AutismKB 2.0

Annotation Detail for PDCD6IP


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Basic Information Top
Gene Symbol:PDCD6IP ( AIP1,Alix,DRIP4,HP95,MGC17003 )
Gene Full Name: programmed cell death 6 interacting protein
Band: 3p22.3
Quick LinksEntrez ID:10015; OMIM: 608074; Uniprot ID:PDC6I_HUMAN; ENSEMBL ID: ENSG00000170248; HGNC ID: 8766
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1910Infantile spasms
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDCD6IP mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PDCD6IP mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PDCD6IP mRNAincreases expression 16788091
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PDCD6IP mRNAdecreases expression 20064835
D004041 Dietary Fats Dietary Fats results in decreased expression of PDCD6IP mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of PDCD6IP mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PDCD6IP mRNAincreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of PDCD6IP mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil results in decreased expression of PDCD6IP mRNAdecreases expression 17039268
D019833 Genistein Genistein results in increased expression of PDCD6IP mRNAincreases expression 18847459
D015741 Metribolone Metribolone results in decreased expression of PDCD6IP proteindecreases expression 17152098
C041786 palm oil palm oil results in decreased expression of PDCD6IP mRNAdecreases expression 18042831
D014501 Uranium Uranium affects the expression of PDCD6IP mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of PDCD6IP mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin affects the expression of PDCD6IP mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.2420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.2414692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.2417638652
MESH:D000230 Adenocarcinoma Genistein 10.2411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.676695378
MESH:D000740 Anemia Fluorouracil 3.7415504547 16511603 17963324
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3620146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.3611237771
MESH:D001943 Breast Neoplasms Dietary Fats 2.3620435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.3616557594 15136595 18357371 19217205 18608205 16110121 16595493
MESH:D001943 Breast Neoplasms Genistein 2.3616541309 16873071 17200150
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 3.5917121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6316705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6317971768 18930000 16332177 16799960 17045692 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6316924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.6211237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.6216280240 16757204 18986760 17066447
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.796135515
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8911677210 16919318 17333356 16105132 17110522 17681005 15861022
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8717018589 17725105 18772588 16510598 17169374 15001691 16340194 17016597 17287894 17172411
MESH:D003110 Colonic Neoplasms Genistein 3.8717182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016331619 17094418 20501625 15289873 16282729 16391804 18383874 18949393 18509181 18288408 17695437 18448328 16303861 14970324 16524972 15148649 17454858 17255274 17401013 17594712 18802399 17016601
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.8821346803 18551238
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.2115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2112538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3811473722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5116337965 16785472 15173087 16481741 17638652
MESH:D005234 Fatty Liver Dietary Fats 7.8217967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8215345470
MESH:D005355 Fibrosis Dietary Fats 3.5718296743
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D005910 Glioma Fluorouracil 2.8816145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4015102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6720471113
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7217937319
MESH:D007248 Infertility, Male vinclozolin 6.7216467254
MESH:D007249 Inflammation Dietary Fats 5.2520412841
MESH:D007249 Inflammation Flavonoids 5.2517296493
MESH:D007333 Insulin Resistance Dietary Fats 3.1218457598 11836018
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.5816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5816705839
MESH:D007680 Kidney Neoplasms Fluorouracil 12.5816985049
MESH:D007938 Leukemia Genistein 3.0418980019 17468513
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.527678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5220195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.5216603448 18383874 17045692 15113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.562876786 2876784 6135515
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4718816296 18569708 20464547 20869020 17053015 6695378 20135361 20064080 18520028
MESH:D008175 Lung Neoplasms Fluorouracil 2.4715246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9612929590 14578162
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6018986760 16757204
MESH:D009203 Myocardial Infarction Genistein 2.8717141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6817141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.5218551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1111141357
MESH:D009369 Neoplasms Fluorouracil 5.1118600527 16928823 18239605
MESH:D009421 Nervous System Malformations Genistein 4.0716427766
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D009765 Obesity Dietary Fats 2.2921332399 20518802 11836018 18457598 20132043 16723640 17217161 18674790 19632207
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6119005980
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6716929163 19003803 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9519015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8315572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0916289102 18247401 12479363 15754350 16644109
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0918626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.0915256057 16925846 15378649
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0418722050 16160472 18286688 15538739
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3810029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4317522103 17172411 18396642 18567086 16951190 17498489 19015929 15786421 16424979 19084572
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3317053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
Pathway ID Pathway Name
KEGG:04144 Endocytosis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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