AutismKB 2.0

Annotation Detail for CHAF1A


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Basic Information Top
Gene Symbol:CHAF1A ( CAF-1,CAF1,CAF1B,CAF1P150,MGC71229,P150 )
Gene Full Name: chromatin assembly factor 1, subunit A (p150)
Band: 19p13.3
Quick LinksEntrez ID:10036; OMIM: 601246; Uniprot ID:CAF1A_HUMAN; ENSEMBL ID: ENSG00000167670; HGNC ID: 1910
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in decreased expression of CHAF1A mRNAdecreases expression 17991464
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHAF1A mRNAdecreases expression 19150397
20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CHAF1A mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of CHAF1A mRNAdecreases expression 20106945
D019833 Genistein Genistein results in decreased expression of CHAF1A mRNAdecreases expression 16705744
C008493 methylselenic acid methylselenic acid results in decreased expression of CHAF1A mRNAdecreases expression 12517777
C006253 pirinixic acid pirinixic acid results in increased expression of CHAF1A mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of CHAF1A mRNA]increases expression|increases reaction 17950772
D011374 Progesterone Progesterone results in decreased expression of CHAF1A mRNAdecreases expression 16966611
C017947 sodium arsenite sodium arsenite results in increased expression of CHAF1A proteinincreases expression 19072884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2216712894 17306315
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9918218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.0518651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.7819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7819483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Genistein 2.3316873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 2.3317614352 15562024 16175315
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.2616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2617306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9515710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.4416332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.9819524636 20056578
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4415265979 18218290
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0217692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.8716402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4911473722
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver Amiodarone 14.3314986274
MESH:D005234 Fatty Liver Cyclosporine 14.3319224547
MESH:D005234 Fatty Liver pirinixic acid 14.3319236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Genistein 3.3816598420
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly Amiodarone 9.4515265979
MESH:D006529 Hepatomegaly pirinixic acid 9.4519176532 16221962 19772884 18467677
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006937 Hypercholesterolemia Amiodarone 4.089751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007037 Hypothyroidism Amiodarone 4.7718020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007248 Infertility, Male sodium arsenite 3.1215346721 12646999
MESH:D007249 Inflammation Progesterone 2.6915869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.388314463 18776723 10903974
MESH:D007674 Kidney Diseases sodium arsenite 6.3820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia Genistein 3.1117468513 18980019
MESH:D008064 Lipidoses Amiodarone 3.6515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4915474484
MESH:D008113 Liver Neoplasms pirinixic acid 4.7120007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 4.7116712894 15276417
MESH:D008133 Long QT Syndrome Amiodarone 3.7311989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 7.9612587719
MESH:D008171 Lung Diseases sodium arsenite 7.9619095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms sodium arsenite 1.8916712894 19931552 17306315 17077188 15276417
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.6217203775 11408345
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009181 Mycoses Amiodarone 5.2217974566 12754197
MESH:D009203 Myocardial Infarction Genistein 5.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.9319151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9216411023
MESH:D009369 Neoplasms pirinixic acid 5.2517405874
MESH:D009369 Neoplasms sodium arsenite 5.2511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Genistein 4.2716427766
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010024 Osteoporosis Genistein 3.3719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3116169203
MESH:D010051 Ovarian Neoplasms Genistein 8.2819005980
MESH:D010051 Ovarian Neoplasms Progesterone 8.2816525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.2817306315 15276417
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Genistein 2.6616925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6616205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6616039940
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9212832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D012878 Skin Neoplasms sodium arsenite 6.1219524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.128532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D013959 Thyroid Diseases Amiodarone 5.0819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.4717467628 11989578
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5716712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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