Gene Symbol:	HCN4 ( SSS2 )
Gene Full Name:	hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Band:	15q24.1
Quick Links	Entrez ID:10021; OMIM: 605206; Uniprot ID:HCN4_HUMAN; ENSEMBL ID: ENSG00000138622; HGNC ID: 16882
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000638	Amiodarone	Amiodarone results in decreased expression of HCN4 mRNA	decreases expression	17711693
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HCN4 mRNA	affects expression	16483693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HCN4 mRNA	affects cotreatment\|increases expression	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HCN4 mRNA	affects cotreatment\|increases expression	18164116
C030691	gluconic acid	gluconic acid results in increased expression of HCN4 mRNA	increases expression	16556975

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000138	Acidosis		Ammonium Chloride	4.10	18287403
MESH:D000236	Adenoma		beta-Naphthoflavone	7.50	19389873
MESH:D000236	Adenoma		Diethylnitrosamine	7.50	10737359 6695378
MESH:D018248	Adenoma, Liver Cell		Diethylnitrosamine	4.44	18056438 19061943 16434500 19052882 17162532 17620307
MESH:D001145	Arrhythmias, Cardiac		Amiodarone	4.15	18057881 20041841 18218290
MESH:D001281	Atrial Fibrillation		Amiodarone	4.16	18651412 19698954
MESH:D001778	Blood Coagulation Disorders		Amiodarone	4.27	19483382
MESH:D001943	Breast Neoplasms		Diethylnitrosamine	2.19	17474063
MESH:D053840	Brugada Syndrome	marker/mechanism
MESH:D006528	Carcinoma, Hepatocellular		Diethylnitrosamine	1.87	19394651 20727157 20432363 18393292 10737359 16878318 20935162 18788625 18978308 19701751 20524982 10672840 18494052 16328049 16698587 19919837 20512989 19539802 16540662 16502159 17162532 20514400 19107877 19208518 19822196 17055752 17428255 3084413 19335982 17761372 19418558 18210153 20084675 16935385 19383236 20214788 18785209 19052882 16681979 16569478 18665156 18506893 18691550 11831363 20007298 17978847 18971187 19171122 16807293 17173139 3581430 16288022 16830150 16779866 21159647 17138121 20101231 19519916 18056438
MESH:D002311	Cardiomyopathy, Dilated		Amiodarone	2.99	15710769 19225199
MESH:D002341	Carotid Artery Thrombosis		Amiodarone	5.62	18974383
MESH:D002471	Cell Transformation, Neoplastic		Diethylnitrosamine	3.09	17174075 7505956 2727394 21159647
MESH:D018281	Cholangiocarcinoma		Diethylnitrosamine	4.01	19052882
MESH:D003924	Diabetes Mellitus, Type 2		Diethylnitrosamine	2.25	20387270
MESH:D056486	Drug-Induced Liver Injury		Amiodarone	4.32	15265979 18218290
MESH:D056486	Drug-Induced Liver Injury		Diethylnitrosamine	4.32	19107877
MESH:D004931	Esophageal Achalasia		Diethylnitrosamine	5.73	16302075
MESH:D005234	Fatty Liver		Amiodarone	9.22	14986274
MESH:D005234	Fatty Liver		Diethylnitrosamine	9.22	20387270 21071580
MESH:D006529	Hepatomegaly		Amiodarone	4.23	15265979
MESH:D006937	Hypercholesterolemia		Amiodarone	4.25	8137927 9751232
MESH:D007037	Hypothyroidism		Amiodarone	5.00	18020914 17991464
MESH:D007249	Inflammation		Diethylnitrosamine	2.53	18785209
MESH:D008064	Lipidoses		Amiodarone	3.76	17567588 15342952
MESH:D008103	Liver Cirrhosis		Diethylnitrosamine	2.99	19638242 18522880 18407596 20032147 18665156
MESH:D008107	Liver Diseases		Diethylnitrosamine	2.16	17034775
MESH:D008113	Liver Neoplasms		beta-Naphthoflavone	5.14	19389873 21295105
MESH:D008113	Liver Neoplasms		Diethylnitrosamine	5.14	19690152 20501860 18648771 19833225 20101389 20434301 19426721 20492335 19254457 15885732 15175105 20405173 19812893 21071580 18644402 19996281 19294768 19551842 18754104 9163691 18977376 20583210 20452335 21167192 19499222 16942905 20137499 21047994 12112319 2422723 19638242 18978307 21278145 19427195 12771043 19255062 19073162 20118626 19850985 19256749 10737359 2862719 19090486 19642983
MESH:D008114	Liver Neoplasms, Experimental		beta-Naphthoflavone	6.82	18164116
MESH:D008114	Liver Neoplasms, Experimental		Diethylnitrosamine	6.82	18093689 16267830 17174075 18079962 18253720 18544905 18308698 19539802 17854601 18775883 17942915 3124819 9362446 19519916 18282651 2563599 16842330 19009564 18164116 19126423 21159647 19004024
MESH:D008133	Long QT Syndrome		Amiodarone	3.85	11989578 15350150 17391786
MESH:D008171	Lung Diseases		Amiodarone	3.60	12587719
MESH:D017563	Lung Diseases, Interstitial		Amiodarone	5.09	18516814
MESH:D008175	Lung Neoplasms		Diethylnitrosamine	1.76	6695378 21163286 20970405 20512841
MESH:D009181	Mycoses		Amiodarone	5.51	12754197 17974566
MESH:D009362	Neoplasm Metastasis		Diethylnitrosamine	2.68	3581430 9029167
MESH:D019636	Neurodegenerative Diseases		Diethylnitrosamine	3.65	20387270
MESH:D009461	Neurologic Manifestations		Diethylnitrosamine	5.73	20387270
MESH:D010190	Pancreatic Neoplasms		Diethylnitrosamine	2.52	16540662
MESH:D011230	Precancerous Conditions		Diethylnitrosamine	3.88	2563599
MESH:D011658	Pulmonary Fibrosis		Amiodarone	2.96	12832656 12490602 11597910
OMIM:609620	SHORT QT SYNDROME 1		Amiodarone	5.62	18724381
OMIM:163800	SICK SINUS SYNDROME 2, AUTOSOMAL DOMINANT	marker/mechanism
MESH:D013274	Stomach Neoplasms		Diethylnitrosamine	1.76	18456281
MESH:D013276	Stomach Ulcer		Amiodarone	3.68	18087811
MESH:D013610	Tachycardia		Amiodarone	4.73	11238279
MESH:D017180	Tachycardia, Ventricular		Amiodarone	4.63	19225199
MESH:D013959	Thyroid Diseases		Amiodarone	5.37	19731979
MESH:D013964	Thyroid Neoplasms		Diethylnitrosamine	3.25	7505956
MESH:D013971	Thyrotoxicosis		Amiodarone	5.34	19584973 18020914
MESH:D016171	Torsades de Pointes		Amiodarone	4.73	11989578 17467628

Desease Name
Brugada syndrome 8
Sick sinus syndrome 2

AutismKB 2.0

Annotation Detail for HCN4

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics