AutismKB 2.0

Annotation Detail for CDH2


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Basic Information Top
Gene Symbol:CDH2 ( CD325,CDHN,CDw325,NCAD )
Gene Full Name: cadherin 2, type 1, N-cadherin (neuronal)
Band: 18q12.1
Quick LinksEntrez ID:1000; OMIM: 114020; Uniprot ID:CADH2_HUMAN; ENSEMBL ID: ENSG00000170558; HGNC ID: 1759
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Myogenesis
Cell junction organization
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200189FGF signaling pathway
200180N-cadherin signaling events
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Cleft Palate
Tooth Abnormalities
DEVELOPMENTAL
Cleft Lip
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CDH2 mRNAdecreases expression 17547211
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CDH2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CDH2 mRNAincreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNAdecreases expression 12419474
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased expression of CDH2 proteindecreases expression 15082077
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased localization of CDH2 proteindecreases localization 15082077
D000082 Acetaminophen Acetaminophen affects the expression of CDH2 mRNAaffects expression 17562736
D019386 Alendronate Alendronate affects the expression of CDH2 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDH2 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of CDH2 mRNAincreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of CDH2 mRNA]decreases reaction|increases expression 12205029
D001374 Azacitidine Azacitidine results in increased expression of CDH2 mRNAincreases expression 18037191
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDH2 mRNAdecreases expression 19150397
C004541 biochanin A biochanin A results in decreased expression of CDH2 mRNAdecreases expression 12111696
C006780 bisphenol A bisphenol A results in decreased expression of CDH2 proteindecreases expression 15082077
C459604 candoxin candoxin results in increased expression of CDH2 mRNAincreases expression 16309724
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of CDH2 mRNAincreases expression 20105288
D003520 Cyclophosphamide Cyclophosphamide affects the expression of CDH2 mRNAaffects expression 10859244
D016572 Cyclosporine Cyclosporine results in decreased expression of CDH2 mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of CDH2 mRNAincreases expression 16367923
C014347 decitabine decitabine affects the methylation of CDH2 promoteraffects methylation 17959753
D004026 Dieldrin Dieldrin results in decreased expression of CDH2 proteindecreases expression 15082077
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of CDH2 proteinincreases expression 16678996
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of CDH2 proteinaffects cotreatment|affects expression 21163286
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CDH2 promoteraffects cotreatment|increases methylation 21163286
D004967 Estrogens Estrogens affects the expression of CDH2 mRNAaffects expression 15473135
D004967 Estrogens Estrogens affects the expression of CDH2 mRNAaffects expression 15473135
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDH2 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CDH2 mRNAdecreases expression 15834898
D019833 Genistein Genistein results in increased expression of CDH2 proteinincreases expression 16149052
D006072 Gossypol Gossypol results in decreased expression of CDH2 proteindecreases expression 15082077
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CDH2 mRNAdecreases expression 12419474
C027185 indirubin indirubin results in decreased expression of CDH2 mRNAdecreases expression 15056799
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of CDH2 proteinaffects cotreatment|affects expression 21163286
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CDH2 promoteraffects cotreatment|increases methylation 21163286
C020300 monomethylarsonic acid monomethylarsonic acid results in increased expression of CDH2 mRNAincreases expression 17481689
D009588 Nitrogen Mustard Compounds Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNAdecreases expression 18572855
D009588 Nitrogen Mustard Compounds Nitrogen Mustard Compounds results in decreased expression of CDH2 proteindecreases expression 18572855
D009588 Nitrogen Mustard Compounds Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA]decreases expression|decreases reaction 18572855
D009588 Nitrogen Mustard Compounds Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 protein]decreases expression|decreases reaction 18572855
C069741 norcantharidin norcantharidin results in decreased expression of CDH2 proteindecreases expression 15711181
D009675 Novobiocin Novobiocin results in decreased expression of CDH2 proteindecreases expression 11853877
D010634 Phenobarbital Phenobarbital affects the expression of CDH2 mRNAaffects expression 19482888
D010656 Phenylephrine Phenylephrine results in increased expression of CDH2 proteinincreases expression 17526999
D010672 Phenytoin Phenytoin results in decreased expression of CDH2 mRNAdecreases expression 9118846
D010936 Plant Extracts Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA]decreases expression|decreases reaction 18572855
D010936 Plant Extracts Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 protein]decreases expression|decreases reaction 18572855
D011374 Progesterone Progesterone results in decreased expression of CDH2 mRNAdecreases expression 17556502
D011794 Quercetin Quercetin results in increased expression of CDH2 mRNAincreases expression 15309432
D020849 Raloxifene Raloxifene affects the expression of CDH2 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of CDH2 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene Raloxifene affects the expression of CDH2 mRNAaffects expression 16079270
C116926 rofecoxib rofecoxib affects the expression of CDH2 mRNAaffects expression 17070997
C017947 sodium arsenite sodium arsenite affects the expression of CDH2 mRNAaffects expression 19590694
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CDH2 mRNAdecreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of CDH2 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of CDH2 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CDH2 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDH2 mRNAdecreases expression 16054898
18796159
D014212 Tretinoin Tretinoin results in increased expression of CDH2 mRNAincreases expression 18230668
D014212 Tretinoin Tretinoin results in increased expression of CDH2 proteinincreases expression 16149052
D014212 Tretinoin U 0126 inhibits the reaction [Tretinoin results in increased expression of CDH2 protein]decreases reaction|increases expression 16149052
D014212 Tretinoin Tretinoin affects the expression of CDH2 mRNAaffects expression 16211290
D014212 Tretinoin Tretinoin results in increased expression of CDH2 mRNAincreases expression 16236135
C052920 trimethylarsine oxide trimethylarsine oxide results in increased expression of CDH2 mRNAincreases expression 17481689
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNAaffects binding|increases expression 20105288
D014415 Tunicamycin Tunicamycin results in increased expression of CDH2 mRNAincreases expression 17127020
C113580 U 0126 U 0126 inhibits the reaction [Tretinoin results in increased expression of CDH2 protein]decreases reaction|increases expression 16149052
C025643 vinclozolin vinclozolin affects the expression of CDH2 mRNAaffects expression 19015723
D002762 Cholecalciferol Cholecalciferol results in increased expression of CDH2 mRNAincreases expression 17170073
C066436 zardaverine zardaverine results in decreased localization of CDH2 proteindecreases localization 15082077
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9814745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 15.896734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 15.896195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 15.896195326 9677735 9118846 8986270 3425630 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.8911752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.0118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.9317694057
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.7814692618
MESH:D000230 Adenocarcinoma Genistein 3.7811473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.233712494
MESH:D000236 Adenoma Diethylnitrosamine 9.2310737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 9.236695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.1316434500 17620307 17162532 19061943 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.1317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.1316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3317306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.0717451421 17308373
MESH:D000505 Alopecia Tretinoin 3.1715955085
MESH:D000544 Alzheimer Disease Plant Extracts 4.0516962711
MESH:D000544 Alzheimer Disease Raloxifene 4.0515800139
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.7410965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4611748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7417084956
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.2019015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6317460149
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.3715014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.3711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 14.6215885639
MESH:D001169 Arthritis, Experimental Plant Extracts 14.6214686799
MESH:D001169 Arthritis, Experimental rofecoxib 14.6216690336
MESH:D001169 Arthritis, Experimental Tretinoin 14.6216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1116292516
MESH:D001249 Asthma Tretinoin 2.1616456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4215336622
MESH:D050197 Atherosclerosis Methylcholanthrene 6.0411922910
MESH:D050197 Atherosclerosis Phenytoin 6.0415136057
MESH:D001321 Autistic Disorder Acetaminophen 1.4918445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 9.2616142846
MESH:D001327 Autoimmune Diseases Quercetin 9.2619761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.4511289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.2816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D001862 Bone Resorption bisphenol A 3.3711985600
MESH:D001919 Bradycardia Phenylephrine 3.9915306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7717868700
MESH:D001930 Brain Injuries Progesterone 9.1615665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 9.1616580743
MESH:D002545 Brain Ischemia Plant Extracts 4.1816041641
MESH:D001943 Breast Neoplasms bisphenol A 11.4217123778
MESH:D001943 Breast Neoplasms Cobalt 11.4215986119
MESH:D001943 Breast Neoplasms Cyclophosphamide 11.4217020986 18323546 12006526 11325840 15093573 17388661 15136595 18234424 16978400
MESH:D001943 Breast Neoplasms decitabine 11.4219208741 18320071
MESH:D001943 Breast Neoplasms Dieldrin 11.4211859874 15770527
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.4217474063
MESH:D001943 Breast Neoplasms Genistein 11.4216541309 17200150 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 11.4217474063
MESH:D001943 Breast Neoplasms Progesterone 11.4217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 11.4218628248
MESH:D001943 Breast Neoplasms Raloxifene 11.4216837676 15572757 17242785 15758505 16912660 17893378 15775269 17049068 17952589 17440819 17595753 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 11.4219288272 19059307 19487384 18815881 21138602 18629630 15668708 18351453 15565566 17893378 19115204 20135344 20544844 19244106 19221464 19066611 17049068 19189212 19410462 19142967 17261762 16818667 19103187 16202921 20005174 18821012 18984771 19155303 20859285 18997820 20390343 19084267 16873071 16273361 18425577 18855134 17440819 11161223 19200415 19189210 20065188 17242785 21152245 19011961 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.4220435547
MESH:D001943 Breast Neoplasms Tretinoin 11.4216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0316813970
MESH:D002057 Burns, Chemical Plant Extracts 4.779625245
MESH:D002105 Cadmium Poisoning Quercetin 4.9816962696
MESH:D002277 Carcinoma Methylcholanthrene 6.8610545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 29.3616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 29.367296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 29.363084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 29.3619701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 29.3616681979 16288022 18056438 21159647 17162532 19171122 20432363 17428255 18788625 16807293 18665156 20524982 20512989 18785209 10737359 17138121 20514400 19701751 19383236 17173139 20101231 19822196 18691550 16830150 19107877 3581430 18971187 20084675 16878318 11831363 19418558 16698587 18494052 19519916 20727157 18978308 10672840 19335982 17978847 20007298 18393292 16540662 17761372 16779866 16935385 19394651 20214788 20935162 19539802 18506893 19208518 16569478 3084413 19919837 17055752 16328049 19052882 18210153 16502159
MESH:D006528 Carcinoma, Hepatocellular Estrogens 29.3615341023
MESH:D006528 Carcinoma, Hepatocellular Genistein 29.3616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 29.3620935162 1701930 17173139 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 29.3618834353
MESH:D006528 Carcinoma, Hepatocellular Quercetin 29.3619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 29.3615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 29.3616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 29.361917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4317123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.3316152834
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4117234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.727296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 5.7216201981
MESH:D002294 Carcinoma, Squamous Cell decitabine 6.4319215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.4318572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.4316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.8917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.8917572228
MESH:D006332 Cardiomegaly Phenylephrine 13.6311754973 15728586 16170337 17124262 11179087 17287366
MESH:D006332 Cardiomegaly Plant Extracts 13.6317645561
MESH:D006332 Cardiomegaly Quercetin 13.6319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 13.6318670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 9.9516332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 9.9516936243
MESH:D002318 Cardiovascular Diseases Raloxifene 9.9515775269
MESH:D002386 Cataract Acetaminophen 6.0610977129
MESH:D002386 Cataract Tretinoin 6.0617460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.227505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.2220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.2212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.2217174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 21.2216192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.2219524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.864080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.864080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.9419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 10.9419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.9416105132 17110522 16919318 11677210 15861022 17333356 17681005
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.3111748493
MESH:D002822 Choriocarcinoma Tretinoin 4.5916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.2115894690
MESH:D002971 Cleft Lip Phenytoin 3.842227380
MESH:D002972 Cleft Palate Phenytoin 8.3810789828 3877104 6856622 6862529 2227380 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.3815668235 16354765 15340226 12621046 8697196
MESH:D002972 Cleft Palate Tretinoin 8.389407595
MESH:D003072 Cognition Disorders Raloxifene 4.0715800139
MESH:D003092 Colitis Tretinoin 3.1717035595
MESH:D003103 Coloboma Phenytoin 4.659212184
MESH:D003110 Colonic Neoplasms decitabine 7.2417616700
MESH:D003110 Colonic Neoplasms Genistein 7.2417182828
MESH:D003110 Colonic Neoplasms Quercetin 7.2415741050 19056647 16640504 17191121 19440933 11134977 17148506
MESH:D003110 Colonic Neoplasms rofecoxib 7.2412902858
MESH:D015179 Colorectal Neoplasms Azacitidine 3.2419934284
MESH:D015179 Colorectal Neoplasms decitabine 3.2418981723
MESH:D015179 Colorectal Neoplasms Quercetin 3.2418095365 18852136
MESH:D000013 Congenital Abnormalities Phenytoin 7.8210627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.8217141729 14669216
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.4519952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.459224671 9125849 9142499 9664655 16925845 14991402 9211117 10589399 8800419 17551590
MESH:D016638 Critical Illness Estrogens 5.3916670151
MESH:D003456 Cryptorchidism vinclozolin 3.8114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.4718551238
MESH:D003556 Cystitis Cyclophosphamide 4.4217010015 12388444 15643279 11948286 12913760 16989017 10498854 18093676 15276878 16413132 18710439 18372110 16614059 18295254 16651033 10700343 18433785 17979934 12161096 18483878
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6917474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.5211906362 11298694 14531868 8970840 12868966 2524372 8156756 18759878
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 5.5216823706 15059100 11298694
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.7616882537
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.982952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.3116285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.1515331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.1519496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0218772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.0916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.0917107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 12.4319706694
MESH:D003928 Diabetic Nephropathies Raloxifene 12.4315920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.4319279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9517187935
OMIM:607208 DRAVET SYNDROME Phenytoin 4.8411748493
MESH:D003875 Drug Eruptions Phenytoin 4.9615024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.617440962 18648102 16192314 9022650 1440618 6679447 18289764 8291058 9328219 18692083 11289319 9653073 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.6110774834 16109766 18713872 11287661 17562736 19923254 19370779 19085960 16485898 19420014 12392966 14986274 11529661 10915739 12153990 17522070 16393943 17906064 19164858 12958197 10663392 2444490 16781746 16081117 14725611 12594235 19416960 15968718 12705907 15619225 18071297 19739265 11739529 11421492 11743745 16177239 14550746 11834606 11461765 16227642 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.6119107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.6115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.6120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3411462148
MESH:D004421 Dystonia Phenobarbital 3.491851702
MESH:D004487 Edema Plant Extracts 8.7712787963
MESH:D004487 Edema Raloxifene 8.7715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.7711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.0618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 23.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 23.1617654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 23.1617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 23.1615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 23.1619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.0316402032
MESH:D016889 Endometrial Neoplasms Genistein 10.2711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.2719155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 10.2716569247
MESH:D004715 Endometriosis Progesterone 12.6016134523
MESH:D004715 Endometriosis rofecoxib 12.6015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.609294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.1115268973
MESH:D004802 Eosinophilia Cyclophosphamide 3.6811006010
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.6720235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.676251365 1399206
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.573659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.463922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 8.4617116037 11558140
MESH:D004827 Epilepsy Phenobarbital 9.4420417680
MESH:D004827 Epilepsy Phenytoin 9.4420417680 11434505 821787
MESH:D004827 Epilepsy Plant Extracts 9.4419700373 19439326
MESH:D004832 Epilepsy, Absence Phenobarbital 3.076401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.867750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 9.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.003659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 9.003659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 3.803581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.8020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.439664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 24.2919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2915345470
MESH:D005234 Fatty Liver Plant Extracts 24.2915975614
MESH:D005234 Fatty Liver Raloxifene 24.2917473493
MESH:D005234 Fatty Liver Tamoxifen 24.2919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8816709447
MESH:D005313 Fetal Death Phenytoin 8.9310627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.9311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.456705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6319069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.3814633661 10962813
MESH:D005355 Fibrosis Cyclosporine 16.7212639820 12168785
MESH:D005355 Fibrosis Quercetin 16.7219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.7220067830
MESH:D005355 Fibrosis Tretinoin 16.7217994277
MESH:D005706 Gallbladder Neoplasms norcantharidin 5.8716681930
MESH:D005756 Gastritis Acetaminophen 3.1116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 11.068708960
MESH:D005885 Gingival Hyperplasia Phenytoin 11.069029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.6714659971 16390469
MESH:D005909 Glioblastoma biochanin A 13.9116598420
MESH:D005909 Glioblastoma Genistein 13.9116598420
MESH:D005909 Glioblastoma Quercetin 13.9119804834
MESH:D005909 Glioblastoma Tretinoin 13.9117312396
MESH:D005910 Glioma Quercetin 2.8117643826
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9611389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.527505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.4915172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms decitabine 6.5319215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.5316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.4714991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.1411110106
MESH:D006333 Heart Failure Plant Extracts 3.5118097624
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8615720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.7511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.9714986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.996705139
MESH:D006529 Hepatomegaly Phenobarbital 6.6516109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.6512621046 16120746 15340226
MESH:D006561 Herpes Simplex Plant Extracts 4.0710715843
MESH:D015658 HIV Infections Plant Extracts 3.3712878215
MESH:D006689 Hodgkin Disease Cyclophosphamide 9.9016135485 17606976
MESH:D006689 Hodgkin Disease Nitrogen Mustard Compounds 9.9016794504
MESH:D006689 Hodgkin Disease sodium arsenite 9.9012676792
MESH:D019584 Hot Flashes Plant Extracts 4.1816566672 14716179 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.488697196 18606429 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 10.6416870215
MESH:D006930 Hyperalgesia Alendronate 10.6416769263
MESH:D006930 Hyperalgesia Tretinoin 10.6416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0216778211
MESH:D006943 Hyperglycemia Quercetin 3.5518262572 11834736
MESH:D020138 Hyperhomocysteinemia Phenytoin 8.2410459572
MESH:D020138 Hyperhomocysteinemia Plant Extracts 8.2416484555
MESH:D006949 Hyperlipidemias Plant Extracts 3.9615268973 15975614
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4015034207
MESH:D006968 Hypersensitivity, Delayed indirubin 5.3711275354
MESH:D006973 Hypertension Cobalt 17.4117039479
MESH:D006973 Hypertension Cyclosporine 17.4110903974
MESH:D006973 Hypertension Phenylephrine 17.418949925 12717712
MESH:D006973 Hypertension Quercetin 17.4118356687
MESH:D006973 Hypertension Raloxifene 17.4115787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 17.4118670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.0518502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2716569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 4.7616076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8615869954
MESH:D007247 Infertility, Female Dieldrin 8.5810630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.5812013081
MESH:D007248 Infertility, Male Cyclophosphamide 21.3716517039 7193160
MESH:D007248 Infertility, Male decitabine 21.3717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 21.3717937319
MESH:D007248 Infertility, Male Gossypol 21.3711202417 9639145
MESH:D007248 Infertility, Male sodium arsenite 21.3715346721 12646999
MESH:D007248 Infertility, Male vinclozolin 21.3716467254
MESH:D007249 Inflammation Diethylnitrosamine 12.5118785209
MESH:D007249 Inflammation Plant Extracts 12.5112787963 19332304 16366677 15997105
MESH:D007249 Inflammation Progesterone 12.5115869954
MESH:D007249 Inflammation Tamoxifen 12.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5112878042 12200463
MESH:D007251 Influenza, Human Quercetin 3.9416624496
MESH:D007333 Insulin Resistance bisphenol A 6.2916393666
MESH:D007333 Insulin Resistance Sodium Selenite 6.2914714311
MESH:D007410 Intestinal Diseases rofecoxib 8.3515831440
MESH:D007410 Intestinal Diseases Tretinoin 8.3517994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.1312351151 12628509 12584176
MESH:D007417 Intestinal Polyps rofecoxib 4.8511245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.458074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2717551590 15992940
MESH:D007627 Keloid Quercetin 4.4117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8715604871
MESH:D007674 Kidney Diseases Acetaminophen 11.6112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 11.618314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 11.6116962696
MESH:D007674 Kidney Diseases sodium arsenite 11.6120008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.7716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.016582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.0112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 14.0118625569
MESH:D007889 Leiomyoma Raloxifene 3.9816973256
MESH:D007938 Leukemia Azacitidine 20.6819148494
MESH:D007938 Leukemia Cyclophosphamide 20.6810602166
MESH:D007938 Leukemia decitabine 20.6818980019 19235587
MESH:D007938 Leukemia Genistein 20.6817468513 18980019
MESH:D007938 Leukemia Quercetin 20.6817468513
MESH:D007938 Leukemia Tretinoin 20.6817143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2417658394 17802794 17296974 18172266 18587576 17008537
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.7516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.6710373061
MESH:D007951 Leukemia, Myeloid Azacitidine 13.2319077051
MESH:D007951 Leukemia, Myeloid decitabine 13.2318454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 13.2316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 5.4817596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.4817679729 18206229 18460780 19387464 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.4817596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8918055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.6819299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.7716823087 9834237 17649720 16331271 17294898 16788101 19029980 17712046 17506722 19642359 16891316 19075265 19225113 16766008 17361223 17107899 12679006 15748426 16935935 17368321 16140955 17339181 17217047 19035177 17301526
MESH:D007970 Leukopenia Cyclophosphamide 4.4110052129 11830472
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.909224671
MESH:D008064 Lipidoses Tamoxifen 2.7517567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.2218407596 19638242 18665156 18522880 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 9.2221047994
MESH:D008103 Liver Cirrhosis Plant Extracts 9.2217157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Genistein 9.4717823541
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 9.4715479170
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 9.4712741479
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 9.4717565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.4718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.4718397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 10.6119784758 16610002 16611625 11587558 12969438 12587719 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 10.6117034775
MESH:D008107 Liver Diseases Phenobarbital 10.6119363144
MESH:D008107 Liver Diseases Phenytoin 10.6114986274
MESH:D008107 Liver Diseases Plant Extracts 10.6117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7517185352 16871587
MESH:D008113 Liver Neoplasms Dieldrin 25.248742319 9539021
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 25.2411940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.2420452335 19642983 18648771 20405173 19812893 19833225 15175105 20583210 19254457 20492335 18644402 21071580 18977376 9163691 12112319 21167192 20101389 21278145 18754104 19996281 15885732 16942905 19090486 10737359 18978307 19256749 20118626 12771043 19850985 21047994 20434301 19426721 20501860 20137499 19294768 19499222 2422723 19255062 19551842 19638242 19690152 19427195 19073162 2862719
MESH:D008113 Liver Neoplasms Phenobarbital 25.248742319 19073162 19482888 15975961 21047994 19812893
MESH:D008113 Liver Neoplasms Plant Extracts 25.2419168119
MESH:D008113 Liver Neoplasms Quercetin 25.2418980244
MESH:D008113 Liver Neoplasms sodium arsenite 25.2415276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 25.2416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.2416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.623712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.622563599 18079962 17854601 18544905 19519916 18775883 19009564 18282651 21159647 16842330 19539802 18093689 19004024 19126423 17174075 18164116 16267830 17942915 3124819 18253720 9362446 18308698
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.62598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.621399818 17172636 2563599 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.6219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.6212151625
MESH:D008171 Lung Diseases sodium arsenite 2.7919095001
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.326434250
MESH:D008175 Lung Neoplasms marker/mechanism 21163286
MESH:D008175 Lung Neoplasms Azacitidine 11.3321224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.336695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 11.3315390079 20512841 16271038 17909032 20970405 21163286 16337739 6695378 1399818 10545420 11893704 7750092 9230183
MESH:D008175 Lung Neoplasms Plant Extracts 11.3320869020
MESH:D008175 Lung Neoplasms Quercetin 11.3316280456
MESH:D008175 Lung Neoplasms sodium arsenite 11.3319931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 11.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.3319555203 11884234
MESH:D008223 Lymphoma Cyclophosphamide 6.5112854902
MESH:D008223 Lymphoma decitabine 6.5119470736
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 8.6816675587
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 8.6814737004
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7111911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2119428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 7.8614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.8611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 7.8619196722 19196723 11731420 16827153 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 3.9819453300
MESH:D008527 Medulloblastoma Tretinoin 2.5417453147
MESH:D008545 Melanoma decitabine 6.2216505122 17785578
MESH:D008545 Melanoma sodium arsenite 6.2216487513 19082730
MESH:D008545 Melanoma Tamoxifen 6.2219393235 12393984
MESH:D008545 Melanoma Tretinoin 6.2216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.0319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.0316388313
MESH:D008591 Meningomyelocele Tretinoin 3.8816940565
MESH:D008607 Mental Retardation Phenytoin 3.469212184
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.9915863610
MESH:D009006 Monosomy Azacitidine 5.5119299654
MESH:D009041 Motion Sickness Dextroamphetamine 4.951613127
MESH:D009101 Multiple Myeloma Azacitidine 9.9318443271 19549372
MESH:D009101 Multiple Myeloma decitabine 9.9318172295
MESH:D009101 Multiple Myeloma Raloxifene 9.9316497877
MESH:D009190 Myelodysplastic Syndromes Azacitidine 10.4719805378 17596541 18720364 17611569
MESH:D009190 Myelodysplastic Syndromes decitabine 10.4716882708 18608210 19157545 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.4717596541
MESH:D009203 Myocardial Infarction Genistein 5.1117141266
MESH:D009203 Myocardial Infarction Quercetin 5.1119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.2617141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.2619207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 10.6417484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 10.6417484760
MESH:D009224 Myotonia Congenita Phenytoin 4.851896199
MESH:D009232 Myxoma Raloxifene 4.9916343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 11.563581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.563581430 9029167
MESH:D009362 Neoplasm Metastasis norcantharidin 11.5615711181
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.5619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms Cyclophosphamide 15.8618854779
MESH:D009369 Neoplasms decitabine 15.8619116145 17925555 19470736
MESH:D009369 Neoplasms Dieldrin 15.868820588
MESH:D009369 Neoplasms Quercetin 15.8615185748
MESH:D009369 Neoplasms sodium arsenite 15.8611559025
MESH:D009369 Neoplasms Tretinoin 15.8616594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.1320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 19.1311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 19.1316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.1314600291
MESH:D009421 Nervous System Malformations Tretinoin 19.139125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.256679447
MESH:D009436 Neural Tube Defects Phenytoin 14.259118846
MESH:D009436 Neural Tube Defects sodium arsenite 14.2512854658
MESH:D009436 Neural Tube Defects Tretinoin 14.259142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.6417168769
MESH:D009447 Neuroblastoma Cyclophosphamide 3.3315176712 16115947 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.6620387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.338761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 3.8517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5520387270
MESH:D009503 Neutropenia Cyclophosphamide 3.828291058
MESH:D009765 Obesity Plant Extracts 2.9920132043 19056576
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.2712819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.274026338 6482804
MESH:D009845 Oligospermia Cyclophosphamide 4.1616517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.453988306
MESH:D010003 Osteoarthritis rofecoxib 4.0216690336
MESH:D010018 Osteomalacia Phenobarbital 10.2217016548
MESH:D010018 Osteomalacia Phenytoin 10.2217016548
MESH:D010024 Osteoporosis Alendronate 10.0017882678
MESH:D010024 Osteoporosis Genistein 10.0019401787
MESH:D010024 Osteoporosis Raloxifene 10.0019059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.9316169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.9319495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 13.9317893378 17823083 15758505 15579764
MESH:D010049 Ovarian Diseases bisphenol A 4.4311985600
MESH:D010051 Ovarian Neoplasms decitabine 19.6919331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 19.6919005980
MESH:D010051 Ovarian Neoplasms Progesterone 19.6916525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 19.6919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 19.6915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 19.6916936753
MESH:D010051 Ovarian Neoplasms U 0126 19.6916211241
MESH:D010146 Pain Acetaminophen 12.4516870215
MESH:D010146 Pain Cyclophosphamide 12.4512161096 18093676
MESH:D010146 Pain Phenytoin 12.4515215642
MESH:D010146 Pain Tretinoin 12.4516870215
MESH:D010149 Pain, Postoperative rofecoxib 4.8216678543 18165598
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 17.4511332152
MESH:D010190 Pancreatic Neoplasms decitabine 17.4519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.4516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 17.4516965848
MESH:D010190 Pancreatic Neoplasms Quercetin 17.4516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 17.4515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 12.537296757
MESH:D010212 Papilloma Hydrogen Peroxide 12.5312065085
MESH:D010212 Papilloma Plant Extracts 12.5316517061 15173996
MESH:D010300 Parkinson Disease Dieldrin 3.3016112328 11445065 11181820 17291500 16809432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 11.116228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 11.1111550810
MESH:D017689 Polydactyly Phenytoin 4.579212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Cyclosporine 18.0212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 18.022563599
MESH:D011230 Precancerous Conditions Phenobarbital 18.022563599
MESH:D011230 Precancerous Conditions Quercetin 18.0219056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.4721297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.0410548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.0411222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.0418220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.1817616702
MESH:D011469 Prostatic Diseases vinclozolin 4.3818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7120887781
MESH:D011471 Prostatic Neoplasms Azacitidine 4.5418324645
MESH:D011471 Prostatic Neoplasms biochanin A 4.5412111696
MESH:D011471 Prostatic Neoplasms bisphenol A 4.5416740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 4.5417024972
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 4.5417136230
MESH:D011471 Prostatic Neoplasms Genistein 4.5415378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Plant Extracts 4.5417804756 14666653
MESH:D011471 Prostatic Neoplasms Quercetin 4.5414715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 4.5416536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.5416039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 4.5418760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.5415067354
MESH:D011472 Prostatitis vinclozolin 4.3818629315
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7615861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.6712752131
MESH:D019310 Pseudolymphoma Phenytoin 10.678603615 1419762 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0116882103
MESH:D011625 Pterygium Tretinoin 4.2416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2310548101
MESH:D011658 Pulmonary Fibrosis Cobalt 5.586434250
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.5816636934
MESH:D011693 Purpura Raloxifene 4.9915770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.953692021
MESH:D012208 Rhabdomyosarcoma decitabine 9.2419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.2416116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012554 Schistosomiasis japonica Quercetin 4.9816862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3116636934
MESH:D012640 Seizures 2,4-dinitrotoluene 7.7118551238
MESH:D012640 Seizures Phenobarbital 7.7116876388 3137016 11442880 4039156
MESH:D012640 Seizures Phenytoin 7.713691417 15946322 19919933 10029267 16876388 11044598 9844417 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.266407741
MESH:D012852 Sinusitis Phenylephrine 4.157327846
MESH:D012871 Skin Diseases monomethylarsonic acid 3.8521378128
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.8412065085
MESH:D012878 Skin Neoplasms Plant Extracts 14.8415173996 16517061
MESH:D012878 Skin Neoplasms sodium arsenite 14.8418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.8416192470
MESH:D012878 Skin Neoplasms Tretinoin 14.8416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.6716709447
MESH:D013088 Spermatocele Tamoxifen 9.6716709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9616517039
MESH:D013119 Spinal Cord Injuries Progesterone 9.0216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.0219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3612854658
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.6120235791
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms decitabine 3.0119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.0118456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.0117261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.4218193104 12787963 18237397 17135157 15255614
MESH:D020521 Stroke Raloxifene 3.3816837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.4316045194 16684133
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5012837982
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.9117997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.926587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms decitabine 17.9217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.927505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.921399818
MESH:D013964 Thyroid Neoplasms Tretinoin 17.9216026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 4.6419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3016051514
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 24.0916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 24.098074119
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 24.0914692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 24.0919087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 24.0916720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 24.0917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 24.0917306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 24.0916712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7610091137
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.8011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.8016129372
MESH:D014591 Uterine Diseases bisphenol A 4.4414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7714692618
MESH:D014604 Uveal Neoplasms decitabine 10.9417785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.9416752155
MESH:D014605 Uveitis Cyclosporine 3.421336536
MESH:D014652 Vascular Diseases sodium arsenite 3.8717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.2118097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.7618097624
MESH:D014820 Vitiligo Tretinoin 3.5316761959
MESH:D014846 Vulvar Neoplasms Raloxifene 4.9916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
MESH:D014947 Wounds and Injuries Estrogens 7.6911172683
MESH:D014947 Wounds and Injuries Plant Extracts 7.6920213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 3.8717120751
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
REACT:21303 Myogenesis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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