Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of PDCD6 mRNA | affects expression | 21346803
|
D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDCD6 mRNA | decreases expression | 20018196
|
D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PDCD6 mRNA | increases expression | 20382639
|
D002995 |
Clofibric Acid |
[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNA | affects cotreatment|affects expression | 17602206
|
D003042 |
Cocaine |
Cocaine affects the expression of PDCD6 mRNA | affects expression | 15681117
|
D004052 |
Diethylnitrosamine |
[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNA | affects cotreatment|affects expression | 17602206
|
D004054 |
Diethylstilbestrol |
Diethylstilbestrol results in increased expression of PDCD6 mRNA | increases expression | 15766595
|
D004997 |
Ethinyl Estradiol |
Ethinyl Estradiol affects the expression of PDCD6 mRNA | affects expression | 17555576
|
D004997 |
Ethinyl Estradiol |
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNA | affects cotreatment|increases expression | 17942748
|
D009151 |
Mustard Gas |
Mustard Gas results in increased expression of PDCD6 mRNA | increases expression | 15674843
|
C017947 |
sodium arsenite |
sodium arsenite results in decreased expression of PDCD6 mRNA | decreases expression | 12760830
|
D013749 |
Tetrachlorodibenzodioxin |
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNA | affects cotreatment|increases expression | 17942748
|
C034028 |
vanadyl sulfate |
vanadyl sulfate results in increased expression of PDCD6 mRNA | increases expression | 16330358
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.04 | 11752688 15322242 14514962 |
MESH:D000152 |
Acne Vulgaris |
|
Ethinyl Estradiol |
4.16 | 17505938 |
MESH:D000230 |
Adenocarcinoma |
|
Ethinyl Estradiol |
1.84 | 14692618 |
MESH:D000236 |
Adenoma |
|
Diethylnitrosamine |
2.93 | 6695378 10737359 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Diethylnitrosamine |
10.71 | 17620307 19061943 16434500 19052882 18056438 17162532 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
10.71 | 16835633 |
MESH:D000310 |
Adrenal Gland Neoplasms |
|
sodium arsenite |
4.92 | 15276417 |
MESH:D018246 |
Adrenocortical Adenoma |
|
sodium arsenite |
5.12 | 17306315 16712894 |
MESH:D000686 |
Amyloidosis |
|
Diethylstilbestrol |
4.64 | 15469931 |
MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
3.08 | 11748828 |
MESH:D001161 |
Arteriosclerosis |
|
Ethinyl Estradiol |
3.64 | 11256880 |
MESH:D001169 |
Arthritis, Experimental |
|
Ethinyl Estradiol |
2.74 | 15885639 |
MESH:D001249 |
Asthma |
|
Mustard Gas |
2.75 | 10378619 |
MESH:D001768 |
Blister |
|
Mustard Gas |
5.35 | 19167455 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
3.18 | 12125929 |
MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.01 | 15340226 |
MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
2.85 | 15746008 |
MESH:D001943 |
Breast Neoplasms |
|
Diethylnitrosamine |
1.88 | 17474063 |
MESH:D001943 |
Breast Neoplasms |
|
Diethylstilbestrol |
1.88 | 17129689 15324884 |
MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.88 | 20435547 |
MESH:D001989 |
Bronchiolitis Obliterans |
|
Mustard Gas |
5.35 | 15286001 |
MESH:D029481 |
Bronchitis, Chronic |
|
Mustard Gas |
5.19 | 17687719 10378619 |
MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
2.91 | 16835633 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
6.77 | 16705839 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Diethylnitrosamine |
6.77 | 16935385 21159647 16328049 18971187 20214788 19394651 19919837 20084675 20727157 10737359 18506893 19539802 17173139 16807293 16288022 18691550 16830150 18393292 19208518 19107877 16540662 20101231 16502159 18210153 16569478 16698587 17138121 19052882 19171122 19383236 10672840 19418558 19701751 16779866 16878318 17428255 18978308 3084413 20514400 18665156 17978847 11831363 17761372 19822196 18788625 20935162 17055752 20007298 20432363 18785209 17162532 20512989 18494052 20524982 19519916 16681979 18056438 3581430 19335982 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Diethylstilbestrol |
6.77 | 16924424 15948411 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
sodium arsenite |
6.77 | 15276417 16507464 17306315 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
sodium arsenite |
2.41 | 18572023 |
MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.44 | 16120746 18850075 18670907 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
11.77 | 20889678 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
Diethylnitrosamine |
11.77 | 2727394 7505956 17174075 21159647 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
sodium arsenite |
11.77 | 19524636 20056578 |
MESH:D018281 |
Cholangiocarcinoma |
|
Diethylnitrosamine |
9.74 | 19052882 |
MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
9.74 | 16835633 |
MESH:D002779 |
Cholestasis |
|
Ethinyl Estradiol |
2.98 | 16105132 17681005 15861022 17333356 11677210 16919318 17110522 |
MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.15 | 15340226 15668235 16354765 12621046 8697196 |
MESH:D019970 |
Cocaine-Related Disorders |
|
Cocaine |
5.91 | 19606084 |
MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.18 | 14669216 17141729 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.26 | 15322242 20055451 10048152 |
MESH:D003456 |
Cryptorchidism |
|
Diethylstilbestrol |
4.72 | 16002989 12952375 |
MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
4.19 | 18551238 |
MESH:D003921 |
Diabetes Mellitus, Experimental |
|
vanadyl sulfate |
4.49 | 16684804 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Diethylnitrosamine |
4.32 | 20387270 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
4.32 | 17107852 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
6.40 | 18551238 21346803 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Diethylnitrosamine |
6.40 | 19107877 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
6.40 | 20420201 |
MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
2.86 | 11462148 |
MESH:D004487 |
Edema |
|
Mustard Gas |
7.31 | 11428647 11402378 11428631 9260866 |
MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
7.31 | 11000095 12711302 |
MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.12 | 18230668 15322242 16714409 |
MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Ethinyl Estradiol |
3.35 | 12538720 |
MESH:D004714 |
Endometrial Hyperplasia |
|
Diethylstilbestrol |
4.89 | 16402032 |
MESH:D016889 |
Endometrial Neoplasms |
|
Diethylstilbestrol |
3.55 | 16804899 15700306 |
MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.15 | 10568697 9294722 |
MESH:D004890 |
Erythema |
|
Mustard Gas |
5.35 | 9357497 |
MESH:D004931 |
Esophageal Achalasia |
|
Diethylnitrosamine |
5.33 | 16302075 |
MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.10 | 20426865 |
MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.12 | 11564622 |
MESH:D005234 |
Fatty Liver |
|
Diethylnitrosamine |
8.17 | 21071580 20387270 |
MESH:D005234 |
Fatty Liver |
|
Ethinyl Estradiol |
8.17 | 15345470 |
MESH:D052776 |
Female Urogenital Diseases |
|
Diethylstilbestrol |
3.73 | 16534752 16611131 15751030 16002989 16513791 |
MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
3.63 | 11858732 |
MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
3.12 | 20067830 |
MESH:D005833 |
Genital Neoplasms, Female |
|
Diethylstilbestrol |
13.47 | 16452187 |
MESH:D005833 |
Genital Neoplasms, Female |
|
sodium arsenite |
13.47 | 16452187 |
MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
4.81 | 10696789 |
MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
2.40 | 10048152 11294989 |
MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.48 | 11000095 |
MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
3.07 | 15340226 12621046 16120746 |
MESH:D006689 |
Hodgkin Disease |
|
sodium arsenite |
3.27 | 12676792 |
MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.26 | 16959395 18606429 16354765 15340226 8697196 |
MESH:D006965 |
Hyperplasia |
|
Diethylstilbestrol |
4.61 | 14722030 12960047 |
MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
1.95 | 18670907 18850075 |
MESH:D007021 |
Hypospadias |
|
Diethylstilbestrol |
11.84 | 16002989 |
MESH:D007021 |
Hypospadias |
|
Ethinyl Estradiol |
11.84 | 16945680 16569931 |
MESH:D007246 |
Infertility |
|
Diethylstilbestrol |
4.52 | 15036965 |
MESH:D007247 |
Infertility, Female |
|
Ethinyl Estradiol |
3.61 | 12013081 |
MESH:D007248 |
Infertility, Male |
|
Ethinyl Estradiol |
6.95 | 17937319 |
MESH:D007248 |
Infertility, Male |
|
sodium arsenite |
6.95 | 12646999 15346721 |
MESH:D007249 |
Inflammation |
|
Diethylnitrosamine |
8.73 | 18785209 |
MESH:D007249 |
Inflammation |
|
Mustard Gas |
8.73 | 11428647 11428620 11402378 17524151 11428631 8975870 9357497 9260866 16001271 |
MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
8.73 | 12200463 12878042 |
MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.48 | 16580747 |
MESH:D007674 |
Kidney Diseases |
|
sodium arsenite |
2.87 | 20008137 |
MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
7.93 | 16705839 |
MESH:D007680 |
Kidney Neoplasms |
|
Diethylstilbestrol |
7.93 | 15003126 14681315 16762066 |
MESH:D007859 |
Learning Disorders |
|
Diethylstilbestrol |
4.24 | 17184923 |
MESH:D008103 |
Liver Cirrhosis |
|
Diethylnitrosamine |
2.89 | 18522880 18407596 18665156 20032147 19638242 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
1.24 | 12878042 |
MESH:D008107 |
Liver Diseases |
|
Diethylnitrosamine |
2.13 | 17034775 |
MESH:D008113 |
Liver Neoplasms |
|
Clofibric Acid |
14.78 | 17602206 |
MESH:D008113 |
Liver Neoplasms |
|
Diethylnitrosamine |
14.78 | 21167192 18754104 20452335 9163691 19426721 20583210 21278145 19256749 19294768 20501860 20137499 21047994 19638242 19090486 19499222 15885732 12771043 18644402 15175105 19427195 19996281 10737359 19254457 20405173 19812893 19255062 2862719 19690152 20101389 18978307 21071580 19551842 12112319 16942905 19642983 2422723 18977376 20492335 18648771 19073162 19833225 20118626 20434301 19850985 |
MESH:D008113 |
Liver Neoplasms |
|
Diethylstilbestrol |
14.78 | 15890375 16712894 |
MESH:D008113 |
Liver Neoplasms |
|
sodium arsenite |
14.78 | 15276417 16712894 |
MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
14.78 | 16984957 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Diethylnitrosamine |
6.04 | 18164116 9362446 21159647 19539802 19126423 16842330 17174075 19009564 3124819 18775883 18253720 16267830 2563599 18308698 17942915 18544905 18093689 19519916 18282651 18079962 17854601 19004024 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
6.04 | 12151625 |
MESH:D008171 |
Lung Diseases |
|
Mustard Gas |
7.85 | 18702808 18161513 |
MESH:D008171 |
Lung Diseases |
|
sodium arsenite |
7.85 | 19095001 |
MESH:D008175 |
Lung Neoplasms |
|
Diethylnitrosamine |
4.97 | 20970405 6695378 20512841 21163286 |
MESH:D008175 |
Lung Neoplasms |
|
Mustard Gas |
4.97 | 3148597 8781369 |
MESH:D008175 |
Lung Neoplasms |
|
sodium arsenite |
4.97 | 15276417 17306315 17077188 16712894 19931552 |
MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
4.97 | 11884234 19555203 |
MESH:D008181 |
Lupus Nephritis |
|
Diethylstilbestrol |
5.34 | 15166399 |
MESH:D008223 |
Lymphoma |
|
Diethylstilbestrol |
3.57 | 15700306 |
MESH:D052801 |
Male Urogenital Diseases |
|
Diethylstilbestrol |
5.73 | 16002989 |
MESH:D008545 |
Melanoma |
|
sodium arsenite |
2.05 | 19082730 16487513 |
MESH:D009203 |
Myocardial Infarction |
|
Cocaine |
4.03 | 18072171 |
MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.13 | 12213967 |
MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
4.05 | 18551238 |
MESH:D009362 |
Neoplasm Metastasis |
|
Diethylnitrosamine |
2.61 | 9029167 3581430 |
MESH:D009369 |
Neoplasms |
|
Diethylstilbestrol |
5.45 | 15313581 |
MESH:D009369 |
Neoplasms |
|
sodium arsenite |
5.45 | 11559025 |
MESH:D009374 |
Neoplasms, Experimental |
|
sodium arsenite |
3.84 | 20056578 |
MESH:D009421 |
Nervous System Malformations |
|
Diethylstilbestrol |
10.19 | 11399458 |
MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
10.19 | 14600291 |
MESH:D009436 |
Neural Tube Defects |
|
sodium arsenite |
3.23 | 12854658 |
MESH:D019636 |
Neurodegenerative Diseases |
|
Diethylnitrosamine |
3.46 | 20387270 |
MESH:D009461 |
Neurologic Manifestations |
|
Diethylnitrosamine |
5.33 | 20387270 |
MESH:D009503 |
Neutropenia |
|
Mustard Gas |
4.12 | 16761898 7688884 |
MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
3.56 | 12819281 16049721 |
MESH:D010051 |
Ovarian Neoplasms |
|
sodium arsenite |
2.47 | 15276417 17306315 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Diethylnitrosamine |
2.46 | 16540662 |
MESH:D016584 |
Panic Disorder |
|
Ethinyl Estradiol |
3.84 | 11578682 |
MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
4.47 | 12520081 |
MESH:D010900 |
Pituitary Diseases |
|
Diethylstilbestrol |
5.39 | 14722030 |
MESH:D010911 |
Pituitary Neoplasms |
|
Diethylstilbestrol |
4.85 | 15687265 16977796 |
MESH:D011041 |
Poisoning |
|
Mustard Gas |
3.94 | 15727166 |
MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
3.72 | 18163543 |
MESH:D011230 |
Precancerous Conditions |
|
Diethylnitrosamine |
3.68 | 2563599 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Diethylstilbestrol |
10.22 | 17184923 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
10.22 | 11896295 11399792 11118676 11222880 |
MESH:D011471 |
Prostatic Neoplasms |
|
Diethylstilbestrol |
3.37 | 15046698 17136230 15846301 |
MESH:D011471 |
Prostatic Neoplasms |
|
sodium arsenite |
3.37 | 16039940 |
MESH:D011537 |
Pruritus |
|
Ethinyl Estradiol |
10.18 | 15861022 16919318 |
MESH:D011537 |
Pruritus |
|
Mustard Gas |
10.18 | 18058305 |
MESH:D011618 |
Psychotic Disorders |
|
Cocaine |
4.92 | 16134406 |
MESH:D011658 |
Pulmonary Fibrosis |
|
Mustard Gas |
2.97 | 17720292 17894541 10334151 17266442 17620002 |
MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.00 | 18990726 |
MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.73 | 18551238 |
MESH:D012640 |
Seizures |
|
Cocaine |
6.73 | 10454489 |
MESH:D012871 |
Skin Diseases |
|
Mustard Gas |
2.74 | 12880345 16961503 15451306 |
MESH:D012878 |
Skin Neoplasms |
|
sodium arsenite |
5.79 | 19524636 18572023 |
MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
5.79 | 16192470 |
MESH:D013088 |
Spermatocele |
|
Diethylstilbestrol |
12.45 | 16709447 16002989 |
MESH:D013088 |
Spermatocele |
|
Ethinyl Estradiol |
12.45 | 16709447 |
MESH:D016135 |
Spinal Dysraphism |
|
sodium arsenite |
3.90 | 12854658 |
MESH:D013274 |
Stomach Neoplasms |
|
Diethylnitrosamine |
1.76 | 18456281 |
MESH:D019851 |
Thrombophilia |
|
Ethinyl Estradiol |
3.77 | 11994571 |
MESH:D013927 |
Thrombosis |
|
Ethinyl Estradiol |
3.28 | 15669648 |
MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.12 | 12697716 |
MESH:D013964 |
Thyroid Neoplasms |
|
Diethylnitrosamine |
3.09 | 7505956 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
8.67 | 16049721 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Diethylstilbestrol |
8.67 | 17306315 16712894 16452187 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
sodium arsenite |
8.67 | 11723127 16712894 16452187 17306315 |
MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
4.51 | 10091137 |
MESH:D002583 |
Uterine Cervical Neoplasms |
|
Diethylstilbestrol |
9.98 | 16175088 |
MESH:D002583 |
Uterine Cervical Neoplasms |
|
sodium arsenite |
9.98 | 11813266 |
MESH:D014591 |
Uterine Diseases |
|
Diethylstilbestrol |
5.39 | 14652134 |
MESH:D014594 |
Uterine Neoplasms |
|
Diethylstilbestrol |
10.02 | 15809267 16690809 |
MESH:D014594 |
Uterine Neoplasms |
|
Ethinyl Estradiol |
10.02 | 14692618 |
MESH:D014625 |
Vaginal Neoplasms |
|
Diethylstilbestrol |
4.61 | 16002989 16513791 |
MESH:D014652 |
Vascular Diseases |
|
sodium arsenite |
4.62 | 17056641 |
MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
4.81 | 12125929 |
MESH:D020246 |
Venous Thrombosis |
|
Ethinyl Estradiol |
3.68 | 14671159 15869587 |
MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
4.47 | 15886252 |