AutismKB 2.0

Annotation Detail for PDCD6


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Basic Information Top
Gene Symbol:PDCD6 ( ALG-2,FLJ46208,MGC111017,MGC119050,MGC9123,PEF1B )
Gene Full Name: programmed cell death 6
Band: 5p15.33
Quick LinksEntrez ID:10016; OMIM: 601057; Uniprot ID:PDCD6_HUMAN; ENSEMBL ID: ENSG00000063438,ENSG00000249915; HGNC ID: 8765
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2066Lung cancer
2120Rabies
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDCD6 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDCD6 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PDCD6 mRNAincreases expression 20382639
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNAaffects cotreatment|affects expression 17602206
D003042 Cocaine Cocaine affects the expression of PDCD6 mRNAaffects expression 15681117
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PDCD6 mRNAincreases expression 15766595
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PDCD6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNAaffects cotreatment|increases expression 17942748
D009151 Mustard Gas Mustard Gas results in increased expression of PDCD6 mRNAincreases expression 15674843
C017947 sodium arsenite sodium arsenite results in decreased expression of PDCD6 mRNAdecreases expression 12760830
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNAaffects cotreatment|increases expression 17942748
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of PDCD6 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7117620307 19061943 16434500 19052882 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.8817129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7716935385 21159647 16328049 18971187 20214788 19394651 19919837 20084675 20727157 10737359 18506893 19539802 17173139 16807293 16288022 18691550 16830150 18393292 19208518 19107877 16540662 20101231 16502159 18210153 16569478 16698587 17138121 19052882 19171122 19383236 10672840 19418558 19701751 16779866 16878318 17428255 18978308 3084413 20514400 18665156 17978847 11831363 17761372 19822196 18788625 20935162 17055752 20007298 20432363 18785209 17162532 20512989 18494052 20524982 19519916 16681979 18056438 3581430 19335982
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.7716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7715276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7720889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.772727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7719524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9816105132 17681005 15861022 17333356 11677210 16919318 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 15668235 16354765 12621046 8697196
MESH:D019970 Cocaine-Related Disorders Cocaine 5.9119606084
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4916684804
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Mustard Gas 7.3111428647 11402378 11428631 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5516804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1715345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316534752 16611131 15751030 16002989 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.4716452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.4716452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 18606429 16354765 15340226 8697196
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6114722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 11.8416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.8416945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9517937319
MESH:D007248 Infertility, Male sodium arsenite 6.9512646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 8.7318785209
MESH:D007249 Inflammation Mustard Gas 8.7311428647 11428620 11402378 17524151 11428631 8975870 9357497 9260866 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases sodium arsenite 2.8720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9316705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.9315003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918522880 18407596 18665156 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms Clofibric Acid 14.7817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.7821167192 18754104 20452335 9163691 19426721 20583210 21278145 19256749 19294768 20501860 20137499 21047994 19638242 19090486 19499222 15885732 12771043 18644402 15175105 19427195 19996281 10737359 19254457 20405173 19812893 19255062 2862719 19690152 20101389 18978307 21071580 19551842 12112319 16942905 19642983 2422723 18977376 20492335 18648771 19073162 19833225 20118626 20434301 19850985
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.7815890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 14.7815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0418164116 9362446 21159647 19539802 19126423 16842330 17174075 19009564 3124819 18775883 18253720 16267830 2563599 18308698 17942915 18544905 18093689 19519916 18282651 18079962 17854601 19004024
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0412151625
MESH:D008171 Lung Diseases Mustard Gas 7.8518702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 7.8519095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 4.973148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 4.9715276417 17306315 17077188 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9711884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D009203 Myocardial Infarction Cocaine 4.0318072171
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009369 Neoplasms Diethylstilbestrol 5.4515313581
MESH:D009369 Neoplasms sodium arsenite 5.4511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.1911399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009503 Neutropenia Mustard Gas 4.1216761898 7688884
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5612819281 16049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4715276417 17306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8515687265 16977796
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.2217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2211896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3715046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3716039940
MESH:D011537 Pruritus Ethinyl Estradiol 10.1815861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.1818058305
MESH:D011618 Psychotic Disorders Cocaine 4.9216134406
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717720292 17894541 10334151 17266442 17620002
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7318551238
MESH:D012640 Seizures Cocaine 6.7310454489
MESH:D012871 Skin Diseases Mustard Gas 2.7412880345 16961503 15451306
MESH:D012878 Skin Neoplasms sodium arsenite 5.7919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7916192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.4516709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4516709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6716049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.6717306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.6711723127 16712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.9816175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.9811813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.0215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.0214692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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