AutismKB 2.0

Annotation Detail for DNM1L


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DNM1L ( DLP1,DRP1,DVLP,DYMPLE,DYNIV-11,FLJ41912,HDYNIV,VPS1 )
Gene Full Name: dynamin 1-like
Band: 12p11.21
Quick LinksEntrez ID:10059; OMIM: 603850; Uniprot ID:DNM1L_HUMAN; ENSEMBL ID: ENSG00000087470; HGNC ID: 2973
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05100Bacterial invasion of epithelial cells
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Apoptosis
No data
No data
Pathway IDPathway Name
500269Apoptotic execution phase
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
2051Leukemia
No data
No data
Desease Name
Encephalopahty, lethal, due to defective mitochondrial peroxisomal fission
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DNM1L mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DNM1L mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DNM1L mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of DNM1L mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNM1L mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1L mRNAaffects cotreatment|increases expression 18164116
D003513 Cycloheximide Cycloheximide results in increased expression of DNM1L mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of DNM1L mRNAaffects cotreatment|increases expression 19684285
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1L mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DNM1L mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DNM1L mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNM1L mRNAaffects cotreatment|increases expression 17942748
D007657 Ketone Bodies Ketone Bodies results in increased expression of DNM1L mRNAincreases expression 16807920
D016559 Tacrolimus PINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein]affects reaction|increases phosphorylation 19492085
D013629 Tamoxifen Tamoxifen affects the expression of DNM1L mRNAaffects expression 17555576
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of DNM1L mRNAaffects expression 18976794
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of DNM1L mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DNM1L mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNM1L mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DNM1L mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.767525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7614514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.403712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.4019389873
MESH:D000236 Adenoma Diethylnitrosamine 11.4010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3316434500 19052882 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001927 Brain Diseases marker/mechanism
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8217474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.8219288272 16202921 19200415 20544844 21152245 18815881 19066611 17893378 17261762 19189210 19103187 19011961 18997820 19410462 20005174 16873071 20390343 19142967 17440819 21138602 19487384 19115204 18821012 17049068 18984771 15668708 18425577 15565566 20859285 18351453 20065188 11161223 17242785 19189212 19289846 19084267 16818667 19221464 16273361 18855134 18629630 19059307 19155303 20135344 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.967296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9621159647 20935162 19701751 18785209 20007298 16878318 11831363 19383236 19052882 18971187 19822196 20084675 19539802 20524982 3084413 18978308 16779866 16807293 18210153 19107877 16328049 19519916 16502159 16698587 18393292 20512989 19171122 17428255 20514400 18665156 17173139 19418558 16288022 18691550 17761372 16830150 10672840 19919837 17138121 17162532 19208518 19394651 17978847 18056438 16935385 20432363 20214788 20101231 16569478 18494052 20727157 10737359 17055752 18788625 18506893 3581430 16681979 19335982 16540662
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9616924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Tacrolimus 4.6517703430
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.406135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.407505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.402727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.9919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9915861022 16919318 11677210 17681005 17333356 16105132 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 15668235 8697196 12621046 16354765
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.3515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.3514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 2524372 18759878 11906362 8970840 14531868 8156756 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.4821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.4818692083 7440962 18289764 1440618 8291058 9653073 9022650 18648102 11289319 16192314 6482804 9328219 6679447
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.4821346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.4819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004381 Duodenal Ulcer Tacrolimus 5.2017202747
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0816202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.4220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4215345470
MESH:D005234 Fatty Liver Tamoxifen 13.4214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006086 Graft vs Host Disease Tacrolimus 5.9516376943
MESH:D006130 Growth Disorders Tacrolimus 4.9511041285
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 18606429 15340226 16354765 16959395
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:C537153 Hypomagnesemia primary Tacrolimus 6.2411041285
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007022 Hypotension Tacrolimus 5.1811041285
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Diethylnitrosamine 8.4318785209
MESH:D007249 Inflammation Tamoxifen 8.4319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4312878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.129022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Tacrolimus 4.3011041285
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.1416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.1416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.146582329
MESH:D007680 Kidney Neoplasms Tamoxifen 18.1418625569
MESH:D008064 Lipidoses Tamoxifen 3.1915342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8519638242 18665156 18407596 18522880 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.467678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.4621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.4620583210 21278145 21047994 20137499 2422723 12771043 20501860 20101389 20492335 20452335 9163691 18648771 19256749 15175105 21167192 19812893 21071580 19254457 18978307 12112319 20405173 19638242 20434301 19294768 19551842 19499222 10737359 18977376 19996281 18644402 19833225 19426721 19255062 18754104 19850985 19073162 20118626 19690152 19090486 16942905 2862719 19642983 19427195 15885732
MESH:D008113 Liver Neoplasms Tamoxifen 14.4616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.012876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.01598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.0118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.0118079962 19126423 18544905 19009564 18775883 18308698 19519916 17174075 17854601 16267830 2563599 19539802 18093689 18282651 21159647 9362446 19004024 3124819 18253720 18164116 17942915 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.0112151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4021163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Tamoxifen 3.4018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4011884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6614580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D028361 Mitochondrial Diseases marker/mechanism
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.637678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.583581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.583581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.1020387270
MESH:D019636 Neurodegenerative Diseases Tacrolimus 9.1015081597
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 22.0312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 22.0316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 22.034026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 22.0314694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8916709447
MESH:D013088 Spermatocele Tamoxifen 11.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.266587162 6582329 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.267505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.088074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.0817572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
KEGG:04666 Fc gamma R-mediated phagocytosis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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