AutismKB 2.0

Annotation Detail for GNPDA1


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Basic Information Top
Gene Symbol:GNPDA1 ( GNP1,GNPDA,GNPI,GPI,HLN,KIAA0060 )
Gene Full Name: glucosamine-6-phosphate deaminase 1
Band: 5q31.3
Quick LinksEntrez ID:10007; OMIM: 601798; Uniprot ID:GNPI1_HUMAN; ENSEMBL ID: ENSG00000113552; HGNC ID: 4417
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6517N-acetylglucosamine degradation II
GLCMANNANAUT-PWYsuperpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation
GLUAMCAT-PWYN-acetylglucosamine degradation I
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P02756N-acetylglucosamine metabolism
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of GNPDA1 mRNAdecreases expression 16704987
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of GNPDA1 mRNAincreases expression 18687144
D016572 Cyclosporine Cyclosporine results in increased expression of GNPDA1 mRNAincreases expression 20106945
D009151 Mustard Gas Mustard Gas results in increased expression of GNPDA1 mRNAincreases expression 12884408
C006253 pirinixic acid pirinixic acid results in decreased expression of GNPDA1 mRNAdecreases expression 17426115
C010327 salinomycin salinomycin results in decreased expression of GNPDA1 mRNAdecreases expression 19682730
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GNPDA1 mRNAdecreases expression 15800033
C034613 triacsin C triacsin C results in decreased expression of GNPDA1 mRNAdecreases expression 16704987
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0118582451
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms salinomycin 2.3619682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15340226 16354765 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Arachidonic Acid 18.599599246 16716910 7990266 15177302 11698051 9831321
MESH:D004487 Edema Mustard Gas 18.599260866 11402378 11428647 11428631
MESH:D004487 Edema pirinixic acid 18.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005334 Fever Arachidonic Acid 4.8811852909
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3019772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 18606429 16354765 16959395 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007249 Inflammation Arachidonic Acid 9.1515177302 9831321 17371808
MESH:D007249 Inflammation Mustard Gas 9.1511428620 16001271 8975870 11428647 9260866 11402378 17524151 11428631 9357497
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008113 Liver Neoplasms pirinixic acid 4.5116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms Mustard Gas 2.463148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.9119682730
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2616166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009503 Neutropenia Mustard Gas 4.237688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311399792 11896295 11222880 11118676
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.1717365031 17975199 17322281 15814490
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.1717894541 17620002 10334151 17720292 17266442
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 16961503 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28796
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02379 - Beta-D-Glucose Sweetening Agents
    DB02445 - 2-Deoxy-2-Amino Glucitol-6-Phosphate
    DB03951 - 16g
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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