2-anisidine | increases activity | 15450435 |
| C075748 | 2-(bromoacetylamino)fluorene | 2-(bromoacetylamino)fluorene binds to NAT2 protein | affects binding | 15106881 |
| C014464 | 3,4-dichloroaniline | NAT2 protein results in increased acetylation of 3,4-dichloroaniline | increases acetylation | 15627487 |
| C014464 | 3,4-dichloroaniline | NAT2 protein results in increased acetylation of 3,4-dichloroaniline | increases acetylation | 15627487 |
| C026137 | 3-hydroxyacetanilide | 3-hydroxyacetanilide results in decreased expression of NAT2 mRNA | decreases expression | 18544908 |
| C117220 | 3-nitrobenzanthrone | NAT2 protein results in increased activity of 3-nitrobenzanthrone | increases activity | 15805261 |
| C009505 | 4,4'-diaminodiphenylmethane | NAT2 gene polymorphism affects the acetylation of 4,4'-diaminodiphenylmethane | affects acetylation | 16192314 |
| C009505 | 4,4'-diaminodiphenylmethane | NAT2 gene polymorphism results in increased susceptibility to 4,4'-diaminodiphenylmethane | increases response to substance | 16192314 |
| C009505 | 4,4'-diaminodiphenylmethane | NAT2 protein results in increased acetylation of 4,4'-diaminodiphenylmethane | increases acetylation | 16192314 |
| C005969 | 4,4'-diphenylmethane diisocyanate | NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate | increases response to substance | 11927838 |
| C013813 | 4-anisidine | NAT2 protein results in increased acetylation of 4-anisidine | increases acetylation | 15627487 |
| C006757 | 4-biphenylamine | NAT2 protein results in increased activity of 4-biphenylamine | increases activity | 15450435 |
| C006757 | 4-biphenylamine | NAT2 protein results in increased acetylation of 4-biphenylamine | increases acetylation | 16482518 |
| C006757 | 4-biphenylamine | NAT2 protein results in increased metabolism of 4-biphenylamine | increases metabolic processing | 16815960 16857729 |
| C023621 | 4-bromoaniline | NAT2 protein results in increased acetylation of 4-bromoaniline | increases acetylation | 15627487 |
| C023621 | 4-bromoaniline | NAT2 protein results in increased acetylation of 4-bromoaniline | increases acetylation | 15627487 |
| C004658 | 4-chloroaniline | NAT2 protein results in increased acetylation of 4-chloroaniline | increases acetylation | 15627487 |
| C004658 | 4-chloroaniline | NAT2 protein results in increased acetylation of 4-chloroaniline | increases acetylation | 15627487 |
| C072825 | 4-hexyloxyaniline | NAT2 protein results in increased acetylation of 4-hexyloxyaniline | increases acetylation | 15627487 |
| C072825 | 4-hexyloxyaniline | NAT2 protein results in increased acetylation of 4-hexyloxyaniline | increases acetylation | 15627487 |
| C013067 | 4-iodoaniline | NAT2 protein results in increased acetylation of 4-iodoaniline | increases acetylation | 15627487 |
| C013067 | 4-iodoaniline | NAT2 protein results in increased acetylation of 4-iodoaniline | increases acetylation | 15627487 |
| C008642 | 4-nitrophenyl acetate | NAT2 protein results in increased acetylation of 4-nitrophenyl acetate | increases acetylation | 15209520 |
| C029728 | 4-phenylenediamine | NAT2 gene polymorphism affects the susceptibility to 4-phenylenediamine | affects response to substance | 16533241 |
| C421010 | 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole | NAT2 protein affects the metabolism of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole | affects metabolic processing | 17067997 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of NAT2 mRNA | affects expression | 17562736 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of NAT2 mRNA | decreases expression | 18544908 |
| D000588 | Amines | NAT2 protein affects the metabolism of and results in increased activity of Amines | affects metabolic processing|increases activity | 12505289 |
| D000588 | Amines | NAT2 protein results in decreased activity of Amines | decreases activity | 15613766 |
| D000588 | Amines | NAT2 protein results in increased acetylation of Amines | increases acetylation | 15122594 |
| D000588 | Amines | NAT2 protein results in increased activity of Amines | increases activity | 15700302 |
| D010129 | 4-Aminobenzoic Acid | NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid | increases acetylation | 16003948 16482518 15627487 |
| D010129 | 4-Aminobenzoic Acid | NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid | increases acetylation | 15627487 |
| D015081 | 2-Naphthylamine | NAT2 protein results in increased activity of 2-Naphthylamine | increases activity | 15450435 |
| D019804 | Mesalamine | NAT2 protein results in increased acetylation of Mesalamine | increases acetylation | 15627487 |
| D019804 | Mesalamine | NAT2 protein results in increased acetylation of Mesalamine | increases acetylation | 15627487 |
| D010131 | Aminosalicylic Acid | NAT2 protein results in increased acetylation of Aminosalicylic Acid | increases acetylation | 16003948 15627487 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of NAT2 mRNA | affects expression | 16483693 |
| C023650 | aniline | NAT2 protein results in increased acetylation of aniline | increases acetylation | 15627487 |
| D000814 | Aniline Compounds | NAT2 protein results in increased acetylation of Aniline Compounds analog | increases acetylation | 15627487 |
| D001194 | Asbestos | NAT2 protein polymorphism affects the susceptibility to Asbestos | affects response to substance | 15993904 |
| D001554 | Benzene | NAT2 gene polymorphism affects the susceptibility to Benzene | affects response to substance | 15226677 |
| D001554 | Benzene | NAT2 gene polymorphism results in increased susceptibility to Benzene | increases response to substance | 15226677 |
| D001554 | Benzene | NAT2 protein affects the metabolism of Benzene | affects metabolic processing | 15226677 |
| C029876 | benzidine | NAT2 gene polymorphism affects the susceptibility to benzidine | affects response to substance | 16003747 |
| C056005 | bromoacetanilide | bromoacetanilide results in decreased activity of and results in increased alkylation of NAT2 protein | decreases activity|increases alkylation | 15106881 |
| D002110 | Caffeine | NAT2 protein affects the metabolism of Caffeine | affects metabolic processing | 15980104 14586387 14586384 15327588 14747882 15199075 |
| D002110 | Caffeine | NAT2 protein results in increased acetylation of Caffeine | increases acetylation | 15558239 |
| D002220 | Carbamazepine | Carbamazepine results in increased expression of NAT2 mRNA | increases expression | 17112801 |
| D002338 | Carotenoids | NAT2 protein polymorphism affects the susceptibility to Carotenoids | affects response to substance | 15095308 |
| D002753 | Chlorzoxazone | NAT2 protein affects the metabolism of Chlorzoxazone | affects metabolic processing | 14586387 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of NAT2 mRNA | decreases expression | 20106945 |
| D003622 | Dapsone | NAT2 protein results in increased acetylation of Dapsone | increases acetylation | 14528063 |
| D003622 | Dapsone | NAT2 protein results in increased metabolism of Dapsone | increases metabolic processing | 15999287 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone results in decreased expression of NAT2 mRNA | decreases expression | 18709148 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of NAT2 mRNA | increases expression | 11323195 |
| C010920 | dihydrofolate | dihydrofolate results in decreased activity of NAT2 protein | decreases activity | 16003948 |
| C007366 | erythritol anhydride | NAT2 gene polymorphism results in decreased susceptibility to erythritol anhydride | decreases response to substance | 17078101 |
| D004958 | Estradiol | Estradiol results in decreased expression of NAT2 mRNA | decreases expression | 20106945 |
| D004958 | Estradiol | Estradiol results in decreased expression of NAT2 mRNA | decreases expression | 18709148 |
| D015073 | 2-Acetylaminofluorene | NAT2 protein results in increased activity of 2-Acetylaminofluorene | increases activity | 15450435 |
| D005492 | Folic Acid | Folic Acid results in decreased activity of NAT2 protein | decreases activity | 16003948 |
| D005492 | Folic Acid | Folic Acid results in decreased activity of NAT2 protein modified form | decreases activity | 16003948 |
| D005492 | Folic Acid | NAT2 protein results in increased acetylation of Folic Acid metabolite | increases acetylation | 15627487 |
| D006202 | Hair Dyes | NAT2 protein polymorphism affects the susceptibility to Hair Dyes | affects response to substance | 12663508 |
| D006571 | Heterocyclic Compounds | NAT2 protein affects the metabolism of and results in increased activity of Heterocyclic Compounds | affects metabolic processing|increases activity | 12505289 |
| D006830 | Hydralazine | NAT2 protein affects the metabolism of Hydralazine | affects metabolic processing | 15627487 |
| D006830 | Hydralazine | NAT2 protein results in increased acetylation of Hydralazine | increases acetylation | 15627487 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased activity of NAT2 protein | decreases activity | 15644493 |
| D007460 | Iodoacetamide | Iodoacetamide results in decreased activity of and results in increased alkylation of NAT2 protein | decreases activity|increases alkylation | 15209520 |
| D007538 | Isoniazid | NAT2 gene polymorphism affects the susceptibility to Isoniazid | affects response to substance | 11379777 15618686 20485159 11915035 |
| D007538 | Isoniazid | NAT2 protein affects the metabolism of Isoniazid | affects metabolic processing | 15627487 |
| D007538 | Isoniazid | NAT2 protein polymorphism affects the metabolism of Isoniazid | affects metabolic processing | 15546075 15908628 |
| D007538 | Isoniazid | NAT2 protein polymorphism results in increased acetylation of Isoniazid | increases acetylation | 17973219 |
| D007538 | Isoniazid | NAT2 protein results in increased acetylation of Isoniazid | increases acetylation | 11379777 15627487 15565348 |
| D007538 | Isoniazid | NAT2 protein results in increased metabolism of Isoniazid | increases metabolic processing | 17509624 16847467 16531626 |
| D007538 | Isoniazid | NAT2 protein affects the metabolism of Isoniazid | affects metabolic processing | 15855489 |
| D007538 | Isoniazid | NAT2 protein polymorphism affects the susceptibility to Isoniazid | affects response to substance | 15855489 |
| D007538 | Isoniazid | NAT2 protein results in increased metabolism of Isoniazid | increases metabolic processing | 17950035 |
| D003915 | Dextromethorphan | NAT2 protein affects the metabolism of Dextromethorphan | affects metabolic processing | 15199075 |
| D008727 | Methotrexate | Methotrexate results in decreased activity of NAT2 protein | decreases activity | 16003948 |
| D008727 | Methotrexate | Methotrexate results in decreased activity of NAT2 protein modified form | decreases activity | 16003948 |
| C016272 | N-bromoacetamide | N-bromoacetamide results in decreased activity of and results in increased alkylation of NAT2 protein | decreases activity|increases alkylation | 15209520 |
| C001365 | N-hydroxy-4-acetylaminobiphenyl | N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein | decreases activity | 15720122 |
| C014593 | N-hydroxy-4-aminobiphenyl | NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl | increases metabolic processing | 16857729 |
| C007350 | nitrofen | NAT2 protein results in increased activity of nitrofen | increases activity | 14754874 |
| D030421 | Peroxynitrous Acid | Peroxynitrous Acid results in decreased activity of NAT2 protein | decreases activity | 15644493 |
| C030299 | phenylhydrazine | NAT2 protein results in increased acetylation of phenylhydrazine | increases acetylation | 15627487 |
| C095911 | polycyclic aromatic hydrocarbons-DNA adduct | NAT2 protein polymorphism results in increased abundance of polycyclic aromatic hydrocarbons-DNA adduct | increases abundance | 11967624 |
| D011084 | Polycyclic Hydrocarbons, Aromatic | NAT2 protein results in increased acetylation of Polycyclic Hydrocarbons, Aromatic | increases acetylation | 15122594 |
| D011342 | Procainamide | NAT2 protein affects the acetylation of Procainamide | affects acetylation | 15930747 |
| D011342 | Procainamide | NAT2 protein results in increased acetylation of Procainamide | increases acetylation | 16003948 |
| C035988 | procymidone | procymidone results in increased expression of NAT2 mRNA | increases expression | 15686871 |
| C076731 | simendan | NAT2 protein polymorphism results in increased acetylation of and results in increased activity of simendan | increases acetylation|increases activity | 15489122 |
| C076731 | simendan | NAT2 protein results in increased acetylation of and results in increased activity of simendan | increases acetylation|increases activity | 15489122 |
| D013411 | Sulfadiazine | NAT2 protein results in increased acetylation of Sulfadiazine | increases acetylation | 15843491 |
| D013418 | Sulfamethazine | NAT2 protein results in increased acetylation of Sulfamethazine | increases acetylation | 15627487 15880531 |
| D013420 | Sulfamethoxazole | NAT2 protein results in increased metabolism of Sulfamethoxazole | increases metabolic processing | 16847467 |
| D012460 | Sulfasalazine | NAT2 protein affects the metabolism of Sulfasalazine | affects metabolic processing | 15032315 |
| D012460 | Sulfasalazine | NAT2 protein polymorphism affects the metabolism of Sulfasalazine | affects metabolic processing | 15032315 |
| D013449 | Sulfonamides | NAT2 protein affects the metabolism of Sulfonamides | affects metabolic processing | 15627487 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of NAT2 mRNA | increases expression | 19684285 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of NAT2 mRNA | increases expression | 18434241 19933214 |
| D014051 | Toluene 2,4-Diisocyanate | NAT2 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate | increases response to substance | 11927838 |
| C025643 | vinclozolin | vinclozolin results in increased expression of NAT2 mRNA | increases expression | 15686871 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Carbamazepine | 10.37 | 8986270 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Methotrexate | 10.37 | 12039119 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 10.37 | 15322242 14514962 11752688 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 2.85 | 18287403 | |
| MESH:D058186 | Acute Kidney Injury | Folic Acid | 3.69 | 17003819 16316344 16595132 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 1.89 | 11473722 | |
| MESH:D000236 | Adenoma | 2-Acetylaminofluorene | 12.26 | 10737359 | |
| MESH:D000236 | Adenoma | 4,4'-diaminodiphenylmethane | 12.26 | 3712494 | |
| MESH:D000236 | Adenoma | Diethylnitrosamine | 12.26 | 10737359 6695378 | |
| MESH:D000236 | Adenoma | Folic Acid | 12.26 | 16963246 | |
| MESH:D002759 | Adenoma, Bile Duct | 2-Acetylaminofluorene | 5.28 | 6705139 | |
| MESH:D018248 | Adenoma, Liver Cell | 2-aminofluorene | 13.51 | 19052882 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 13.51 | 17620307 18056438 19061943 16434500 19052882 17162532 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 13.51 | 16835633 | |
| MESH:D000309 | Adrenal Insufficiency | Dehydroepiandrosterone | 5.07 | 17302879 | |
| MESH:D000380 | Agranulocytosis | Dapsone | 5.89 | 15999287 | |
| OMIM:607154 | ALLERGIC RHINITIS | 4,4'-diphenylmethane diisocyanate | 5.29 | 7973495 | |
| MESH:D000544 | Alzheimer Disease | Folic Acid | 2.86 | 17116317 | |
| MESH:D000740 | Anemia | phenylhydrazine | 7.09 | 2444515 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 7.09 | 11748828 | |
| MESH:D000741 | Anemia, Aplastic | Benzene | 3.80 | 14761424 11369114 17661222 | |
| MESH:D000743 | Anemia, Hemolytic | phenylhydrazine | 4.74 | 17698508 17084956 17082564 | |
| MESH:D000799 | Angioedema | Acetaminophen | 3.12 | 10982225 | |
| MESH:D001008 | Anxiety Disorders | vinclozolin | 3.06 | 19015723 | |
| MESH:D001172 | Arthritis, Rheumatoid | Methotrexate | 4.80 | 17286800 | |
| MESH:D001172 | Arthritis, Rheumatoid | Sulfasalazine | 4.80 | 9133974 | |
| MESH:D053627 | Asthenozoospermia | Sulfasalazine | 5.56 | 10689203 | |
| MESH:D001249 | Asthma | 1,6-hexamethylene diisocyanate | 6.94 | 10934080 | |
| MESH:D001249 | Asthma | 4,4'-diphenylmethane diisocyanate | 6.94 | 8156442 10797510 6091945 11077012 15891530 10934080 | |
| MESH:D001249 | Asthma | Toluene 2,4-Diisocyanate | 6.94 | 19187332 12762349 10934080 10797510 15590891 11742282 11467998 15855793 3040596 16792590 11077013 20032816 17015710 6091946 18394133 6091945 15590890 8156442 170078 16210060 12585506 12684321 7684630 | |
| MESH:D050197 | Atherosclerosis | Asbestos | 3.77 | 18795166 | |
| MESH:D001289 | Attention Deficit Disorder with Hyperactivity | Dextromethorphan | 4.83 | 17175572 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 2.18 | 18445737 | |
| MESH:D001321 | Autistic Disorder | Folic Acid | 2.18 | 21388746 | |
| MESH:D001528 | Behcet Syndrome | Sulfasalazine | 5.55 | 15870978 | |
| MESH:D001660 | Biliary Tract Diseases | 4,4'-diaminodiphenylmethane | 4.29 | 11289319 1440618 | |
| MESH:D001714 | Bipolar Disorder | Carbamazepine | 3.72 | 17594078 20046352 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 2.40 | 12125929 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 3.06 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 2.27 | 15746008 | |
| MESH:D001855 | Bone Marrow Diseases | Benzene | 4.50 | 16183116 | |
| MESH:D001943 | Breast Neoplasms | 4-biphenylamine | 4.74 | 17671175 | |
| MESH:D001943 | Breast Neoplasms | Benzene | 4.74 | 11921183 17162533 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 4.74 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 4.74 | 12948864 14630087 17289903 18497071 17261762 19861407 16675129 17018787 | |
| MESH:D001943 | Breast Neoplasms | Folic Acid | 4.74 | 16777985 | |
| MESH:D001943 | Breast Neoplasms | Methotrexate | 4.74 | 16978400 | |
| MESH:D001943 | Breast Neoplasms | Sulfasalazine | 4.74 | 17356269 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 4.74 | 20435547 | |
| MESH:D001943 | Breast Neoplasms | Toluene 2,4-Diisocyanate | 4.74 | 11921183 | |
| MESH:D016535 | Bronchial Hyperreactivity | 4,4'-diphenylmethane diisocyanate | 7.65 | 8156442 | |
| MESH:D016535 | Bronchial Hyperreactivity | Toluene 2,4-Diisocyanate | 7.65 | 15590891 12507178 8156442 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 3.75 | 16111702 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 2.22 | 16835633 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 2-Acetylaminofluorene | 9.16 | 10737359 17761372 6705139 3084413 3581430 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 2-aminofluorene | 9.16 | 19052882 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 4,4'-diaminodiphenylmethane | 9.16 | 7296757 3581430 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 9.16 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 9.16 | 18210153 19335982 16288022 18494052 16502159 20084675 19539802 19383236 10672840 16878318 18393292 11831363 17761372 20101231 16935385 18691550 20007298 17428255 19171122 19519916 18506893 19418558 17978847 18978308 17173139 18971187 19208518 20512989 19701751 19822196 17138121 16779866 16569478 10737359 20214788 16540662 3084413 16807293 19919837 18056438 19052882 20514400 20524982 16698587 16328049 16830150 17055752 20935162 20727157 18665156 20432363 16681979 19107877 18788625 3581430 19394651 18785209 21159647 17162532 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 9.16 | 16924424 | |
| MESH:D002292 | Carcinoma, Renal Cell | 4,4'-diaminodiphenylmethane | 2.29 | 7296757 | |
| MESH:D002294 | Carcinoma, Squamous Cell | erythritol anhydride | 4.21 | 10925838 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 1.93 | 18850075 18670907 16120746 | |
| MESH:D002318 | Cardiovascular Diseases | Folic Acid | 6.02 | 16755160 | |
| MESH:D002318 | Cardiovascular Diseases | Hydrogen Peroxide | 6.02 | 16936243 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.12 | 10977129 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4,4'-diaminodiphenylmethane | 15.60 | 7505956 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4-biphenylamine | 15.60 | 15746073 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 15.60 | 12371664 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 15.60 | 17174075 21159647 2727394 7505956 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 15.60 | 18566989 | |
| MESH:D002653 | Child Behavior Disorders | Dextromethorphan | 6.50 | 17175572 | |
| MESH:D018281 | Cholangiocarcinoma | 2-aminofluorene | 12.78 | 19052882 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 12.78 | 19052882 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 12.78 | 16835633 | |
| MESH:D002779 | Cholestasis | 4,4'-diaminodiphenylmethane | 6.04 | 9022650 19486331 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 6.04 | 19486331 | |
| MESH:D043171 | Chromosomal Instability | 4-biphenylamine | 6.28 | 17671175 | |
| MESH:D002971 | Cleft Lip | Folic Acid | 3.56 | 21254359 | |
| MESH:D002972 | Cleft Palate | Folic Acid | 4.89 | 8946559 21254359 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 4.89 | 15668235 8697196 16354765 15340226 12621046 | |
| MESH:D003093 | Colitis, Ulcerative | Mesalamine | 6.38 | 17339853 | |
| MESH:D003093 | Colitis, Ulcerative | Sulfasalazine | 6.38 | 15955209 17339853 | |
| MESH:D015179 | Colorectal Neoplasms | 4-biphenylamine | 3.23 | 17671175 | |
| MESH:D015179 | Colorectal Neoplasms | Folic Acid | 3.23 | 17087956 17116713 17245555 16985020 16963246 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 2.45 | 17141729 14669216 | |
| MESH:D003233 | Conjunctivitis, Allergic | 4,4'-diphenylmethane diisocyanate | 5.70 | 7973495 | |
| MESH:D003324 | Coronary Artery Disease | marker/mechanism | 21572414 | ||
| MESH:D003371 | Cough | Dextromethorphan | 5.41 | 17323712 | |
| MESH:D019465 | Craniofacial Abnormalities | Benzene | 6.08 | 15643154 | |
| MESH:D019465 | Craniofacial Abnormalities | Carbamazepine | 6.08 | 9014606 | |
| MESH:D019465 | Craniofacial Abnormalities | Methotrexate | 6.08 | 9562676 12039119 | |
| MESH:D019465 | Craniofacial Abnormalities | nitrofen | 6.08 | 11405365 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 6.08 | 10048152 20055451 15322242 | |
| MESH:D003456 | Cryptorchidism | vinclozolin | 3.66 | 14966744 | |
| MESH:D003550 | Cystic Fibrosis | Methotrexate | 3.62 | 19747007 | |
| MESH:D003872 | Dermatitis | Benzene | 4.07 | 15902427 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 1,6-hexamethylene diisocyanate | 14.61 | 18759878 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4,4'-diaminodiphenylmethane | 14.61 | 14531868 8970840 11906362 18759878 2524372 8156756 11298694 12868966 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4,4'-diphenylmethane diisocyanate | 14.61 | 12868966 18759878 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4-phenylenediamine | 14.61 | 19470301 11298694 16533241 16823706 11906362 18759875 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Toluene 2,4-Diisocyanate | 14.61 | 15491423 18759878 12956900 | |
| MESH:D003877 | Dermatitis, Contact | 4,4'-diaminodiphenylmethane | 12.10 | 2952479 3621924 | |
| MESH:D003877 | Dermatitis, Contact | 4-phenylenediamine | 12.10 | 11531941 | |
| MESH:D003877 | Dermatitis, Contact | Toluene 2,4-Diisocyanate | 12.10 | 17010967 | |
| MESH:D003882 | Dermatomyositis | Methotrexate | 4.44 | 20191521 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Dehydroepiandrosterone | 3.43 | 16616286 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 5.77 | 20387270 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Folic Acid | 5.77 | 16886840 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 5.77 | 17107852 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 2.80 | 19279558 | |
| OMIM:607208 | DRAVET SYNDROME | Carbamazepine | 4.75 | 11748493 | |
| MESH:D004342 | Drug Hypersensitivity | marker/mechanism | 21572414 20485159 | ||
| MESH:D004342 | Drug Hypersensitivity | Carbamazepine | 3.93 | 16538176 20216337 15057820 16538175 | |
| MESH:D056486 | Drug-Induced Liver Injury | marker/mechanism | 11915035 16799928 17950035 | ||
| MESH:D056486 | Drug-Induced Liver Injury | 4,4'-diaminodiphenylmethane | 11.60 | 7440962 18692083 16192314 18289764 6482804 9328219 1440618 11289319 8291058 18648102 9653073 6679447 9022650 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 11.60 | 18713872 11743745 17562736 19739265 12594235 17906064 19420014 14986274 12958197 19416960 19370779 19085960 16485898 12540782 15619225 10915739 12392966 16081117 11529661 11739529 12153990 16781746 16393943 12705907 17522070 14725611 19164858 16177239 2444490 16227642 19923254 11834606 11421492 11287661 10663392 11461765 10774834 16109766 14550746 15968718 18071297 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbamazepine | 11.60 | 17465707 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 11.60 | 19107877 | |
| MESH:D056486 | Drug-Induced Liver Injury | Isoniazid | 11.60 | 14986274 16770646 17950035 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 11.60 | 20420201 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 3.37 | 19426721 | |
| MESH:D004362 | Drug Toxicity | Carbamazepine | 6.56 | 20216337 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 6.56 | 11462148 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 1.78 | 12711302 11000095 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 3.18 | 15322242 16714409 18230668 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Carbamazepine | 4.06 | 17654737 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 6.07 | 19148513 11473722 18566989 | |
| MESH:D016889 | Endometrial Neoplasms | Folic Acid | 6.07 | 17301261 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 2.40 | 9294722 10568697 | |
| MESH:D004802 | Eosinophilia | 4,4'-diphenylmethane diisocyanate | 7.66 | 8156442 | |
| MESH:D004802 | Eosinophilia | Toluene 2,4-Diisocyanate | 7.66 | 8156442 | |
| MESH:D004816 | Epidermal Necrolysis, Toxic | Carbamazepine | 4.57 | 16415921 18855540 16538176 19915237 20485159 | |
| MESH:D004831 | Epilepsies, Myoclonic | Carbamazepine | 4.52 | 17275665 | |
| MESH:D004828 | Epilepsies, Partial | Carbamazepine | 4.25 | 16628512 17116037 15008574 | |
| MESH:D004827 | Epilepsy | Carbamazepine | 3.58 | 18234410 19439326 7988514 9014606 19620853 821787 17178248 19700373 20417680 17465707 | |
| MESH:D017029 | Epilepsy, Complex Partial | Carbamazepine | 4.66 | 7750514 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Carbamazepine | 4.41 | 3659116 15276670 | |
| MESH:D004916 | Erythromelalgia | Carbamazepine | 5.01 | 19549232 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 4.39 | 16302075 | |
| MESH:D004938 | Esophageal Neoplasms | 4,4'-diaminodiphenylmethane | 1.89 | 3581430 | |
| MESH:D005076 | Exanthema | Carbamazepine | 4.75 | 20485159 | |
| MESH:D017889 | Exfoliation Syndrome | Folic Acid | 4.78 | 16504073 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 2.46 | 11564622 | |
| MESH:D005128 | Eye Diseases | Toluene 2,4-Diisocyanate | 5.03 | 18447907 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 5.60 | 19224547 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 5.60 | 20387270 21071580 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 2.76 | 11858732 | |
| MESH:D005334 | Fever | 4,4'-diphenylmethane diisocyanate | 5.01 | 7973495 | |
| MESH:D005350 | Fibroma | 4,4'-diaminodiphenylmethane | 4.29 | 6705139 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 6.19 | 12168785 12639820 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 6.19 | 20067830 | |
| MESH:D005756 | Gastritis | Acetaminophen | 15.13 | 16983495 | |
| MESH:D005756 | Gastritis | Folic Acid | 15.13 | 17171786 | |
| MESH:D005756 | Gastritis | Iodoacetamide | 15.13 | 15046732 | |
| MESH:D030342 | Genetic Diseases, Inborn | vinclozolin | 4.22 | 16973722 | |
| MESH:D005832 | Genital Diseases, Male | vinclozolin | 4.57 | 16417039 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 3.50 | 8708960 | |
| MESH:D005901 | Glaucoma | Folic Acid | 4.41 | 16504073 | |
| MESH:D006042 | Goiter | 4,4'-diaminodiphenylmethane | 3.37 | 7505956 | |
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 3.87 | 10696789 | |
| MESH:D006086 | Graft vs Host Disease | Methotrexate | 4.45 | 16518429 | |
| MESH:D016460 | Granuloma Annulare | Dapsone | 6.70 | 15999287 | |
| MESH:D006330 | Heart Defects, Congenital | Folic Acid | 8.92 | 17286298 16524890 | |
| MESH:D006330 | Heart Defects, Congenital | nitrofen | 8.92 | 16080930 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 8.92 | 10048152 11294989 | |
| MESH:D006333 | Heart Failure | simendan | 5.67 | 19101796 | |
| MESH:D006390 | Hemangioendothelioma | 2-Acetylaminofluorene | 4.59 | 6705139 | |
| MESH:D006394 | Hemangiosarcoma | 2-Acetylaminofluorene | 8.09 | 6705139 | |
| MESH:D006394 | Hemangiosarcoma | 4-chloroaniline | 8.09 | 15200160 | |
| MESH:D006402 | Hematologic Diseases | Benzene | 3.99 | 16183116 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 3.71 | 15720958 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 2.69 | 11000095 | |
| MESH:D006486 | Hemosiderosis | Dapsone | 5.90 | 17053738 | |
| MESH:D006505 | Hepatitis | 4,4'-diaminodiphenylmethane | 7.49 | 6705139 | |
| MESH:D006505 | Hepatitis | Caffeine | 7.49 | 11394713 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 2.21 | 12621046 15340226 16120746 | |
| MESH:D006548 | Hernia, Diaphragmatic | nitrofen | 3.63 | 15136996 11051153 10898224 11588001 18958481 16473863 7760232 16863852 10370016 18280291 18280292 10541330 9698600 9575882 12407540 15707848 15756563 17270546 16292651 11685700 11057544 10359170 15185205 9476886 11329586 15764645 9473106 10646786 16490937 12746050 8863223 16080930 12194112 7576705 12759764 17618886 11409163 10370017 12505043 10898222 10693666 15793718 15088113 12547725 12904592 9859898 15578192 11076806 17245593 16720372 7520565 12021965 11584395 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 4.30 | 15709030 | |
| MESH:D006679 | HIV Seropositivity | Folic Acid | 4.78 | 17209195 | |
| MESH:D019584 | Hot Flashes | Estradiol | 3.03 | 17088409 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 3.32 | 15340226 16959395 8697196 16354765 18606429 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.13 | 16870215 | |
| MESH:D020138 | Hyperhomocysteinemia | Carbamazepine | 7.81 | 10459572 | |
| MESH:D020138 | Hyperhomocysteinemia | Folic Acid | 7.81 | 16865747 16395265 16397167 16433478 16755160 | |
| MESH:D006965 | Hyperplasia | 4,4'-diaminodiphenylmethane | 8.81 | 15034207 | |
| MESH:D006965 | Hyperplasia | Carbamazepine | 8.81 | 18773962 | |
| MESH:D006967 | Hypersensitivity | Toluene 2,4-Diisocyanate | 3.98 | 11019492 10880147 | |
| MESH:D006973 | Hypertension | Benzene | 6.65 | 17940673 | |
| MESH:D006973 | Hypertension | Cyclosporine | 6.65 | 10903974 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 6.65 | 18670907 18850075 | |
| MESH:D046110 | Hypertension, Pregnancy-Induced | Hydralazine | 3.93 | 16612254 | |
| MESH:D007248 | Infertility, Male | Sulfasalazine | 5.84 | 10689203 | |
| MESH:D007248 | Infertility, Male | vinclozolin | 5.84 | 16467254 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 3.53 | 18785209 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 3.53 | 12878042 12200463 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Sulfasalazine | 4.34 | 15339030 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 2.47 | 16627594 16393666 | |
| MESH:D007565 | Jaundice | 4,4'-diaminodiphenylmethane | 4.29 | 8074119 9022650 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 2.69 | 16580747 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 3.71 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 7.32 | 12587719 15629191 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 7.32 | 10903974 8314463 18776723 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 7.32 | 15618244 | |
| MESH:D007676 | Kidney Failure, Chronic | Hydrogen Peroxide | 3.63 | 16518626 | |
| MESH:D007680 | Kidney Neoplasms | 4,4'-diaminodiphenylmethane | 8.95 | 6582329 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 8.95 | 12371664 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 8.95 | 15610895 | |
| MESH:D007805 | Language Development Disorders | Methotrexate | 4.44 | 9562676 | |
| MESH:D007938 | Leukemia | Benzene | 2.99 | 17119257 18335105 14694614 15935818 | |
| MESH:D007951 | Leukemia, Myeloid | Benzene | 3.68 | 17506065 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Benzene | 2.55 | 19478238 | |
| MESH:D007984 | Leydig Cell Tumor | vinclozolin | 4.02 | 16417039 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 5.46 | 18522880 18407596 20032147 19638242 18665156 | |
| MESH:D008103 | Liver Cirrhosis | Methotrexate | 5.46 | 14986274 | |
| MESH:D008105 | Liver Cirrhosis, Biliary | 4,4'-diaminodiphenylmethane | 2.71 | 15034207 9327722 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 3.04 | 14659978 14716833 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Sulfasalazine | 3.04 | 15633128 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 3.04 | 12878042 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 9.89 | 19460945 16610002 19014921 11587558 19784758 12587719 12969438 16611625 | |
| MESH:D008107 | Liver Diseases | Dapsone | 9.89 | 17053738 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 9.89 | 17034775 | |
| MESH:D008107 | Liver Diseases | Folic Acid | 9.89 | 16877991 | |
| MESH:D008107 | Liver Diseases | Sulfonamides | 9.89 | 14986274 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 2.61 | 17185352 16871587 | |
| MESH:D008113 | Liver Neoplasms | 2-Acetylaminofluorene | 16.74 | 18001218 14678523 16273603 11376686 10737359 10672840 | |
| MESH:D008113 | Liver Neoplasms | 2-aminofluorene | 16.74 | 20452335 20492335 19499222 19850985 | |
| MESH:D008113 | Liver Neoplasms | 4-biphenylamine | 16.74 | 15761837 | |
| MESH:D008113 | Liver Neoplasms | 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole | 16.74 | 12970073 | |
| MESH:D008113 | Liver Neoplasms | Dehydroepiandrosterone | 16.74 | 18709148 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 16.74 | 21047994 21278145 19256749 12112319 19551842 20452335 21071580 18648771 18978307 16942905 9163691 19499222 19294768 20137499 19642983 15175105 20583210 19254457 2862719 19427195 19073162 19812893 19850985 18644402 15885732 19426721 20492335 18977376 20501860 20101389 20434301 18754104 19833225 12771043 19996281 19638242 20118626 19690152 10737359 19090486 21167192 20405173 2422723 19255062 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 16.74 | 16984957 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 2-Acetylaminofluorene | 20.85 | 6150874 534488 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 4,4'-diaminodiphenylmethane | 20.85 | 598648 3712494 6587162 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 4-biphenylamine | 20.85 | 11376689 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Benzene | 20.85 | 12562636 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Dehydroepiandrosterone | 20.85 | 8603461 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 20.85 | 16842330 19126423 18282651 18164116 19004024 18079962 19009564 18775883 9362446 18544905 17942915 18253720 18093689 16267830 19519916 17174075 2563599 17854601 18308698 19539802 21159647 3124819 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 20.85 | 12151625 | |
| MESH:D008171 | Lung Diseases | nitrofen | 3.90 | 9614859 16863852 17245593 9859898 | |
| MESH:D017563 | Lung Diseases, Interstitial | Benzene | 9.26 | 14698565 | |
| MESH:D017563 | Lung Diseases, Interstitial | Methotrexate | 9.26 | 18516814 | |
| MESH:D008175 | Lung Neoplasms | 2-Acetylaminofluorene | 8.63 | 11376686 | |
| MESH:D008175 | Lung Neoplasms | 4-biphenylamine | 8.63 | 17671175 | |
| MESH:D008175 | Lung Neoplasms | Asbestos | 8.63 | 12111688 | |
| MESH:D008175 | Lung Neoplasms | Benzene | 8.63 | 12562636 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 8.63 | 20970405 21163286 6695378 20512841 | |
| MESH:D008175 | Lung Neoplasms | Polycyclic Hydrocarbons, Aromatic | 8.63 | 10814675 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 8.63 | 19555203 11884234 | |
| MESH:D008180 | Lupus Erythematosus, Systemic | Carbamazepine | 5.03 | 16628512 | |
| MESH:D008180 | Lupus Erythematosus, Systemic | Folic Acid | 5.03 | 17718048 | |
| MESH:D008223 | Lymphoma | Benzene | 6.24 | 17584886 17119257 | |
| MESH:D008223 | Lymphoma | Methotrexate | 6.24 | 17352296 | |
| MESH:D015674 | Mammary Neoplasms, Animal | Benzene | 3.74 | 12562636 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Benzene | 7.34 | 11921183 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Dehydroepiandrosterone | 7.34 | 16457693 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 7.34 | 16891317 11807958 17203775 11408345 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 3.76 | 19453300 | |
| MESH:D019767 | Maxillofacial Abnormalities | Folic Acid | 4.98 | 16832597 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 2.87 | 19513568 | |
| MESH:D008607 | Mental Retardation | Carbamazepine | 3.43 | 9014606 | |
| MESH:D008654 | Mesothelioma | Asbestos | 3.75 | 16319530 18709470 16564556 16919927 18310086 | |
| MESH:D008661 | Metabolism, Inborn Errors | marker/mechanism | |||
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 4.06 | 16801185 | |
| MESH:D008708 | Methemoglobinemia | 3,4-dichloroaniline | 8.27 | 4714336 | |
| MESH:D008708 | Methemoglobinemia | 4-biphenylamine | 8.27 | 12030840 | |
| MESH:D052016 | Mucositis | Methotrexate | 4.57 | 17488658 | |
| MESH:D009101 | Multiple Myeloma | Benzene | 3.14 | 17119195 | |
| MESH:D009164 | Mycobacterium Infections | Isoniazid | 5.25 | 18474467 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 2.44 | 12213967 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 2.72 | 16810080 | |
| MESH:D009224 | Myotonia Congenita | Carbamazepine | 4.75 | 20399394 | |
| MESH:D009362 | Neoplasm Metastasis | 4,4'-diaminodiphenylmethane | 4.54 | 3581430 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 4.54 | 3581430 9029167 | |
| MESH:D009374 | Neoplasms, Experimental | erythritol anhydride | 7.96 | 10925838 | |
| MESH:D009374 | Neoplasms, Experimental | Toluene 2,4-Diisocyanate | 7.96 | 1670384 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 3.03 | 17289903 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 3.71 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 2.67 | 19348381 18481113 | |
| MESH:D009421 | Nervous System Malformations | Carbamazepine | 12.57 | 16990009 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 12.57 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 12.57 | 14600291 | |
| MESH:D009436 | Neural Tube Defects | 4,4'-diaminodiphenylmethane | 9.40 | 6679447 | |
| MESH:D009436 | Neural Tube Defects | Benzene | 9.40 | 15643154 | |
| MESH:D009436 | Neural Tube Defects | Folic Acid | 9.40 | 17438019 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 6.21 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 6.21 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 4.39 | 20387270 | |
| MESH:D009503 | Neutropenia | Folic Acid | 3.85 | 16322990 | |
| MESH:D009784 | Occupational Diseases | 4,4'-diaminodiphenylmethane | 16.64 | 4026338 6482804 | |
| MESH:D009784 | Occupational Diseases | 4,4'-diphenylmethane diisocyanate | 16.64 | 8156442 6091945 | |
| MESH:D009784 | Occupational Diseases | Benzene | 16.64 | 17178637 17119257 16737584 15612468 15913788 15576619 15727169 17479406 15935809 | |
| MESH:D009784 | Occupational Diseases | Toluene 2,4-Diisocyanate | 16.64 | 6091945 3040596 18394133 11077013 12585506 6091946 8156442 | |
| MESH:D009902 | Optic Neuritis | 4,4'-diaminodiphenylmethane | 4.29 | 3988306 | |
| MESH:D010018 | Osteomalacia | Carbamazepine | 4.75 | 17016548 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Dehydroepiandrosterone | 4.37 | 16397352 | |
| MESH:D010051 | Ovarian Neoplasms | Benzene | 4.08 | 12562636 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 4.08 | 19401270 | |
| MESH:D010146 | Pain | Acetaminophen | 5.08 | 16870215 | |
| MESH:D010146 | Pain | Carbamazepine | 5.08 | 15215642 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.12 | 16540662 | |
| MESH:D010212 | Papilloma | 4,4'-diaminodiphenylmethane | 7.02 | 7296757 | |
| MESH:D010212 | Papilloma | Hydrogen Peroxide | 7.02 | 12065085 | |
| MESH:D010267 | Parapsoriasis | Carbamazepine | 5.00 | 16538176 | |
| OMIM:167400 | PAROXYSMAL EXTREME PAIN DISORDER | Carbamazepine | 5.21 | 17145499 17679678 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 3.52 | 12520081 | |
| MESH:D010787 | Photosensitivity Disorders | 4,4'-diaminodiphenylmethane | 3.74 | 6228378 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 2.88 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 6.91 | 12371664 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 6.91 | 2563599 | |
| MESH:D011248 | Pregnancy Complications | Carbamazepine | 4.46 | 9014606 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Carbamazepine | 12.28 | 9014606 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 12.28 | 11118676 11399792 11896295 11222880 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | vinclozolin | 12.28 | 18042343 18220299 19015723 | |
| MESH:D011469 | Prostatic Diseases | vinclozolin | 4.22 | 18220299 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 3.24 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | marker/mechanism | 12622714 15717312 16083506 | ||
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 3.41 | 16740699 | |
| MESH:D011472 | Prostatitis | vinclozolin | 4.22 | 18629315 | |
| MESH:D019310 | Pseudolymphoma | Carbamazepine | 4.87 | 12752131 9591791 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 4.86 | 16882103 | |
| MESH:D011565 | Psoriasis | Methotrexate | 4.86 | 17410198 | |
| MESH:D011657 | Pulmonary Eosinophilia | Toluene 2,4-Diisocyanate | 4.90 | 14606601 | |
| MESH:D051437 | Renal Insufficiency | Folic Acid | 8.39 | 15728788 | |
| MESH:D051437 | Renal Insufficiency | Methotrexate | 8.39 | 17352296 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | 4,4'-diphenylmethane diisocyanate | 4.97 | 7973495 | |
| MESH:D012130 | Respiratory Hypersensitivity | 4,4'-diphenylmethane diisocyanate | 7.53 | 16940033 | |
| MESH:D012130 | Respiratory Hypersensitivity | Toluene 2,4-Diisocyanate | 7.53 | 7692837 20219652 16940033 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 3.16 | 18990726 | |
| MESH:D012140 | Respiratory Tract Diseases | Toluene 2,4-Diisocyanate | 4.40 | 18447907 | |
| MESH:D012162 | Retinal Degeneration | 4,4'-diaminodiphenylmethane | 2.82 | 3692021 | |
| MESH:D012220 | Rhinitis | Toluene 2,4-Diisocyanate | 3.96 | 19050374 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Toluene 2,4-Diisocyanate | 4.55 | 15015336 12617775 | |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | Toluene 2,4-Diisocyanate | 4.79 | 19075512 | |
| MESH:D012559 | Schizophrenia | Folic Acid | 2.78 | 16641680 | |
| MESH:D012640 | Seizures | Carbamazepine | 7.58 | 9844417 9046859 16938433 19414003 15946322 16876388 16180713 | |
| MESH:D012640 | Seizures | Isoniazid | 7.58 | 16107249 | |
| MESH:D012640 | Seizures | Sulfonamides | 7.58 | 20420384 | |
| MESH:D012871 | Skin Diseases | Folic Acid | 3.02 | 18709164 | |
| MESH:D012878 | Skin Neoplasms | Hydrogen Peroxide | 4.43 | 12065085 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 4.43 | 16192470 | |
| MESH:D012893 | Sleep Disorders | Caffeine | 8.98 | 19395429 | |
| MESH:D012893 | Sleep Disorders | Carbamazepine | 8.98 | 19414003 | |
| MESH:D007319 | Sleep Initiation and Maintenance Disorders | Caffeine | 4.38 | 17225163 | |
| MESH:D012912 | Sneezing | Toluene 2,4-Diisocyanate | 4.79 | 19050374 19075512 | |
| MESH:D013118 | Spinal Cord Diseases | Folic Acid | 4.78 | 16361298 | |
| MESH:D013158 | Splenic Diseases | aniline | 5.69 | 15694462 | |
| MESH:D013262 | Stevens-Johnson Syndrome | Carbamazepine | 4.52 | 15057820 19915237 20485159 16538176 16415921 19694795 18855540 | |
| MESH:D013274 | Stomach Neoplasms | Benzene | 3.01 | 12562636 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 3.01 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | Folic Acid | 3.01 | 17171786 | |
| MESH:D020521 | Stroke | Folic Acid | 3.75 | 16517955 | |
| MESH:D013576 | Syndactyly | Methotrexate | 4.35 | 9562676 | |
| MESH:D013953 | Thymus Neoplasms | Benzene | 4.24 | 10850423 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 3.18 | 12697716 | |
| MESH:D013964 | Thyroid Neoplasms | 4,4'-diaminodiphenylmethane | 5.26 | 3712494 7505956 1399818 6582329 6587162 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 5.26 | 7505956 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 3.96 | 19048282 | |
| MESH:D014376 | Tuberculosis | Isoniazid | 4.70 | 16770646 15236969 17720495 15673755 17950035 18397238 | |
| MESH:D001749 | Urinary Bladder Neoplasms | marker/mechanism | 20972438 15717312 18505952 | ||
| MESH:D001749 | Urinary Bladder Neoplasms | 2-Acetylaminofluorene | 12.24 | 15289314 1399818 15867355 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 2-Naphthylamine | 12.24 | 11144890 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 4,4'-diaminodiphenylmethane | 12.24 | 8074119 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 4-biphenylamine | 12.24 | 6654951 11144890 12376482 17671175 | |
| MESH:D001749 | Urinary Bladder Neoplasms | benzidine | 12.24 | 12500666 16003747 11144890 | |
| MESH:D014581 | Urticaria | Acetaminophen | 2.33 | 10982225 | |
| MESH:D014594 | Uterine Neoplasms | Benzene | 3.66 | 12562636 | |
| MESH:D014605 | Uveitis | Cyclosporine | 3.26 | 1336536 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 3.87 | 12125929 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 3.52 | 15886252 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 3.71 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:13433 | Biological oxidations |
| KEGG:00232 | Caffeine metabolism |
| KEGG:00983 | Drug metabolism - other enzymes |
| KEGG:01100 | Metabolic pathways |
| Releated gene ID | Related gene Name |
|---|---|
| PA182 | GSTM1 |
| PA29024 | GSTM3 |
| PA18 | NAT2 |
| Releated disease ID | Related disease Name |
|---|---|
| PA445425 | Prostatic Neoplasms |
| PA165108527 | Drug-induced chronic hepatitis |
| PA443450 | Asthma |
| PA443512 | Urinary Bladder Neoplasms |
| PA446108 | Colorectal Neoplasms |
| PA443434 | Arthritis, Rheumatoid |
| PA446863 | Hepatitis C, Chronic |
| PA443645 | Cataract |
| PA443829 | Cystic Fibrosis |
| PA444355 | Hearing Disorders |
| PA444065 | Epilepsy |
| PA445941 | Tuberculosis |
| PA443937 | Drug Toxicity |
| PA444801 | Liver Diseases |
| PA443224 | Abnormalities, Drug-Induced |
| PA164925725 | Toxic liver disease |
| Releated drug ID | Related drug Name |
|---|---|
| PA449383 | docetaxel |
| PA451644 | thalidomide |
| PA164712445 | Antihypertensives |
| PA449211 | dapsone |
| PA449050 | clonazepam |
| PA450112 | isoniazid |
| PA451545 | sulfanilamide |
| PA448497 | aspirin |
| PA165820585 | 1,7-dimethylxanthine |
| PA451647 | theophylline |
| PA452614 | furafylline |
| PA448073 | ethanol |
| PA451646 | theobromine |
| PA165109660 | genistein |
| PA448710 | caffeine |
| PA451999 | interferons |
| PA451241 | ribavirin |
| PA449273 | dextromethorphan |
| PA451542 | sulfamethazine |
| PA450428 | methotrexate |
| PA451547 | sulfasalazine |
| PA144997862 | retigabine |
| PA450112 | isoniazid |
| PA451544 | sulfamethoxazole |
| PA452604 | xenobiotics |
| PA451108 | procainamide |
| PA449894 | hydralazine |
| PA164712708 | Drugs For Treatment Of Tuberculosis |
| No data |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00250 | substrate | Dapsone | Anti-Infective Agents;Anti-Infectives;Anti-inflammatory Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents;Antimycobacterials |
| DB00951 | substrate | Rifater | Antitubercular Agents;Fatty Acid Synthesis Inhibitors |
| DB01015 | substrate | Sulfamethoxazole and Trimethoprim Tablets | Anti-Infective Agents;Anti-Infectives;Sulfonamides |
| No data |
| No data |