AutismKB 2.0

Annotation Detail for CDH3


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Basic Information Top
Gene Symbol:CDH3 ( CDHP,HJMD,PCAD )
Gene Full Name: cadherin 3, type 1, P-cadherin (placental)
Band: 16q22.1
Quick LinksEntrez ID:1001; OMIM: 114021; Uniprot ID:CADH3_HUMAN; ENSEMBL ID: ENSG00000062038; HGNC ID: 1762
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Ectodermal dysplasia, ectrodactyly, and macular dystrophy
Hypotrichosis, congenital, with juvenile macular dystrophy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CDH3 mRNAincreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CDH3 mRNAdecreases expression 12419474
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in increased expression of CDH3 mRNAincreases expression 15135645
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDH3 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH3 mRNAaffects cotreatment|increases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CDH3 mRNAdecreases expression 12419474
D003520 Cyclophosphamide Cyclophosphamide affects the expression of CDH3 mRNAaffects expression 10859244
D002945 Cisplatin CDH3 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH3 mRNAaffects cotreatment|increases expression 18164116
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CDH3 mRNAincreases expression 17187413
D005492 Folic Acid Folic Acid results in increased expression of CDH3 mRNAincreases expression 17868486
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CDH3 mRNAdecreases expression 12419474
D007052 Ibuprofen Ibuprofen affects the expression of CDH3 mRNAaffects expression 17070997
D011691 Puromycin Puromycin results in decreased expression of CDH3 mRNAdecreases expression 15673299
C116926 rofecoxib rofecoxib results in increased expression of CDH3 mRNAincreases expression 17070997
D012643 Selenium Selenium results in increased expression of CDH3 mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in decreased expression of CDH3 mRNAdecreases expression 16604517
D014810 Vitamin E Vitamin E results in increased expression of CDH3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D058186 Acute Kidney Injury Cisplatin 14.4317670903 12690470 15814532
MESH:D058186 Acute Kidney Injury Folic Acid 14.4316316344 16595132 17003819
MESH:D058186 Acute Kidney Injury Ibuprofen 14.436375363
MESH:D000230 Adenocarcinoma Cisplatin 4.9511798837 17638652
MESH:D000230 Adenocarcinoma Ibuprofen 4.9510697514
MESH:D000236 Adenoma 2-Acetylaminofluorene 20.7910737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 20.793712494
MESH:D000236 Adenoma beta-Naphthoflavone 20.7919389873
MESH:D000236 Adenoma Diethylnitrosamine 20.7910737359 6695378
MESH:D000236 Adenoma Folic Acid 20.7916963246
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.986705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.8616434500 17620307 19061943 17162532 19052882 18056438
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease Folic Acid 4.7917116317
MESH:D000544 Alzheimer Disease Ibuprofen 4.7918351690
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0710965797
MESH:D000707 Anaphylaxis Ibuprofen 5.219532969
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.5615014928
MESH:D001169 Arthritis, Experimental rofecoxib 7.7316690336
MESH:D001169 Arthritis, Experimental Tretinoin 7.7316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D001321 Autistic Disorder Folic Acid 2.8321388746
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.5716206674 16197459
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8614601052
MESH:D002545 Brain Ischemia Ibuprofen 4.8515837124
MESH:D001943 Breast Neoplasms Cisplatin 2.3619526202 18382427
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.3618323546 18234424 17020986 17388661 16978400 11325840 15093573 12006526 15136595
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3617474063
MESH:D001943 Breast Neoplasms Folic Acid 2.3616777985
MESH:D001943 Breast Neoplasms Tretinoin 2.3616443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002100 Cachexia Ibuprofen 5.4315141370
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8916050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.326705139 3084413 3581430 10737359 17761372
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.323581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 11.3217982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 11.3219701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.3216502159 17162532 17978847 19519916 20727157 20512989 19208518 19822196 16878318 19418558 16328049 18785209 19919837 10737359 17138121 17428255 19539802 18665156 17173139 16807293 16935385 11831363 17055752 18971187 16540662 16779866 18978308 21159647 19171122 20084675 16698587 18691550 20214788 16681979 16830150 18056438 18506893 20524982 16288022 20432363 19701751 18494052 18788625 19394651 10672840 19107877 20514400 19383236 16569478 20101231 19052882 20935162 19335982 20007298 18210153 3084413 17761372 3581430 18393292
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.321917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.8516152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0216685392 12023789
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.627296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.6216201981
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.8117066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8116051514 16096774
MESH:D002318 Cardiovascular Diseases Folic Acid 7.6616755160
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.6616936243
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.597505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.597505956 17174075 21159647 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6519052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.119022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002971 Cleft Lip Folic Acid 3.9621254359
MESH:D002972 Cleft Palate Folic Acid 6.2421254359 8946559
MESH:D002972 Cleft Palate Tretinoin 6.249407595
MESH:D003092 Colitis Selenium 9.3717936198
MESH:D003092 Colitis Tretinoin 9.3717035595
MESH:D003093 Colitis, Ulcerative marker/mechanism 19915572
MESH:D003110 Colonic Neoplasms rofecoxib 3.2912902858
MESH:D015179 Colorectal Neoplasms Cisplatin 2.9715273666
MESH:D015179 Colorectal Neoplasms Folic Acid 2.9717245555 17116713 17087956 16963246 16985020
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.6817551590 9125849 16925845 9211117 8800419 14991402 10589399 9664655 9142499 9224671
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.6819769572
MESH:D003556 Cystitis Cyclophosphamide 4.9618372110 10498854 16413132 16989017 12388444 18710439 18433785 15276878 12913760 16614059 15643279 11948286 18295254 12161096 18483878 16651033 17979934 17010015 10700343 18093676
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7712868966 11298694 11906362 18759878 8156756 2524372 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.452952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.0311751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2118772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7220387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.7216886840
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.1918289764 6679447 11289319 18692083 6482804 7440962 9328219 18648102 8291058 9653073 1440618 16192314 9022650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.1915131321
MESH:D004362 Drug Toxicity Cisplatin 3.8219839026 15033597 12231392 12649298
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.5818446180 18450898 16133044
MESH:C538011 Eales disease Vitamin E 4.689068938
MESH:D004489 Edema, Cardiac Tretinoin 4.4418230668
OMIM:225280 EEM SYNDROME marker/mechanism
MESH:D016889 Endometrial Neoplasms Folic Acid 7.6917301261
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6916569247
MESH:D004715 Endometriosis Ibuprofen 9.7815652904
MESH:D004715 Endometriosis rofecoxib 9.7815652904
MESH:D019446 Endotoxemia Ibuprofen 4.9311545620
MESH:D004802 Eosinophilia Cyclophosphamide 4.1811006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.613581430
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6116481741 17638652 15173087 16785472 15464296
MESH:D017889 Exfoliation Syndrome Folic Acid 5.4616504073
MESH:D005124 Eye Abnormalities Tretinoin 3.5416938888 9664655
MESH:D005234 Fatty Liver Diethylnitrosamine 3.1521071580 20387270
MESH:D005334 Fever Ibuprofen 4.5416997862
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D005355 Fibrosis Tretinoin 3.4717994277
MESH:D005756 Gastritis Folic Acid 5.0617171786
MESH:D005901 Glaucoma Folic Acid 5.0416504073
MESH:D005909 Glioblastoma Tretinoin 2.9817312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.4811389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.0015172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.8115102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.8116096774
MESH:D034381 Hearing Loss Cisplatin 4.2619898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3815464296
MESH:D006330 Heart Defects, Congenital Folic Acid 11.2017286298 16524890
MESH:D006330 Heart Defects, Congenital Tretinoin 11.209664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2016080930
MESH:D006333 Heart Failure Selenium 3.0517162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.296705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.366705139
MESH:D006467 Hemophilia A Cyclophosphamide 5.2511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.5114986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.476705139
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916863852 16490937
MESH:D006679 HIV Seropositivity Folic Acid 5.4617209195
MESH:D006689 Hodgkin Disease Cisplatin 7.6516170182 16200630
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.6517606976 16135485
MESH:D019584 Hot Flashes Vitamin E 3.9414716179
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.4616865747 16433478 16755160 16395265 16397167
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006984 Hypertrophy Ibuprofen 4.9316672835
OMIM:601553 HYPOTRICHOSIS, CONGENITAL, WITH JUVENILE MACULAR DYSTROPHY marker/mechanism
MESH:D007154 Immune System Diseases Cyclophosphamide 5.3016076520
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.8116133044
MESH:D007248 Infertility, Male Cyclophosphamide 3.5916517039 7193160
MESH:D007249 Inflammation Diethylnitrosamine 5.4018785209
MESH:D007249 Inflammation Ibuprofen 5.403291741
MESH:D007251 Influenza, Human Selenium 10.8616624496
MESH:D007251 Influenza, Human Vitamin E 10.8616624496
MESH:D007410 Intestinal Diseases rofecoxib 10.0215831440
MESH:D007410 Intestinal Diseases Tretinoin 10.0217994277
MESH:D007417 Intestinal Polyps rofecoxib 5.3311245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 3.8615992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.1115464296
MESH:D007674 Kidney Diseases Cisplatin 6.2612649298 18289764 15190930 19839026 12231392
MESH:D007674 Kidney Diseases Vitamin E 6.2612488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.8916518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.8916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.936582329
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7711231351
MESH:D007938 Leukemia Cyclophosphamide 6.5110602166
MESH:D007938 Leukemia Tretinoin 6.5117143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4817296974 18172266 18587576 17008537 17802794 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0510373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1217361223 17506722 17294898 17368321 16823087 16331271 17339181 16935935 17107899 17301526 17712046 19075265 17649720 16766008 19642359 12679006 16891316 19225113 16140955 16788101 9834237 19029980 17217047 15748426 19035177
MESH:D007970 Leukopenia Cyclophosphamide 4.9311830472 10052129
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8018665156 19638242 20032147 18522880 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.6917565644
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6918397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6916169303
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3917034775
MESH:D008107 Liver Diseases Folic Acid 4.3916877991
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.5516273603 11376686 10672840 10737359 18001218 14678523
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.5521295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5520501860 20101389 19256749 19499222 19551842 19254457 20405173 19294768 20492335 19996281 9163691 19426721 10737359 19638242 19850985 21278145 20434301 15175105 19073162 19255062 19090486 21071580 2422723 19690152 15885732 12771043 20118626 19642983 18978307 12112319 21047994 2862719 19427195 20583210 19833225 20137499 16942905 21167192 18754104 18648771 20452335 18977376 19812893 18644402
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 13.971399818 534488 6150874
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.976587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.9718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.9716267830 3124819 16842330 18544905 18282651 18775883 19519916 19126423 9362446 18093689 19009564 18079962 19539802 2563599 17854601 18164116 18253720 19004024 18308698 17174075 21159647 17942915
MESH:D008171 Lung Diseases Vitamin E 3.1516863852
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 4.8911376686
MESH:D008175 Lung Neoplasms Cisplatin 4.896189445 11798837 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8921163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Vitamin E 4.8911062179
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3217718048
MESH:D008223 Lymphoma Cyclophosphamide 3.8012854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.5516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.1311911406
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 6.3510697514
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3515318939
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.6616832597
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Cisplatin 3.4812393984 15577323 16432458 17023156 18176117 18332650 18505091 12883367 16809738 16248763 12374674 17761969 11135225
MESH:D008545 Melanoma Tretinoin 3.4816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.7415990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.7616388313
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008654 Mesothelioma Cisplatin 6.3017638057
MESH:D008654 Mesothelioma Selenium 6.3015107826
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.643581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.643581430 9029167
MESH:D009369 Neoplasms Cisplatin 8.3316773208
MESH:D009369 Neoplasms Cyclophosphamide 8.3318854779
MESH:D009369 Neoplasms Tretinoin 8.3316946489 16594593
MESH:D009395 Nephritis, Interstitial Cisplatin 10.8215464296
MESH:D009395 Nephritis, Interstitial Ibuprofen 10.826375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.3510961664
MESH:D009421 Nervous System Malformations Tretinoin 3.749125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.076679447
MESH:D009436 Neural Tube Defects Folic Acid 12.0717438019
MESH:D009436 Neural Tube Defects Tretinoin 12.079142499
MESH:D009447 Neuroblastoma Cisplatin 7.218761367
MESH:D009447 Neuroblastoma Cyclophosphamide 7.2116115947 15176712 8761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3020387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 11.418761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 11.4112837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D009503 Neutropenia Cyclophosphamide 9.598291058
MESH:D009503 Neutropenia Folic Acid 9.5916322990
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009845 Oligospermia Cyclophosphamide 4.6816517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010003 Osteoarthritis Ibuprofen 8.217009135
MESH:D010003 Osteoarthritis rofecoxib 8.2116690336
MESH:D010051 Ovarian Neoplasms Cisplatin 5.006897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0016936753
MESH:D010146 Pain Cyclophosphamide 11.2918093676 12161096
MESH:D010146 Pain Ibuprofen 11.293291741
MESH:D010146 Pain Tretinoin 11.2916870215
MESH:D010149 Pain, Postoperative Ibuprofen 11.6416678543
MESH:D010149 Pain, Postoperative rofecoxib 11.6418165598 16678543
MESH:D010190 Pancreatic Neoplasms Cisplatin 16.1919003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 16.1911332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 16.1916540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 16.1912384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 16.1915976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.197296757
MESH:D010212 Papilloma Hydrogen Peroxide 9.1912065085
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2715464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.906228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.9011550810
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.3117638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.512563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7821297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.8217136230
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.8217409433
MESH:D011471 Prostatic Neoplasms Vitamin E 2.8215084515
MESH:D011507 Proteinuria Ibuprofen 9.376375363
MESH:D011507 Proteinuria Tretinoin 9.3716636307
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2616636934
MESH:D051437 Renal Insufficiency Cisplatin 10.4515464296
MESH:D051437 Renal Insufficiency Folic Acid 10.4515728788
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3914601052
MESH:D012559 Schizophrenia Folic Acid 2.8916641680
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7816636934
MESH:D012871 Skin Diseases Folic Acid 5.1918709164
MESH:D012871 Skin Diseases Vitamin E 5.1918709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.4512065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.458532709
MESH:D012878 Skin Neoplasms Tretinoin 9.4516467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.3115464296
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.4816517039
MESH:D013118 Spinal Cord Diseases Folic Acid 5.4616361298
MESH:D013274 Stomach Neoplasms Cisplatin 4.7517522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7518456281
MESH:D013274 Stomach Neoplasms Folic Acid 4.7517171786
MESH:D013274 Stomach Neoplasms Tretinoin 4.7517261132
MESH:D020521 Stroke Folic Acid 8.7816517955
MESH:D020521 Stroke Vitamin E 8.7816517955
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.0212837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.5917225452 15464296
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.756582329 3712494 6587162 7505956 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.757505956
MESH:D013964 Thyroid Neoplasms Tretinoin 11.7516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 11.8915867355 15289314 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.898074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.8912973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.8914692829
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.4416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.4416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5715577323
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.1519057314
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D014839 Vomiting Cisplatin 4.6911897121
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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