AutismKB 2.0

Annotation Detail for ABCC5


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Basic Information Top
Gene Symbol:ABCC5 ( ABC33,DKFZp686C1782,EST277145,MOAT-C,MOATC,MRP5,SMRP,pABC11 )
Gene Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Band: 3q27.1
Quick LinksEntrez ID:10057; OMIM: 605251; Uniprot ID:MRP5_HUMAN; ENSEMBL ID: ENSG00000114770; HGNC ID: 56
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluoresceinincreases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C043829 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC5 mRNAaffects binding|increases expression 15833929
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABCC5 mRNAincreases expression 15833929
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ABCC5 mRNAdecreases expression 16260000
D000082 Acetaminophen Acetaminophen results in increased expression of ABCC5 proteinincreases expression 17627974
D000082 Acetaminophen Acetaminophen affects the expression of ABCC5 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABCC5 mRNAaffects expression 16483693
D000927 Anticonvulsants ABCC5 protein results in decreased susceptibility to Anticonvulsantsdecreases response to substance 15581025
C006632 arsenic trioxide arsenic trioxide results in increased expression of ABCC5 mRNAincreases expression 20458559
D019324 beta-Naphthoflavone [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC5 mRNAaffects binding|increases expression 15833929
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of ABCC5 mRNAincreases expression 15833929
D002083 Butylated Hydroxyanisole [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNAincreases activity|increases expression 15833929
D002083 Butylated Hydroxyanisole Butylated Hydroxyanisole results in increased expression of ABCC5 mRNAincreases expression 15833929
C105934 celecoxib celecoxib results in increased expression of ABCC5 mRNAincreases expression 18690847
C105934 celecoxib celecoxib results in increased expression of ABCC5 proteinincreases expression 18690847
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCC5 mRNAaffects cotreatment|affects expression 17602206
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of ABCC5 mRNAincreases expression 17654400
D003513 Cycloheximide [Cycloheximide co-treated with Estradiol] results in decreased expression of ABCC5 mRNAaffects cotreatment|decreases expression 15072547
D003513 Cycloheximide Cycloheximide results in decreased expression of ABCC5 mRNAdecreases expression 15072547
C004742 daidzein daidzein inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
C004742 daidzein daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C014347 decitabine decitabine results in increased expression of ABCC5 mRNAincreases expression 19151715
D002945 Cisplatin ABCC5 mRNA results in decreased susceptibility to Cisplatindecreases response to substance 15882455
D002945 Cisplatin ABCC5 protein results in decreased susceptibility to Cisplatindecreases response to substance 17982673
C121718 dicyclanil dicyclanil results in increased expression of ABCC5 mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in increased expression of ABCC5 mRNAincreases expression 17640958
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCC5 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol [Cycloheximide co-treated with Estradiol] results in decreased expression of ABCC5 mRNAaffects cotreatment|decreases expression 15072547
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC5 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of ABCC5 mRNAdecreases expression 15072547
D004958 Estradiol Estradiol results in increased expression of ABCC5 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ABCC5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCC5 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ABCC5 mRNAdecreases expression 17557909
D005015 Ethoxyquin [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNAincreases activity|increases expression 15833929
D005015 Ethoxyquin Ethoxyquin results in increased expression of ABCC5 mRNAincreases expression 15833929
D005472 Fluorouracil ABCC5 protein results in decreased susceptibility to Fluorouracildecreases response to substance 19077464
C070081 fulvestrant fulvestrant results in decreased expression of ABCC5 mRNAdecreases expression 15072547
D005978 Glutathione ABCC5 protein affects the export of Glutathioneaffects export 15845416
C013015 hesperetin hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
C013015 hesperetin hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of ABCC5 mRNAincreases expression 15072547
C005273 naringenin naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
C005273 naringenin naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ABCC5 mRNAincreases expression 17616710
C026209 oltipraz [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNAincreases activity|increases expression 15833929
C026209 oltipraz oltipraz results in increased expression of ABCC5 mRNAincreases expression 15833929
D053683 Oncostatin M Oncostatin M results in increased expression of ABCC5 mRNAincreases expression 15654950
D010634 Phenobarbital Phenobarbital results in decreased expression of ABCC5 mRNAdecreases expression 16260000
D010862 Pilocarpine Pilocarpine affects the expression of ABCC5 mRNAaffects expression 19055492
C025299 polyphenols polyphenols results in increased expression of ABCC5 mRNAincreases expression 16293270
D011794 Quercetin ABCC5 protein results in decreased susceptibility to Quercetindecreases response to substance 16156793
D011794 Quercetin Quercetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
D011794 Quercetin Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
C059514 resveratrol ABCC5 protein results in decreased susceptibility to resveratroldecreases response to substance 16156793
C059514 resveratrol resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
D012838 Silymarin Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
D013024 Soybean Oil Soybean Oil affects the expression of ABCC5 mRNAaffects expression 15770074
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC5 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ABCC5 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ABCC5 mRNAaffects binding|increases expression 15833929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCC5 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ABCC5 mRNAincreases expression 15833929
D013866 Thioguanine daidzein inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
D013866 Thioguanine hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
D013866 Thioguanine naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
D013866 Thioguanine Quercetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]decreases reaction|decreases response to substance 16156793
C059141 verlukast verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]decreases reaction|increases export 16156793
D015215 Zidovudine ABCC5 protein results in increased export of Zidovudineincreases export 18535159
D015215 Zidovudine Zidovudine results in increased expression of ABCC5 mRNAincreases expression 15456083
D015215 Zidovudine ABCC5 protein results in increased export of Zidovudineincreases export 15456083
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Anticonvulsants 11.991168322
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.996195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.9915322242 14514962 11752688
MESH:D000015 Abnormalities, Multiple Anticonvulsants 5.631168322
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.409612607
MESH:D058186 Acute Kidney Injury Cisplatin 7.6115814532 12690470 17670903
MESH:D058186 Acute Kidney Injury resveratrol 7.6116538975
MESH:D055371 Acute Lung Injury verlukast 5.1217118201
MESH:D000230 Adenocarcinoma arsenic trioxide 15.4719825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 15.4711798837 17638652
MESH:D000230 Adenocarcinoma daidzein 15.4711473722
MESH:D000230 Adenocarcinoma Estradiol 15.4711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.4714692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.4717638652
MESH:D000236 Adenoma beta-Naphthoflavone 9.7919389873
MESH:D000236 Adenoma Diethylnitrosamine 9.796695378 10737359
MESH:D000236 Adenoma resveratrol 9.7915688382
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 28.1316628245
MESH:D018248 Adenoma, Liver Cell dicyclanil 28.1317162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 28.1317620307 19061943 17162532 19052882 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 28.1317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 28.1316835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.7119003578 16215675
MESH:D000544 Alzheimer Disease resveratrol 2.4716183991 16162502
MESH:D000740 Anemia Fluorouracil 7.4415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4411748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8517084956
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D001161 Arteriosclerosis Dietary Fats 8.5115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4515885639
MESH:D001169 Arthritis, Experimental resveratrol 6.4517115116
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5515336622
MESH:D050197 Atherosclerosis resveratrol 3.0117967414 16873680
MESH:D001284 Atrophy fulvestrant 4.4411514358
MESH:D001321 Autistic Disorder Acetaminophen 2.4318445737
MESH:D001321 Autistic Disorder Anticonvulsants 2.4317630868 16108456
MESH:D001321 Autistic Disorder Glutathione 2.4319267885 16917939 18929414 19056591
MESH:D001327 Autoimmune Diseases Quercetin 3.9919761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.6816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4514601052
MESH:D002545 Brain Ischemia resveratrol 3.8517600658
MESH:D001943 Breast Neoplasms Cisplatin 6.4418382427 19526202
MESH:D001943 Breast Neoplasms decitabine 6.4419208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 6.4420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.4417474063
MESH:D001943 Breast Neoplasms Estradiol 6.4419861407 12948864 17018787 16675129 17289903 17261762 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 6.4416110121 18357371 16595493 18608205 19217205 16557594 15136595
MESH:D001943 Breast Neoplasms fulvestrant 6.4418984771
MESH:D001943 Breast Neoplasms Quercetin 6.4418628248
MESH:D001943 Breast Neoplasms resveratrol 6.4417651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.4420435547
MESH:D016535 Bronchial Hyperreactivity verlukast 4.9812654629
MESH:D001986 Bronchial Spasm verlukast 5.7611432448
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9311589617
MESH:D002105 Cadmium Poisoning Quercetin 5.1116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0316111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2316051944
MESH:D002277 Carcinoma Fluorouracil 7.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 24.133084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 24.1315553829 16217749 11135700 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 24.1317982673
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 24.1317162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 24.1318971187 18393292 16698587 3084413 18978308 19052882 16779866 10672840 11831363 3581430 21159647 20084675 20512989 17761372 19822196 19539802 19383236 16288022 19107877 17978847 19418558 16807293 16830150 18785209 20101231 19335982 10737359 17428255 18665156 17138121 17162532 19701751 20524982 17173139 20007298 19171122 18494052 19394651 16540662 20514400 16681979 18506893 17055752 18210153 20432363 20935162 16328049 19519916 16569478 16878318 19208518 18056438 20727157 16502159 16935385 19919837 20214788 18788625 18691550
MESH:D006528 Carcinoma, Hepatocellular Estradiol 24.1316924424
MESH:D006528 Carcinoma, Hepatocellular Ethoxyquin 24.133084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 24.1316799960 17045692 18930000 16332177 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 24.131701930 6705139 20007298 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 24.1312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 24.1316227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1616675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8812023789 16685392
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5317234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4319014326
MESH:D002292 Carcinoma, Renal Cell celecoxib 6.3416369983
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3418695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7412490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 12.846189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 12.8419215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.8416280240 18986760 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Glutathione 12.8417015178
MESH:D002294 Carcinoma, Squamous Cell resveratrol 12.8416227395
MESH:D006332 Cardiomegaly Quercetin 5.9819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9818670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases daidzein 6.8616332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.8615458977
MESH:D002386 Cataract Acetaminophen 2.3210977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.7021159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.7018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.834080065
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 14.1316628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.1316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5616919318 17110522 17681005 15861022 11677210 17333356 16105132
MESH:D002971 Cleft Lip Anticonvulsants 5.011168322
MESH:D002972 Cleft Palate Anticonvulsants 5.911168322
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9116354765 15340226 8697196 15668235 12621046
MESH:D003092 Colitis resveratrol 3.7116474422
MESH:D003110 Colonic Neoplasms celecoxib 12.8316004971
MESH:D003110 Colonic Neoplasms decitabine 12.8317616700
MESH:D003110 Colonic Neoplasms Fluorouracil 12.8316340194 18772588 17016597 15001691 17169374 17725105 17287894 16510598 17172411 17018589
MESH:D003110 Colonic Neoplasms polyphenols 12.8316293270
MESH:D003110 Colonic Neoplasms Quercetin 12.8317191121 11134977 19056647 16640504 19440933 17148506 15741050
MESH:D003110 Colonic Neoplasms resveratrol 12.8316338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 9.6920501625
MESH:D015179 Colorectal Neoplasms celecoxib 9.6918349538 11197048
MESH:D015179 Colorectal Neoplasms Cisplatin 9.6915273666
MESH:D015179 Colorectal Neoplasms decitabine 9.6918981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.6918383874 16282729 17401013 20501625 17016601 16391804 16303861 18802399 15148649 17695437 18949393 16524972 17594712 18448328 15289873 17255274 18509181 14970324 16331619 18288408 17454858 17094418
MESH:D015179 Colorectal Neoplasms Quercetin 9.6918852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 9.6916550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7014669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.4716507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7812609071
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 3.6217686920
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6210048152 20055451 15322242
MESH:D003550 Cystic Fibrosis Glutathione 4.1219747007
MESH:D007644 Darier Disease Fluorouracil 4.3616733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7015213294
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.3919496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.3916873680
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.5116647724
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5117107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.8219279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.8216286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.3714550746 14986274 10663392 18071297 12540782 11461765 16781746 16227642 14725611 11834606 12153990 17906064 19739265 19416960 11529661 10915739 16081117 11421492 18713872 17522070 12594235 12958197 16177239 12705907 19370779 11287661 15619225 16393943 19923254 15968718 10774834 16109766 2444490 19085960 19420014 11743745 16485898 17562736 12392966 11739529 19164858
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 13.3717654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.3719107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 13.3719370779
MESH:D056486 Drug-Induced Liver Injury Silymarin 13.3714998559
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.3720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Cisplatin 11.9612649298 12231392 19839026 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 11.9611462148
MESH:D004362 Drug Toxicity Zidovudine 11.9615040536
MESH:D050171 Dyslipidemias Dietary Fats 3.1418367378
MESH:D004421 Dystonia Phenobarbital 3.611851702
MESH:D004487 Edema resveratrol 9.568985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5612711302 11000095
MESH:D004487 Edema verlukast 9.5617118201
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 10.9517686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.7717872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6819294695
MESH:D016889 Endometrial Neoplasms daidzein 6.9011473722
MESH:D016889 Endometrial Neoplasms Estradiol 6.9011473722 18566989 19148513
MESH:D004715 Endometriosis celecoxib 8.1315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.139294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4317923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.693659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.433922381 11558140
MESH:D004827 Epilepsy Phenobarbital 6.5220417680
MESH:D004827 Epilepsy Pilocarpine 6.5219439326 19700373 11162239
MESH:D004832 Epilepsy, Absence Phenobarbital 3.186401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.593659116
MESH:D007172 Erectile Dysfunction daidzein 4.6114972507
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6816302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.3912903497
MESH:D004938 Esophageal Neoplasms Cisplatin 9.3917638652 15173087 16481741 15464296 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.3915173087 17638652 16481741 16785472 16337965
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.3915264214 15547733 16510608 15878914 15623463 15150132 16704527 15547721 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6911564622
MESH:D005234 Fatty Liver arsenic trioxide 20.5915073043
MESH:D005234 Fatty Liver Dietary Fats 20.5919004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 20.5920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5915345470
MESH:D005234 Fatty Liver Zidovudine 20.5918299183
MESH:D005313 Fetal Death Anticonvulsants 9.741168322
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.7411858732
MESH:D005355 Fibrosis Dietary Fats 12.3918296743
MESH:D005355 Fibrosis Quercetin 12.3919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.3920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8516904648
MESH:D005756 Gastritis Acetaminophen 3.2416983495
MESH:D005909 Glioblastoma Quercetin 3.1119804834
MESH:D005910 Glioma Fluorouracil 5.5716145905
MESH:D005910 Glioma Quercetin 5.5717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 11.3315102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 11.3319215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.3318337622 15162350 15102660
MESH:D034381 Hearing Loss Cisplatin 3.9319898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0715464296
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 6.2217686920 20471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2211294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.3212579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006529 Hepatomegaly Phenobarbital 7.0516109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.5915709030
MESH:D006561 Herpes Simplex resveratrol 3.7516876885
MESH:D015658 HIV Infections Zidovudine 3.2611363243 11141242 11698656 17358032 20032539
MESH:D006689 Hodgkin Disease Cisplatin 3.2416200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.3217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6116354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.3716870215
MESH:D006937 Hypercholesterolemia Dietary Fats 7.9421332399
MESH:D006937 Hypercholesterolemia resveratrol 7.9417188708
MESH:D006943 Hyperglycemia Quercetin 3.6611834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 7.9721332399
MESH:D006949 Hyperlipidemias resveratrol 7.9716873680
MESH:D006973 Hypertension daidzein 7.7417169123
MESH:D006973 Hypertension Quercetin 7.7418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.7418850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2317600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0712013081
MESH:D007248 Infertility, Male decitabine 9.6417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.6417937319
MESH:D007248 Infertility, Male fulvestrant 9.6411514358
MESH:D007249 Inflammation Dietary Fats 20.6320412841
MESH:D007249 Inflammation Diethylnitrosamine 20.6318785209
MESH:D007249 Inflammation polyphenols 20.6316366677
MESH:D007249 Inflammation resveratrol 20.6316366677
MESH:D007249 Inflammation Silymarin 20.6317213517
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.6312200463 12878042
MESH:D007249 Inflammation verlukast 20.6317118201
MESH:D007251 Influenza, Human Quercetin 9.7316624496
MESH:D007251 Influenza, Human resveratrol 9.7316624496
MESH:D007333 Insulin Resistance Dietary Fats 6.4218457598 11836018
MESH:D007333 Insulin Resistance Estradiol 6.4216627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9516580747
MESH:D007627 Keloid Quercetin 4.5317086741
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7015464296
MESH:D007674 Kidney Diseases Acetaminophen 12.3512587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 12.3518289764 12231392 19839026 15190930 12649298
MESH:D007674 Kidney Diseases Estradiol 12.3515618244
MESH:D007674 Kidney Diseases Quercetin 12.3516962696
MESH:D007680 Kidney Neoplasms Estradiol 10.5315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 10.5316985049
MESH:D007680 Kidney Neoplasms Zidovudine 10.5312579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3611231351
MESH:D007938 Leukemia arsenic trioxide 9.2415070760
MESH:D007938 Leukemia decitabine 9.2418980019 19235587
MESH:D007938 Leukemia Quercetin 9.2417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.5612560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.5620370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.3119077051
MESH:D007951 Leukemia, Myeloid decitabine 8.3118454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6816968895 20471514 19850784 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.6817679729 18704418 19010910 19387464 18460780 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0218055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.8319642359 16891316 19035177 16966277 11468182 19225113 16823087 11161223 16112521 15622746 17649720 17869043 17107899 19075265 12712474 15213294 12679006 15748426 12018890 9834237 17712046 15336539 17217047 16330433 16331271
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.8316087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9416882451
MESH:D008103 Liver Cirrhosis Dietary Fats 13.8118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.8118665156 18522880 20032147 18407596 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 13.8121047994
MESH:D008103 Liver Cirrhosis Silymarin 13.8117213517
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.9214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental naringenin 7.9214709902
MESH:D008106 Liver Cirrhosis, Experimental oltipraz 7.9216544323
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 7.9212741479
MESH:D008106 Liver Cirrhosis, Experimental Silymarin 7.9215754394 17198567 15864749 18277467
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.9212878042
MESH:D008107 Liver Diseases Acetaminophen 14.2012587719 16611625 19460945 16610002 11587558 12969438 19784758 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 14.2017034775
MESH:D008107 Liver Diseases naringenin 14.2016945181
MESH:D008107 Liver Diseases Phenobarbital 14.2019363144
MESH:D008107 Liver Diseases polyphenols 14.2016698588
MESH:D008107 Liver Diseases Silymarin 14.2017213517
MESH:D008108 Liver Diseases, Alcoholic Silymarin 5.5017213517
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8617185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 34.5414682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 34.5421295105 19389873
MESH:D008113 Liver Neoplasms Clofibric Acid 34.5417602206
MESH:D008113 Liver Neoplasms dicyclanil 34.5420118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 34.5420137499 19073162 18754104 2422723 10737359 20583210 20492335 21167192 9163691 19551842 19426721 19996281 20452335 19850985 19833225 20434301 21278145 19255062 20405173 16942905 19256749 15885732 19499222 19427195 18644402 19090486 12771043 18978307 12112319 15175105 21047994 20118626 19638242 18648771 19690152 20501860 19812893 20101389 19254457 19642983 19294768 21071580 2862719 18977376
MESH:D008113 Liver Neoplasms Fluorouracil 34.5415113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 34.548742319 19812893 21047994 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms Quercetin 34.5418980244
MESH:D008113 Liver Neoplasms resveratrol 34.5419812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms Silymarin 34.5419168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 34.5416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.7920377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.7918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.799362446 17942915 19009564 18775883 19539802 18079962 16267830 18544905 19519916 18093689 19004024 3124819 17174075 18164116 18308698 18282651 2563599 21159647 17854601 19126423 16842330 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.796150874 1399818 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Quercetin 19.7919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 9.7011798837 19825857
MESH:D008175 Lung Neoplasms Cisplatin 9.706189445 17225452 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.7020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 9.7015246190
MESH:D008175 Lung Neoplasms Quercetin 9.7016280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.7011884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 9.7018800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3615086387
MESH:D008223 Lymphoma decitabine 3.1119470736
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5214749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8215688416
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 8.5612104042 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.5611807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.5611606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.0419453300
MESH:D008545 Melanoma Cisplatin 4.7317023156 16809738 12883367 16248763 11135225 15577323 17761969 16432458 18332650 18176117 12374674 18505091 12393984
MESH:D008545 Melanoma decitabine 4.7316505122 17785578
MESH:D008545 Melanoma resveratrol 4.7317992120
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008654 Mesothelioma Cisplatin 3.0617638057
MESH:D008659 Metabolic Diseases resveratrol 3.9917112576
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4017358032
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3016757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 14.8019417148 15949261 14977855 11468182 19549372
MESH:D009101 Multiple Myeloma celecoxib 14.8016123214
MESH:D009101 Multiple Myeloma decitabine 14.8018172295
MESH:D009101 Multiple Myeloma resveratrol 14.8017935668 16490592 14749477 17164350 17049120 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4417962980
MESH:D009139 Musculoskeletal Abnormalities Anticonvulsants 5.731168322
MESH:D009145 Mushroom Poisoning Silymarin 6.5017213517
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.6516105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 6.6516882708 18608210 19157545 19010910
MESH:D009203 Myocardial Infarction Quercetin 5.4119595682
MESH:D009203 Myocardial Infarction resveratrol 5.4116317513 16525036 16456233 17188708 17015251 17125593
MESH:D017202 Myocardial Ischemia resveratrol 7.8817015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4616810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.4619207477
MESH:D009205 Myocarditis resveratrol 4.3317322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0417484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5516624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.393581430 9029167
MESH:D009369 Neoplasms Cisplatin 13.3816773208
MESH:D009369 Neoplasms decitabine 13.3817925555 19116145 19470736
MESH:D009369 Neoplasms Fluorouracil 13.3818600527 18239605 16928823
MESH:D009369 Neoplasms naringenin 13.3815185748
MESH:D009369 Neoplasms Quercetin 13.3815185748
MESH:D009374 Neoplasms, Experimental resveratrol 3.588985016
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 4.9919196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3017289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0615464296
MESH:D009421 Nervous System Malformations Estradiol 14.2116427766 11399458
MESH:D009421 Nervous System Malformations Pilocarpine 14.2115987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2114600291
MESH:D009436 Neural Tube Defects Anticonvulsants 7.141168322
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1410525206
MESH:D009447 Neuroblastoma Cisplatin 3.228761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.0318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.0320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 12.0317652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.278761367
MESH:D020078 Neurogenic Inflammation Quercetin 9.3717929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.3717929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6820387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1416436463
MESH:D009765 Obesity Dietary Fats 2.1718674790 16723640 21332399 18457598 19632207 11836018 17217161 20132043 20518802
MESH:D010018 Osteomalacia Phenobarbital 3.9317016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.8819495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.8817513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.3616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 13.3617225452 19769630 6897625 15464296
MESH:D010051 Ovarian Neoplasms decitabine 13.3619259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 13.3619401270
MESH:D010051 Ovarian Neoplasms Quercetin 13.3619005980
MESH:D010146 Pain Acetaminophen 2.0616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 22.2515580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 22.2519003803
MESH:D010190 Pancreatic Neoplasms decitabine 22.2519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 22.2516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 22.2519003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 22.2516965848
MESH:D010190 Pancreatic Neoplasms Quercetin 22.2516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.7619927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9015464296
MESH:D010997 Pleural Neoplasms Cisplatin 4.9017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.282563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.282563599
MESH:D011230 Precancerous Conditions Quercetin 13.2819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thioguanine 5.5921297632
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.1616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.1611222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.3117616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms celecoxib 1.8817908994 15570007
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Quercetin 1.8814715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817675339 16731767 17636462 15767336 17804756 17718901
MESH:D011537 Pruritus Ethinyl Estradiol 2.8916919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.0612752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6518286688 16160472 18722050 15538739
MESH:D051437 Renal Insufficiency Cisplatin 3.9915464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1416325855
MESH:D015427 Reperfusion Injury resveratrol 3.0517058453 17520802 16317513 16314181 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.0119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.9916646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 8.9914601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.1116862918
MESH:D012640 Seizures Phenobarbital 5.6616876388 11442880 3137016 4039156
MESH:D012640 Seizures Pilocarpine 5.667750514 19660546
MESH:D003294 Seizures, Febrile Phenobarbital 4.396407741
MESH:D012878 Skin Neoplasms resveratrol 5.008985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9015464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5016709447
MESH:D013226 Status Epilepticus Pilocarpine 5.8219055492 15987249 19430551 11259499 19570321 19951488 15857427
MESH:D013274 Stomach Neoplasms arsenic trioxide 13.9017007042
MESH:D013274 Stomach Neoplasms Butylated Hydroxyanisole 13.901399818 3581430
MESH:D013274 Stomach Neoplasms celecoxib 13.9015609394
MESH:D013274 Stomach Neoplasms Cisplatin 13.9017522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 13.9019037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 13.9018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 13.9019015929 16424979 17498489 17172411 16951190 19084572 18567086 15786421 18396642 17522103
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 13.9017575124 12958204
MESH:D013274 Stomach Neoplasms Zidovudine 13.9017696246
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1116321402
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8117997062
MESH:D013736 Testicular Neoplasms Cisplatin 4.2315464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.4219014326
MESH:D013964 Thyroid Neoplasms decitabine 14.4217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.427505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.421399818
MESH:D013978 Tibial Fractures Estradiol 4.2519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.7416280240
MESH:D014062 Tongue Neoplasms resveratrol 8.7416227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5315213294
MESH:D014202 Tremor Pilocarpine 5.3717594079
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.8812973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Butylated Hydroxyanisole 13.881399818
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 13.8815464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.8817616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 13.8816720314
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.8216803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.8216803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.8217473185
MESH:D014594 Uterine Neoplasms celecoxib 13.8418645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.8414692618
MESH:D014594 Uterine Neoplasms resveratrol 13.8417044934
MESH:D014604 Uveal Neoplasms decitabine 4.4717785578
MESH:D014625 Vaginal Neoplasms Cisplatin 9.8015577323
MESH:D014625 Vaginal Neoplasms Zidovudine 9.8012579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8817488730
MESH:D014839 Vomiting Cisplatin 4.2811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D015430 Weight Gain Dietary Fats 3.3816723640
Pathway ID Pathway Name
KEGG:02010 ABC transporters
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA395
    • Releated gene ID Related gene Name
    PA395ABCC5
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444370Heart Failure
    PA443265Adenocarcinoma
    PA443557Brain Neoplasms
    PA443756Colonic Neoplasms
    PA444840Lymphoma
    PA444903Melanoma
    PA445204Ovarian Neoplasms
    PA445425Prostatic Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443340Anemia
    PA443937Drug Toxicity
    PA444773Leukopenia
    PA445113Neutropenia
    PA445846Thrombocytopenia
    Releated drug ID Related drug Name
    PA128406956fluorouracil
    PA449383docetaxel
    PA449014cisplatin
    PA449748gemcitabine
    PA451346sildenafil
    PA450379mercaptopurine
    PA452628nucleosides and nucleotides excl. reverse transcriptase inhibitors
    PA451663thioguanine
    PA452604xenobiotics
    PA450085irinotecan
    PA449177cytarabine
    PA449905hydrocortisone
    PA450198leucovorin
    PA450428methotrexate
    PA449733ganciclovir
    PA451954zidovudine
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00143 substrate BSS Plus Dietary supplement;Micronutrient
    DB00203 inhibitor Sildenafil Vasodilator Agents;Phosphodiesterase Inhibitors
    DB00515 inducer Cisplatin Antineoplastic Agents;Radiation-Sensitizing Agents;Cross-Linking Reagents
    DB00718 substrate Adefovir Dipivoxil Antiviral Agents;Reverse Transcriptase Inhibitors
    DB00770 inhibitor Caverject Sterile Powder - Kit 23.2mcg/Vial Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00917 inhibitor Dinoprostone Oxytocics;Prostaglandins
    DB00975 inhibitor Dipyridamole Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors
    DB01032 inhibitor Probenecid Uricosuric Agents;Adjuvants, Pharmaceutic
    DB01033 substrate Mercaptopurine Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Purine analogues;Antimetabolites, Antineoplastic
    DB01045 inducer Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01076 substrate Caduet Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01138 inhibitor Sulfinpyrazone Uricosuric Agents
    DB02527 inhibitor Cyclic Adenosine Monophosphate
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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