AutismKB 2.0

Annotation Detail for CDH6


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Basic Information Top
Gene Symbol:CDH6 ( KCAD )
Gene Full Name: cadherin 6, type 2, K-cadherin (fetal kidney)
Band: 5p13.3
Quick LinksEntrez ID:1004; OMIM: 603007; Uniprot ID:CADH6_HUMAN; ENSEMBL ID: ENSG00000113361; HGNC ID: 1765
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell junction organization
No data
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019386 Alendronate Alendronate affects the expression of CDH6 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDH6 mRNAaffects expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of CDH6 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of CDH6 mRNAaffects cotreatment|increases expression 18585445
C006780 bisphenol A bisphenol A affects the expression of CDH6 mRNAaffects expression 20170705
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of CDH6 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDH6 mRNAaffects expression 16079270
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDH6 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDH6 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of CDH6 mRNAaffects cotreatment|decreases expression 17404688
D020849 Raloxifene Raloxifene affects the expression of CDH6 mRNAaffects expression 16079270
D014212 Tretinoin Tretinoin results in increased expression of CDH6 mRNAincreases expression 16236135
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4211874814
MESH:D000419 Albuminuria Raloxifene 4.7617308373 17451421
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4516197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 11.5615665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 11.5616580743
MESH:D001943 Breast Neoplasms bisphenol A 2.3917123778
MESH:D001943 Breast Neoplasms Estradiol 2.3917261762 17289903 19861407 16675129 12948864 14630087 17018787 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.3917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 2.3917242785 15758505 15775269 15572757 17261762 17893378 17952589 17049068 17595753 17440819 16837676 16912660
MESH:D001943 Breast Neoplasms Tretinoin 2.3916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.061917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0917110522 17681005 15861022 16105132 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8214991402 16925845 9125849 8800419 17551590 9211117 9664655 9224671 10589399 9142499
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003928 Diabetic Nephropathies Estradiol 9.4319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.4315920148 17308373 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D004487 Edema pirinixic acid 7.3612083418
MESH:D004487 Edema Raloxifene 7.3615860553
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.3612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.3617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.3615845917
MESH:D016889 Endometrial Neoplasms Estradiol 7.7118566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7116569247
MESH:D004715 Endometriosis Progesterone 3.9016134523
MESH:D005124 Eye Abnormalities Tretinoin 3.6816938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9415345470
MESH:D005234 Fatty Liver pirinixic acid 13.9420131406 19236843
MESH:D005234 Fatty Liver Raloxifene 13.9417473493
MESH:D005355 Fibrosis Tretinoin 3.6917994277
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.969664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 18467677 19176532 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006930 Hyperalgesia Alendronate 8.7416769263
MESH:D006930 Hyperalgesia Tretinoin 8.7416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Raloxifene 2.9117577099 15787275
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Atrazine 7.2112948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2117937319
MESH:D007249 Inflammation Progesterone 2.6615869954
MESH:D007333 Insulin Resistance bisphenol A 12.8316393666
MESH:D007333 Insulin Resistance Estradiol 12.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.8316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2417217047 17368321 19225113 16766008 16140955 17107899 19029980 19075265 17506722 16331271 12679006 19035177 17361223 17712046 17649720 17339181 16935935 15748426 17301526 9834237 16891316 19642359 16823087 17294898 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5316248980 18397230
MESH:D008113 Liver Neoplasms pirinixic acid 1.8616377806 20007298 15890375
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3517203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.3511408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Atrazine 3.571916698
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6116411023
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009369 Neoplasms pirinixic acid 5.1217405874
MESH:D009369 Neoplasms Tretinoin 5.1216946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations bisphenol A 17.4116427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 17.4116427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 17.419125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Alendronate 8.0617882678
MESH:D010024 Osteoporosis Raloxifene 8.0617882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3817823083 15758505 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Estradiol 8.1219401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.1217393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 8.1216936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010300 Parkinson Disease Atrazine 3.3217218051
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.0220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.0220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6016740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6015731164 16536755 16220300
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012135 Respiratory Sounds Atrazine 4.6911874814
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012878 Skin Neoplasms Tretinoin 2.6716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 14.4519048282
MESH:D013978 Tibial Fractures Raloxifene 14.4519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8617572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
REACT:20676 Cell junction organization
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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