AutismKB 2.0

Annotation Detail for ABCB6


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Basic Information Top
Gene Symbol:ABCB6 ( ABC,ABC14,EST45597,FLJ22414,MTABC3,PRP,umat )
Gene Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 6
Band: 2q35
Quick LinksEntrez ID:10058; OMIM: 605452; Uniprot ID:ABCB6_HUMAN; ENSEMBL ID: ENSG00000115657,ENSG00000198925; HGNC ID: 47
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ABCB6 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ABCB6 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ABCB6 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABCB6 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ABCB6 mRNAincreases expression 20106945
20064835
C028026 coproporphyrinogen III ABCB6 protein binds to and affects the transport of coproporphyrinogen IIIaffects binding|affects transport 17006453
D016572 Cyclosporine Cyclosporine results in increased expression of ABCB6 mRNAincreases expression 20106945
C071834 glycidamide glycidamide results in increased expression of ABCB6 mRNAincreases expression 17822822
D006418 Heme Heme results in increased expression of ABCB6 mRNAincreases expression 17006453
D006418 Heme Heme results in increased expression of ABCB6 proteinincreases expression 17006453
D006418 Heme Heme results in increased expression of ABCB6 mRNAincreases expression 17006453
D006418 Heme Heme results in increased expression of ABCB6 proteinincreases expression 17006453
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of ABCB6 mRNAdecreases expression 17616710
D010634 Phenobarbital Phenobarbital results in increased expression of ABCB6 mRNAincreases expression 12082028
C006253 pirinixic acid pirinixic acid results in increased expression of ABCB6 mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ABCB6 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ABCB6 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.696195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.753712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.756695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.0017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.0016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.0016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.597296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.593084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.5920935162 20007298 6705139 1701930 17173139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.757505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7512371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.7319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.7319486331
MESH:D002779 Cholestasis pirinixic acid 13.7319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 12621046 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.902524372 12868966 14531868 8970840 11906362 18759878 8156756 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.241440618 6679447 16192314 9328219 11289319 9653073 9022650 18648102 6482804 8291058 7440962 18289764 18692083
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2416081117 17562736 12705907 16485898 12958197 15968718 16781746 19370779 14725611 19420014 16227642 10774834 11421492 19164858 11834606 12594235 16109766 12392966 17522070 15619225 16177239 16393943 19416960 10915739 18071297 19923254 11461765 12153990 14986274 18713872 19085960 11743745 19739265 17906064 11287661 10663392 14550746 12540782 11529661 2444490 11739529
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.393581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3916530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.3915547721 15623463 16805852 15264214 16704527 16510608 15150132 15547733 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 7.8319224547
MESH:D005234 Fatty Liver pirinixic acid 7.8320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Phenobarbital 15.0116109766
MESH:D006529 Hepatomegaly pirinixic acid 15.0118467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007249 Inflammation Heme 5.7412649161
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.7412878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.506582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 3.9919460945 11587558 12969438 16611625 19014921 12587719 16610002 19784758
MESH:D008107 Liver Diseases Phenobarbital 3.9919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9120195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 10.9119812893 19482888 15975961 19073162 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 10.9120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.08598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.086150874 1399818 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2018520028 18569708 20869020 20464547 20135361 18816296 6695378 17053015 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2019555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5216965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.212563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9617292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012640 Seizures Phenobarbital 2.743137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5620155912 2093021
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5612958204 17575124
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.353712494 6582329 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.351399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.068074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0617053015
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014947 Wounds and Injuries Heme 5.3512649161
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:02010 ABC transporters
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24388
    • Releated gene ID Related gene Name
    PA24388ABCB6
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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