AutismKB 2.0

Annotation Detail for CDH5


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Basic Information Top
Gene Symbol:CDH5 ( 7B4,CD144,FLJ17376 )
Gene Full Name: cadherin 5, type 2 (vascular endothelium)
Band: 16q21
Quick LinksEntrez ID:1003; OMIM: 601120; Uniprot ID:CADH5_HUMAN; ENSEMBL ID: ENSG00000179776; HGNC ID: 1764
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
Pathway IDPathway Name
200181S1P2 pathway
200161Signaling events mediated by VEGFR1 and VEGFR2
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased expression of CDH5 mRNAincreases expression 12540782
D000082 Acetaminophen O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of CDH5 mRNA]decreases reaction|increases expression 12540782
D004041 Dietary Fats Dietary Fats results in increased expression of CDH5 mRNAincreases expression 15238619
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of CDH5 mRNAaffects cotreatment|decreases expression 17404688
D005665 Furosemide Furosemide results in decreased expression of CDH5 mRNAdecreases expression 16526316
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate affects the expression of CDH5 mRNAaffects expression 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate [sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in increased expression of CDH5 mRNAaffects cotreatment|increases expression 19615344
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of CDH5 mRNAdecreases expression 15585362
C107010 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of CDH5 mRNA]decreases reaction|increases expression 12540782
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of CDH5 mRNAaffects cotreatment|decreases expression 17404688
C017947 sodium arsenite [sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in increased expression of CDH5 mRNAaffects cotreatment|increases expression 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of CDH5 mRNAdecreases expression 19615344
C017947 sodium arsenite sodium arsenite results in increased expression of CDH5 mRNAincreases expression 17879257
C025643 vinclozolin vinclozolin affects the expression of CDH5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1716712894 17306315
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15380490 15845082
MESH:D001943 Breast Neoplasms marker/mechanism 18507500
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Estradiol 1.9217018787 17289903 18497071 16675129 19861407 12948864 17261762 14630087
MESH:D001943 Breast Neoplasms Progesterone 1.9217614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.6716507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4218572023
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1318566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.1319524636 20056578
MESH:D015179 Colorectal Neoplasms marker/mechanism 18507500
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.5016227642 18713872 14725611 12705907 16781746 11743745 16109766 18071297 19416960 17906064 16081117 11739529 10915739 12540782 11834606 15619225 11287661 19923254 19739265 14550746 11461765 2444490 19085960 12958197 15968718 11421492 16177239 16393943 19164858 10774834 10663392 16485898 19370779 12594235 19420014 11529661 17522070 14986274 12153990 17562736 12392966
MESH:D056486 Drug-Induced Liver Injury O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate 4.5012540782
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004417 Dyspnea Furosemide 5.2116935035
MESH:D004487 Edema Furosemide 4.1711834646
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0919148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D005234 Fatty Liver Dietary Fats 3.4119004024 19551842 18296743 17967931
MESH:D005355 Fibrosis Dietary Fats 3.7418296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D034381 Hearing Loss Furosemide 4.9817868369
MESH:D006333 Heart Failure Furosemide 4.1616011733 16845234 12660669
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006934 Hypercalcemia Furosemide 5.2517652376
MESH:D053565 Hypercalciuria Furosemide 5.8917652376
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.1415086907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.5016612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.8911041285
MESH:D007019 Hypoproteinemia Furosemide 6.1416096441
MESH:D007022 Hypotension Furosemide 4.8011041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.6815811171
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007248 Infertility, Male sodium arsenite 7.2215346721 12646999
MESH:D007248 Infertility, Male vinclozolin 7.2216467254
MESH:D007249 Inflammation Dietary Fats 5.4620412841
MESH:D007249 Inflammation Progesterone 5.4615869954
MESH:D007333 Insulin Resistance Dietary Fats 7.7311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.7316393666 16627594
MESH:D007674 Kidney Diseases Acetaminophen 15.2615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 15.2615618244
MESH:D007674 Kidney Diseases Furosemide 15.2611041285
MESH:D007674 Kidney Diseases sodium arsenite 15.2620008137
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 12587719 19460945 11587558 16611625 19784758 12969438 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms sodium arsenite 2.4215276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 15276417 17077188 19931552 16712894
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4117203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4117203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009369 Neoplasms sodium arsenite 2.5711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009397 Nephrocalcinosis Furosemide 6.1415086907
MESH:D009421 Nervous System Malformations Estradiol 3.8511399458 16427766
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D053206 Nocturnal Enuresis Furosemide 6.1417945291
MESH:D009765 Obesity Dietary Fats 2.3221332399 20132043 18674790 17217161 16723640 11836018 18457598 20518802 19632207
MESH:D010051 Ovarian Neoplasms Estradiol 8.1819401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.1816525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.1817306315 15276417
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D011141 Polyuria Furosemide 5.8917945291
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1318042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1916740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1916039940
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D015427 Reperfusion Injury Furosemide 3.9816526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.8015912074 12394941 16096441
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012878 Skin Neoplasms sodium arsenite 2.7719524636 18572023
MESH:D013119 Spinal Cord Injuries Progesterone 4.5215862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5616712894 16452187 17306315 11723127
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:04670 Leukocyte transendothelial migration
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26301
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00480 antagonist Lenalidomide Antineoplastic Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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