AutismKB 2.0

Annotation Detail for ADA


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Basic Information Top
Gene Symbol:ADA ( - )
Gene Full Name: adenosine deaminase
Band: 20q13.12
Quick LinksEntrez ID:100; OMIM: 608958; Uniprot ID:ADA_HUMAN; ENSEMBL ID: ENSG00000196839; HGNC ID: 186
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
SALVADEHYPOX-PWYsalvage pathways of adenine, hypoxanthine, and their nucleosides
PWY-6353purine nucleotides degradation II (aerobic)
Pathway IDPathway Name
hsa00230Purine metabolism
hsa05340Primary immunodeficiency
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
Pathway IDPathway Name
200130C-MYB transcription factor network
Pathway IDPathway Name
P02723Adenine and hypoxanthine salvage pathway
Pathway IDPathway Name
500227Purine salvage
Related Diseases/Disorders Top
Desease IDDesease Name
H00092T-B- Severe combined immunodeficiencies
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1772Peptic ulcer
1773Combined immunodeficiency
1816Hydatidiform mole
1902Kidney failure
1904Diabetes mellitus
1918Atherosclerosis
2001Mental retardation
2091Hypertension
2044Pre-Eclampsia
2074Asthma
2124Autistic disorder
2146Lupus erythematosus
2203Nephrosis
Desease Name
atherosclerosis, coronary
CARDIOVASCULAR
PSYCH
intrauterine growth
hepatitis C
REPRODUCTION
Autism
INFECTION
No data
Desease Name
Severe combined immunodeficiency due to ADA deficiency
Adenosine deaminase deficiency, partial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025223 1,4-dioxane 1,4-dioxane affects the activity of ADA proteinaffects activity 11583161
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADA mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADA mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADA mRNAincreases expression 16788091
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of ADA mRNAdecreases expression 19901195
D000082 Acetaminophen Acetaminophen affects the expression of ADA mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in increased expression of ADA mRNAincreases expression 16982809
C018824 ammonium acetate ammonium acetate results in increased activity of ADA proteinincreases activity 19900420
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADA mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ADA mRNAincreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased activity of ADA proteinincreases activity 19900420
D000431 Ethanol Ethanol affects the activity of ADA proteinaffects activity 11583161
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADA mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADA mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADA mRNAincreases expression 17557909
D000432 Methanol Methanol affects the activity of ADA proteinaffects activity 11583161
C030110 oxaliplatin oxaliplatin results in decreased expression of ADA mRNAdecreases expression 17762391
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ADA mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ADA mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of ADA mRNAdecreases expression 17426115
C089730 rosiglitazone rosiglitazone results in increased expression of ADA mRNAincreases expression 16982809
D013395 Sucrose Sucrose affects the activity of ADA proteinaffects activity 11583161
D013629 Tamoxifen Tamoxifen affects the expression of ADA mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADA mRNAdecreases expression 19901195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADA mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADA mRNAincreases expression 19933214
D002762 Cholecalciferol Cholecalciferol results in decreased expression of ADA mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.5018926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.506195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.5015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.0318287403
MESH:D000138 Acidosis Ethanol 10.0311192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0720127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.586695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.5317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5316835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1915451039 15451040
MESH:D000544 Alzheimer Disease rosiglitazone 2.8219621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D000853 Anophthalmos Ethanol 4.6915513904
MESH:D001008 Anxiety Disorders Ethanol 3.9011141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D001321 Autistic Disorder marker/mechanism 11354825
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9016142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.8019115204 16202921 18629630 16818667 18351453 20005174 15565566 16273361 15668708 19244106 20544844 19103187 19189210 19059307 11161223 19289846 20135344 18855134 19155303 18984771 17049068 18425577 20065188 17242785 17261762 19142967 19487384 19011961 19200415 18815881 18821012 19066611 18997820 19189212 16873071 19084267 20859285 20390343 17893378 19288272 17440819 21138602 21152245 19221464 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002056 Burns Ethanol 4.5216374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6515700767 3786805 16011737 15673190 18705752 15721981 16124888 16227642 16097048 16050911 10355542 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.123084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.1218788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.1215763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.1220935162 17173139 6705139 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.1216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0120419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Ethanol 6.6119332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Am 580 7.4317460283
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4216919318 17681005 16105132 15861022 11677210 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 7.4219176532
MESH:D002971 Cleft Lip Ethanol 3.5215513904
MESH:D002972 Cleft Palate Ethanol 9.8315513904
MESH:D002972 Cleft Palate Methanol 9.838946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.8316354765 15340226 8697196 12621046 15668235
MESH:D003092 Colitis Am 580 4.8317035595
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1516004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9417594712 18509181 18448328 17695437 17401013 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 4.0415451039 15451040 11198716 19302082 10194807 11873399 15513904
MESH:D019465 Craniofacial Abnormalities Methanol 4.0415108243
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.0410048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1917446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.3912642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5916227642 12594235 11834606 18713872 19416960 14550746 18071297 11287661 11461765 11739529 16109766 19164858 16177239 12153990 14986274 19739265 12958197 12540782 12705907 11743745 16081117 17906064 19085960 11529661 16781746 10663392 14725611 19420014 19923254 10915739 12392966 16485898 2444490 16393943 15619225 10774834 11421492 15968718 17562736 17522070 19370779
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.597120509 10092053 11566570 2869522 15998439 6884620 15027814 10915739 17522070 7440962 3786805 21278145 4309450 16177239 9327722 19085960 16227642 15968718 19336974 3732212 6623471 7179309
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.5911566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D004421 Dystonia Phenobarbital 3.881851702
MESH:D004487 Edema pirinixic acid 10.7812083418
MESH:D004487 Edema rosiglitazone 10.7812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.5212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.5219031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.5319148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.5317893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.983659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.743922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.436401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.127750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.893659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.4916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.1661145 17595544 19224547 16239168 16045604 12795759 12631006 15959796
MESH:D005234 Fatty Liver Ethanol 29.1616409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.1615345470
MESH:D005234 Fatty Liver pirinixic acid 29.1619236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 29.1619196556
MESH:D005234 Fatty Liver Tamoxifen 29.1619224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5417920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1616709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1715513904 16946407 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1620067830
MESH:D005756 Gastritis Acetaminophen 10.7016983495
MESH:D005756 Gastritis Ethanol 10.7015046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 13.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 13.6319772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6316120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 17.8916870215
MESH:D006930 Hyperalgesia Ethanol 17.8918783367
MESH:D006930 Hyperalgesia oxaliplatin 17.8917418472
MESH:D006930 Hyperalgesia rosiglitazone 17.8912083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4017937319
MESH:D007249 Inflammation rosiglitazone 7.9712083418
MESH:D007249 Inflammation Tamoxifen 7.9719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.2216306350
MESH:D007333 Insulin Resistance rosiglitazone 7.2216306350
MESH:D007569 Jaw Abnormalities Ethanol 9.7215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1215629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.0316705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.0318625569
MESH:D007859 Learning Disorders Ethanol 4.0815451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7217676605
MESH:D008064 Lipidoses Tamoxifen 3.0617567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6816943688 17157831 17174718 11903743 21278145 16221502 11408273 17334410 16239168
MESH:D008103 Liver Cirrhosis Ethanol 10.6815289165
MESH:D008103 Liver Cirrhosis Phenobarbital 10.6821047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9718295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.5318395914 18166357 18472094 17976157 17708605 18395095 15818738 18418968 15673190 12609069 18472332 12667390 15996030 17525996 12898905 12445421 18376398 20821823 12586293 17640975 12958196 18420326 14748882 11481614 17714472 15876570 15730626 16027843 17631135 18156304 16136751 18429990 12546737 17766677 18339082 15959796 12632514 14716833 18187930 18263696 16248980 18481824 12632512 18705752 17805973 15057751 18210741 17900296 17557913 16097048 15338365 17721639 15362042 10355542 16192424 16033810 17761835 18279442 17869086 18205269 15123356 14724832 18251166 17944888 12741479 13678700 18277467 16011737 18412020 17565644 17481882 12649538 14620537 15650968 12666154 15370692 14716496 17823541 16116963 16638106 14512876 18317297 15052691 17922224 12445418 17698563 18054572 16015684 15925388 12389079 18006644 15893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.5318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.5315474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.5317347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.5312878042
MESH:D008107 Liver Diseases Acetaminophen 6.2816610002 16611625 12587719 19014921 11587558 12969438 19784758 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2816246199 15830285 17285989 15720792 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.2819363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5217347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0216899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.3420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.3419294768
MESH:D008113 Liver Neoplasms Phenobarbital 17.348742319 19482888 19073162 19812893 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 17.3415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 17.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.3416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.331399818 17172636 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3312151625
MESH:D008175 Lung Neoplasms marker/mechanism 2305558
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.2617053015 20464547 18520028 18816296 20869020 18569708 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms Tamoxifen 3.2618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2611884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.0016827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0014580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.4219453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008569 Memory Disorders Ethanol 4.0618411066 15451040
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2717261469
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7318551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6111141357
MESH:D009369 Neoplasms pirinixic acid 4.6117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8719189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
OMIM:601634 NEURAL TUBE DEFECTS, FOLATE-SENSITIVE Methanol 6.378946559
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7618514411
MESH:D009669 Nose Neoplasms 1,4-dioxane 5.939385384
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3116049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.2317016548
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.3112384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.512563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6917024972
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1815861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012640 Seizures 2,4-dinitrotoluene 9.3818551238
MESH:D012640 Seizures Ethanol 9.389754883
MESH:D012640 Seizures Phenobarbital 9.383137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
OMIM:102700 SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-NEGATIVE, DUE TO ADENOSINE DEAMINASE DEFICIENCY marker/mechanism
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.2719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.1316709447
MESH:D013088 Spermatocele Tamoxifen 11.1316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9119457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5020155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 2.5018456281
MESH:D013276 Stomach Ulcer Ethanol 3.4117189318 16755016 9211565 17918041 9562338 11906479
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.149754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.951399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9817053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.9816712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1810091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:05340 Primary immunodeficiency
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24503
    • No data
    Releated disease ID Related disease Name
    PA444519Hyperemia
    PA443434Arthritis, Rheumatoid
    PA443450Asthma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448048adenine
    PA450428methotrexate
    PA448049adenosine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00552 antagonist Pentostatin Antineoplastic Agents;Enzyme Inhibitors;Immunosuppressive Agents;Antibiotics
    DB00975 inhibitor Dipyridamole Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors
    DB02096 - FR221647
    DB02472 - 6-Hydroxy-7,8-Dihydro Purine Nucleoside
    DB02616 - FR117016
    DB02830 - FR236913
    DB03015 - 6-Hydroxy-1,6-Dihydro Purine Nucleoside
    DB03220 - FR233623
    DB03370 - FR239087
    DB03572 - FR230513
    DB04218 - 1-Deaza-Adenosine
    DB04440 - Purine Riboside Antineoplastic Agents;Anti-Bacterial Agents
    DB07711 - (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
    DB07783 - 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
    DB07785 - 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE
    DB07786 - 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
    Drugbank ID Action Drug Name Description
    DB00194 - Vidarabine Antiviral Agents;Antimetabolites
    DB00199 - T-Stat Pad-Lot Anti-Bacterial Agents;Macrolides
    DB00249 - Idoxuridine Antiviral Agents;Nucleic Acid Synthesis Inhibitors
    DB00277 - Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00640 - Adenosine Analgesics;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents;Cardiac drugs
    DB01280 substrate Nelarabine Antineoplastic Agents
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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