AutismKB 2.0

Annotation Detail for HDAC6


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Basic Information Top
Gene Symbol:HDAC6 ( FLJ16239,HD6 )
Gene Full Name: histone deacetylase 6
Band: Xp11.23
Quick LinksEntrez ID:10013; OMIM: 300272; Uniprot ID:HDAC6_HUMAN; ENSEMBL ID: ENSG00000094631; HGNC ID: 14064
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200019Signaling events mediated by HDAC Class II
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Related Diseases/Disorders Top
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Desease IDDesease Name
1809HIV infection
1944Breast cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HDAC6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HDAC6 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HDAC6 mRNAaffects expression 16483693
D002087 Butyrates Butyrates results in decreased activity of HDAC6 proteindecreases activity 15930892
C006963 chlamydocin chlamydocin analog results in decreased activity of HDAC6 proteindecreases activity 16439135
D004041 Dietary Fats Dietary Fats results in increased expression of HDAC6 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HDAC6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HDAC6 mRNAaffects cotreatment|decreases expression 17942748
C041786 palm oil palm oil results in increased expression of HDAC6 mRNAincreases expression 18042831
C016766 sulforafan HDAC6 protein inhibits the reaction [sulforafan results in decreased expression of AR protein]decreases expression|decreases reaction 19805354
C016766 sulforafan sulforafan results in decreased activity of HDAC6 proteindecreases activity 19805354
D013629 Tamoxifen Tamoxifen affects the expression of HDAC6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of HDAC6 mRNAaffects cotreatment|increases expression 19465110
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HDAC6 mRNAaffects cotreatment|decreases expression 17942748
C067071 trapoxin B trapoxin B results in decreased activity of HDAC6 proteindecreases activity 15930892
C012589 trichostatin A trichostatin A results in decreased activity of HDAC6 proteindecreases activity 15930892
C111237 vorinostat vorinostat results in decreased activity of HDAC6 proteindecreases activity 15930892
D015032 Zinc Zinc binds to and results in increased activity of HDAC6 proteinaffects binding|increases activity 16439135
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000169 Acrodermatitis Zinc 5.4517202136 17190629 16889938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D011125 Adenomatous Polyposis Coli sulforafan 5.2917942926
MESH:D000544 Alzheimer Disease Zinc 2.7617119284 16410023 16325427 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.9416916123
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001249 Asthma Zinc 2.9617085522
MESH:D001327 Autoimmune Diseases sulforafan 5.6219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001930 Brain Injuries Zinc 4.7317109824
MESH:D001943 Breast Neoplasms Dietary Fats 2.0020435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.0018351453 19288272 19221464 17261762 11161223 21152245 18629630 19200415 19142967 19103187 15565566 16873071 19155303 18425577 20544844 20390343 15668708 19066611 18855134 20005174 21138602 19487384 19115204 16818667 18815881 20065188 17893378 17049068 19189212 20859285 19084267 18821012 16202921 18984771 19410462 17242785 20135344 18997820 19011961 19289846 19189210 17440819 19244106 16273361 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001943 Breast Neoplasms vorinostat 2.0016144943
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5916705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.5916924424
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9116543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.6816936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.796135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8911677210 16919318 17333356 17681005 17110522 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115340226 15668235 8697196 16354765 12621046
MESH:D003110 Colonic Neoplasms Butyrates 3.0815936596
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 2.6819302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003920 Diabetes Mellitus Zinc 4.2316479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D003967 Diarrhea vorinostat 4.5320479100
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0719031437
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.7019294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0620544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004938 Esophageal Neoplasms Zinc 2.8616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005221 Fatigue vorinostat 5.6520479100
MESH:D005234 Fatty Liver Dietary Fats 13.2818296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2815345470
MESH:D005234 Fatty Liver Tamoxifen 13.2819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Dietary Fats 8.7618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7620067830
MESH:D005756 Gastritis Zinc 4.8617241300
MESH:D005909 Glioblastoma trichostatin A 3.8518801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006130 Growth Disorders Zinc 3.9817217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006333 Heart Failure Zinc 3.6217162251
MESH:D006335 Heart Injuries Zinc 5.8317074742
MESH:D016481 Helicobacter Infections Zinc 4.5617241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.7317276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9316120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 18606429 15340226 16354765 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Dietary Fats 8.3620412841
MESH:D007249 Inflammation Tamoxifen 8.3619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3612200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1211836018 18457598
MESH:D007511 Ischemia Zinc 4.6716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Zinc 3.3316960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.4516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.5516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5516705839
MESH:D007680 Kidney Neoplasms Tamoxifen 12.5518625569
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 2.9118206229
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2912878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.447678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.4416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.792876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7912151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2519555203 11884234
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.7320479100
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.3014580682 19196723 11731420 16827153 19196722
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.3012773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Tamoxifen 3.6019393235 12393984
MESH:D008545 Melanoma trichostatin A 3.6016505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D009101 Multiple Myeloma trichostatin A 3.8918172295
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009325 Nausea vorinostat 5.5920479100
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009765 Obesity Dietary Fats 2.2921332399 20518802 17217161 11836018 16723640 20132043 18457598 18674790 19632207
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010051 Ovarian Neoplasms trichostatin A 3.1819331143
MESH:D010190 Pancreatic Neoplasms trichostatin A 3.3019294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011225 Pre-Eclampsia Zinc 4.1917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411399792 11118676 11222880 11896295
MESH:D055728 Primary Myelofibrosis trichostatin A 5.2917616702
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2015067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.2019789329 18798265
MESH:D011471 Prostatic Neoplasms vorinostat 2.2017218635
MESH:D011471 Prostatic Neoplasms Zinc 2.2016606632 12429649 16700911 16517595
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration Zinc 4.1516584753
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013921 Thrombocytopenia vorinostat 5.0020479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Butyrates 4.0917967635
MESH:D014062 Tongue Neoplasms Zinc 4.4216543248
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3516049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3517572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29231
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02546 antagonist Vorinostat Antineoplastic Agents;Enzyme Inhibitors;Anticarcinogenic Agents
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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