AutismKB 2.0

Annotation Detail for ABCF2


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Basic Information Top
Gene Symbol:ABCF2 ( ABC28,DKFZp586K1823,EST133090,HUSSY18,M-ABC1 )
Gene Full Name: ATP-binding cassette, sub-family F (GCN20), member 2
Band: 7q36.1
Quick LinksEntrez ID:10061; OMIM: 612510; Uniprot ID:ABCF2_HUMAN; ENSEMBL ID: ENSG00000033050; HGNC ID: 71
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1965Clear cell carcinoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABCF2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ABCF2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ABCF2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ABCF2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABCF2 mRNAdecreases expression 20018196
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCF2 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCF2 mRNAaffects cotreatment|increases expression 17917374
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCF2 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ABCF2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ABCF2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCF2 mRNAaffects cotreatment|increases expression 17942748
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCF2 mRNAaffects cotreatment|increases expression 17917374
D013629 Tamoxifen Tamoxifen affects the expression of ABCF2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCF2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ABCF2 mRNAincreases expression 17942748
D014501 Uranium Uranium affects the expression of ABCF2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of ABCF2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.877525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8711752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma Diethylnitrosamine 2.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4516434500 19061943 17620307 19052882 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8217474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.8215668708 19289846 19189210 18351453 18629630 18821012 17893378 18984771 19155303 19059307 19115204 19244106 15565566 19142967 18815881 17049068 19221464 16202921 20135344 17242785 19189212 16818667 20544844 16273361 11161223 19066611 19200415 20065188 20390343 19487384 20859285 18855134 19011961 17440819 21138602 20005174 19084267 19103187 17261762 18425577 19410462 18997820 16873071 21152245 19288272
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.993084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9911831363 18788625 16779866 20214788 16698587 17055752 21159647 16328049 20512989 16935385 19383236 20432363 19107877 20727157 19822196 19919837 19418558 16569478 20084675 18691550 10737359 16681979 16830150 18056438 18665156 16878318 18978308 19208518 20101231 16502159 17162532 19519916 20524982 18506893 20007298 18393292 18494052 17173139 16540662 16807293 18971187 19701751 20514400 17428255 20935162 10672840 19335982 3581430 19052882 17978847 19171122 18785209 16288022 19394651 19539802 17761372 18210153 17138121 3084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.5714694615
MESH:D002386 Cataract Acetaminophen 7.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.516135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.5117174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 17110522 16105132 15861022 16919318 17333356 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 16354765 12621046 8697196 15340226
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.4315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.5821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5810915739 10663392 14986274 16781746 11834606 11529661 16227642 12540782 18071297 14550746 11461765 19739265 19416960 14725611 17906064 12153990 17522070 17562736 11421492 11739529 11287661 16177239 12705907 16485898 12958197 19164858 19085960 19923254 10774834 19420014 16393943 11743745 2444490 15619225 19370779 16109766 12594235 18713872 12392966 15968718 16081117
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1016202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.5815345470
MESH:D005234 Fatty Liver Tamoxifen 13.5819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Diethylnitrosamine 8.5018785209
MESH:D007249 Inflammation Tamoxifen 8.5019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5012200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.8116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.8116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 12.8118625569
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718665156 18522880 20032147 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008107 Liver Diseases Acetaminophen 3.9719014921 16611625 12969438 16610002 19784758 12587719 19460945 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.567678174
MESH:D008113 Liver Neoplasms Clofibric Acid 14.5617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.5620118626 20137499 19642983 20492335 20501860 20452335 2862719 19833225 18648771 12112319 20101389 21278145 21071580 19690152 19254457 20405173 18977376 12771043 15175105 18644402 19294768 9163691 18978307 21047994 19427195 19638242 19090486 10737359 2422723 19426721 19073162 19499222 20583210 19256749 19551842 19812893 21167192 18754104 19996281 19850985 19255062 20434301 15885732 16942905
MESH:D008113 Liver Neoplasms Tamoxifen 14.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.552876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5519004024 3124819 17174075 18093689 19539802 18775883 16267830 18079962 19519916 17942915 9362446 18544905 19009564 18308698 18282651 2563599 21159647 16842330 17854601 19126423 18164116 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 14.5518544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5512151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4120970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 3.4118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4119555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6714580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.839029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.6116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.6116049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.6114694615
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.468653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24406
    • Releated gene ID Related gene Name
    PA24406ABCF2
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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