AutismKB 2.0

Annotation Detail for ABI1


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Basic Information Top
Gene Symbol:ABI1 ( ABI-1,E3B1,NAP1BP,SSH3BP,SSH3BP1 )
Gene Full Name: abl-interactor 1
Band: 10p12.1
Quick LinksEntrez ID:10006; OMIM: 603050; Uniprot ID:ABI1_HUMAN; ENSEMBL ID: ENSG00000136754; HGNC ID: 11320
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
200165Regulation of RAC1 activity
200113ErbB1 downstream signaling
200105E-cadherin signaling in the nascent adherens junction
200190RAC1 signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
1944Breast cancer
2051Leukemia
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABI1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ABI1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ABI1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABI1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABI1 mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ABI1 mRNAaffects expression 17555576
D005419 Flavonoids Flavonoids results in decreased expression of ABI1 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in increased expression of ABI1 mRNAincreases expression 15256057
D009151 Mustard Gas Mustard Gas results in increased expression of ABI1 mRNAincreases expression 15674843
C025643 vinclozolin vinclozolin affects the expression of ABI1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D000230 Adenocarcinoma Genistein 4.4811473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001943 Breast Neoplasms Genistein 2.5116541309 16873071 17200150
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2410378619 17687719
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.767296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.763084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7616924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002318 Cardiovascular Diseases Genistein 3.4216332659
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.289022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2811677210 17681005 16919318 16105132 17333356 15861022 17110522
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111298694 11906362 18759878 14531868 8970840 8156756 12868966 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.439328219 6679447 1440618 8291058 18289764 9022650 6482804 7440962 11289319 16192314 18692083 9653073 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4319739265 11739529 12958197 19370779 14986274 16177239 14725611 19085960 16781746 12392966 11834606 16109766 16227642 19420014 19416960 17562736 18071297 19164858 11461765 18713872 17522070 16081117 11421492 15968718 10915739 10774834 14550746 12594235 12705907 16485898 12153990 16393943 11287661 19923254 12540782 15619225 17906064 2444490 10663392 11743745 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema Mustard Gas 3.489260866 11402378 11428631 11428647
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4711473722
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9815345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Flavonoids 5.6117296493
MESH:D007249 Inflammation Mustard Gas 5.6116001271 17524151 11428647 11428620 9357497 9260866 11402378 8975870 11428631
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D007938 Leukemia Genistein 3.1018980019 17468513
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Acetaminophen 1.6612969438 12587719 19014921 19784758 19460945 11587558 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.631399818 3712494 598648 6587162
MESH:D008171 Lung Diseases Mustard Gas 3.5618702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.178781369 3148597
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0412929590 14578162
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009203 Myocardial Infarction Genistein 2.9217141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7917141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009421 Nervous System Malformations Genistein 4.2316427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009503 Neutropenia Mustard Gas 4.1516761898 7688884
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6419005980
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1318042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Genistein 3.4415256057 16925846 15378649
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 10.3316919318 15861022
MESH:D011537 Pruritus Mustard Gas 10.3318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817620002 17894541 17720292 17266442 10334151
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012871 Skin Diseases Mustard Gas 2.7515451306 16961503 12880345
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.017505956 6582329 6587162 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.218074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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