AutismKB 2.0

Annotation Detail for NR1H3


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Basic Information Top
Gene Symbol:NR1H3 ( LXR-a,LXRA,RLD-1 )
Gene Full Name: nuclear receptor subfamily 1, group H, member 3
Band: 11p11.2
Quick LinksEntrez ID:10062; OMIM: 602423; Uniprot ID:NR1H3_HUMAN; ENSEMBL ID: ENSG00000025434; HGNC ID: 7966
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa03320PPAR signaling pathway
Pathway IDPathway Name
Gene Expression
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1856Obesity
1918Atherosclerosis
1978Cholestasis
2059Communicable disease
2070Cholelithiasis
Desease Name
HDL cholesterol
METABOLIC
Desease Name
HDL cholesterol
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 12932788
C003585 22-hydroxycholesterol [alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H3 proteinaffects cotreatment|affects localization 16888799
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in increased activity of NR1H3 proteinincreases activity 9603267
C028358 24,25-epoxycholesterol NR1H3 protein promotes the reaction [24,25-epoxycholesterol results in increased abundance of Lipids]increases abundance|increases reaction 20079722
C028358 24,25-epoxycholesterol 24,25-epoxycholesterol binds to and affects the activity of NR1H3 proteinaffects activity|affects binding 11290837
C044563 24-hydroxycholesterol 24-hydroxycholesterol binds to and affects the activity of NR1H3 proteinaffects activity|affects binding 11290837
C007997 25-hydroxycholesterol 25-hydroxycholesterol results in increased activity of NR1H3 proteinincreases activity 9603267
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NR1H3 mRNAaffects expression 21346803
C029435 3-hydroxy-5-cholestenoic acid 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]affects binding|affects reaction 11089551
C029435 3-hydroxy-5-cholestenoic acid 3-hydroxy-5-cholestenoic acid binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 11089551
C100324 4,4-dimethylcholesta-8,14,24-trienol 4,4-dimethylcholesta-8,14,24-trienol results in increased activity of NR1H3 proteinincreases activity 9603267
C046938 9,11-linoleic acid 9,11-linoleic acid results in increased expression of NR1H3 mRNAincreases expression 15778275
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NR1H3 proteinaffects expression 20106945
C103303 alitretinoin [alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H3 proteinaffects cotreatment|affects localization 16888799
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NR1H3 mRNAaffects expression 16483693
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one results in increased expression of NR1H3 mRNAincreases expression 19883121
C006632 arsenic trioxide arsenic trioxide results in decreased activity of NR1H3 proteindecreases activity 20339114
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NR1H3 mRNAdecreases expression 20064835
D001647 Bile Acids and Salts NR1H3 protein affects the chemical synthesis of Bile Acids and Saltsaffects chemical synthesis 15725701
C006780 bisphenol A bisphenol A results in increased expression of NR1H3 mRNAincreases expression 14967926
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA]decreases expression|decreases reaction 17070507
D002784 Cholesterol NR1H3 protein affects the metabolism of Cholesterolaffects metabolic processing 15725701
D002784 Cholesterol NR1H3 protein affects the transport of Cholesterolaffects transport 15725701
D002791 Cholesterol, Dietary [Cholesterol, Dietary co-treated with Cholic Acid] results in increased activity of NR1H3 proteinaffects cotreatment|increases activity 14684380
D002791 Cholesterol, Dietary Cholesterol, Dietary results in increased activity of NR1H3 proteinincreases activity 14684380
D019826 Cholic Acid [Cholesterol, Dietary co-treated with Cholic Acid] results in increased activity of NR1H3 proteinaffects cotreatment|increases activity 14684380
C019304 ciprofibrate ciprofibrate results in decreased expression of NR1H3 mRNAdecreases expression 12771043
C503589 cis-9, trans-11-conjugated linoleic acid cis-9, trans-11-conjugated linoleic acid affects the expression of NR1H3 mRNAaffects expression 17327424
D002994 Clofibrate Clofibrate results in increased expression of NR1H3 mRNAincreases expression 14690017
D002994 Clofibrate Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]decreases reaction|increases expression 14690017
D003474 Curcumin Curcumin results in increased expression of NR1H3 mRNAincreases expression 16713233
D003513 Cycloheximide Cycloheximide results in increased expression of NR1H3 mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NR1H3 mRNAaffects cotreatment|increases expression 19684285
D016572 Cyclosporine Cyclosporine results in decreased expression of NR1H3 mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of NR1H3 mRNAincreases expression 19022236
D004041 Dietary Fats Dietary Fats results in increased expression of NR1H3 mRNAincreases expression 18457598
17932310
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of NR1H3 mRNAdecreases expression 12771043
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NR1H3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR1H3 mRNAaffects cotreatment|increases expression 17942748
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated binds to and results in decreased activity of NR1H3 proteinaffects binding|decreases activity 12970175
D005419 Flavonoids Flavonoids results in increased expression of NR1H3 mRNAincreases expression 18035473
C504517 GSK 3987 GSK 3987 binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 16107141
C504517 GSK 3987 GSK 3987 binds to NR1H3 proteinaffects binding 16107141
C473027 GW 3965 GW 3965 binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 12932788
C473027 GW 3965 GW 3965 results in increased expression of NR1H3 mRNAincreases expression 17449538
C473027 GW 3965 GW 3965 binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 15633131
C473027 GW 3965 GW 3965 results in increased activity of NR1H3 proteinincreases activity 17420776
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NR1H3 mRNAaffects cotreatment|increases expression 17183730
C051140 iron(II)-ascorbic acid complex Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA]decreases expression|decreases reaction 17070507
C051140 iron(II)-ascorbic acid complex iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNAdecreases expression 17070507
D007654 Ketoconazole Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]decreases reaction|increases expression 14690017
D008055 Lipids NR1H3 protein promotes the reaction [24,25-epoxycholesterol results in increased abundance of Lipids]increases abundance|increases reaction 20079722
D008055 Lipids NR1H3 protein promotes the reaction [paxilline results in increased abundance of Lipids]increases abundance|increases reaction 20079722
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of NR1H3 mRNAdecreases expression 16847310
C048220 paxilline NR1H3 protein promotes the reaction [paxilline results in increased abundance of Lipids]increases abundance|increases reaction 20079722
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of NR1H3 mRNAdecreases expression 17681415
C059514 resveratrol resveratrol results in increased expression of NR1H3 mRNAincreases expression 16901463
C059514 resveratrol resveratrol results in increased expression of NR1H3 proteinincreases expression 16901463
C093642 SB 203580 SB 203580 results in increased expression of NR1H3 mRNAincreases expression 19883121
C017947 sodium arsenite sodium arsenite results in decreased expression of NR1H3 mRNAdecreases expression 19822182
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NR1H3 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NR1H3 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR1H3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NR1H3 mRNAincreases expression 18796159
C423915 TO-901317 TO-901317 binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 12932788
12970175
C423915 TO-901317 TO-901317 promotes the reaction [[NR1H3 protein binds to NR1H2 protein] which binds to SREBF1 promoter]affects binding|increases reaction 15548517
C423915 TO-901317 TO-901317 results in increased expression of NR1H3 mRNAincreases expression 17449538
C423915 TO-901317 TO-901317 binds to and results in increased activity of NR1H3 proteinaffects binding|increases activity 19509184
17088262
D014212 Tretinoin Tretinoin results in increased expression of NR1H3 mRNAincreases expression 16054129
C113580 U 0126 U 0126 inhibits the reaction [TNF protein results in decreased expression of NR1H3 mRNA]decreases expression|decreases reaction 19883121
C113580 U 0126 U 0126 results in increased expression of NR1H3 mRNAincreases expression 19883121
D014501 Uranium Uranium results in increased expression of NR1H3 mRNAincreases expression 16231126
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NR1H3 mRNAaffects cotreatment|increases expression 17183730
D015054 Zymosan Zymosan results in decreased expression of NR1H3 mRNAdecreases expression 16847310
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5411752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 6.548875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4519490988
MESH:D000138 Acidosis Ammonium Chloride 3.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3917505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.9517694057
MESH:D058186 Acute Kidney Injury resveratrol 3.3816538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.5411850527 18653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.0419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.0420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.0414692618
MESH:D000236 Adenoma Benzo(a)pyrene 9.276695378
MESH:D000236 Adenoma Diethylnitrosamine 9.276695378 10737359
MESH:D000236 Adenoma resveratrol 9.2715688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.2717162532 19061943 18056438 16434500 19052882 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.2716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3516712894 17306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5317887948
MESH:D000505 Alopecia Tretinoin 3.1815955085
MESH:D000544 Alzheimer Disease 24-hydroxycholesterol 8.3514523054
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 8.3520157255
MESH:D000544 Alzheimer Disease Curcumin 8.3515590663
MESH:D000544 Alzheimer Disease resveratrol 8.3516162502 16183991
MESH:D000550 Amblyopia Valproic Acid 4.6817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4411748828
MESH:D000740 Anemia Zymosan 7.4418664788
MESH:D001008 Anxiety Disorders Valproic Acid 3.1417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5519183758
MESH:D001161 Arteriosclerosis 9,11-linoleic acid 20.2115778275
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 20.2115552841
MESH:D001161 Arteriosclerosis Dietary Fats 20.2115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 20.2111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 19.3417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 19.3415885639
MESH:D001169 Arthritis, Experimental resveratrol 19.3417115116
MESH:D001169 Arthritis, Experimental Tretinoin 19.3416412693
MESH:D001169 Arthritis, Experimental Zymosan 19.3415188379 15142272 15944321 17659584 16872482
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.2116807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2116292516
MESH:D001249 Asthma Tretinoin 2.1616456186
MESH:D050197 Atherosclerosis Cholesterol 9.2716632123
MESH:D050197 Atherosclerosis Curcumin 9.2718704882
MESH:D050197 Atherosclerosis resveratrol 9.2716873680 17967414
MESH:D001321 Autistic Disorder Valproic Acid 2.0818940202 15238991 17157402 18558336 17507914 20603192 17688650 18177632 19460635 18775368 19232924 18985861 18396377 16609825 18316065
MESH:D001327 Autoimmune Diseases Curcumin 3.9719761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8916935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.7820046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 18.0516206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 18.0519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 18.0512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 18.0516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.8215746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.828888407
MESH:D001862 Bone Resorption bisphenol A 3.3811985600
MESH:D002545 Brain Ischemia Curcumin 8.5416770732
MESH:D002545 Brain Ischemia resveratrol 8.5417600658
MESH:D001932 Brain Neoplasms Curcumin 3.4717596214
MESH:D001943 Breast Neoplasms alitretinoin 5.1316344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.1320146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 5.1317123778
MESH:D001943 Breast Neoplasms Curcumin 5.1318593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Dietary Fats 5.1320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.1317474063
MESH:D001943 Breast Neoplasms resveratrol 5.1316393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.1320435547
MESH:D001943 Breast Neoplasms Tretinoin 5.1316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0516813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8311589617
MESH:D002277 Carcinoma Curcumin 6.8618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6116168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.9016705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 14.9012619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 14.9019418558
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 14.9016217749 15553829 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 14.9016569478 16328049 18056438 19519916 10737359 3581430 19383236 19701751 20524982 20514400 16779866 18506893 18494052 18393292 17055752 20727157 19208518 3084413 20007298 19394651 20432363 16878318 18971187 19919837 16830150 18788625 16540662 18785209 19822196 18210153 21159647 19335982 20101231 20084675 20512989 19052882 17162532 17173139 16935385 16288022 10672840 17761372 16681979 19539802 19418558 17978847 18978308 20935162 16698587 16502159 20214788 16807293 11831363 19171122 18665156 17138121 18691550 17428255 19107877
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.9016227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.9015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.901917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4517123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0516675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7718414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3319014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.3120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 12.3118462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 12.3116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.3118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.3116096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.1015458977
MESH:D002386 Cataract Tretinoin 2.7617460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.066135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.061399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.0612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.067505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.0619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0516129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4920734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.8119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.8116835633
MESH:D002779 Cholestasis Cyclosporine 6.4319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4315861022 16919318 17110522 17681005 11677210 16105132 17333356
MESH:D002822 Choriocarcinoma Tretinoin 4.6116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.9216354765 8697196 15340226 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 4.929407595
MESH:D003092 Colitis Curcumin 13.0716804969 18200517 16782535
MESH:D003092 Colitis resveratrol 13.0716474422
MESH:D003092 Colitis Tretinoin 13.0717035595
MESH:D003103 Coloboma Curcumin 4.0718809619
MESH:D003110 Colonic Neoplasms Curcumin 5.2019359593 16340194
MESH:D003110 Colonic Neoplasms Dexamethasone 5.2015824018
MESH:D003110 Colonic Neoplasms resveratrol 5.2016338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.4720501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.4716550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.3718497527
MESH:D003327 Coronary Disease resveratrol 3.3916507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.4710525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.4717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.4710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.479142499 16925845 14991402 10589399 9664655 9224671 9211117 17551590 8800419 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.478888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6015213294
MESH:D003715 Dengue 24-hydroxycholesterol 5.6719427377
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9112438553
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3316873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.1718403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.1717107852
MESH:D003928 Diabetic Nephropathies Curcumin 7.7318204486
MESH:D003928 Diabetic Nephropathies resveratrol 7.7316286809
MESH:D003967 Diarrhea Dexamethasone 3.207237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.9721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.9719107877
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 9.9718289764
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.9720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.971733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3611462148
MESH:D004381 Duodenal Ulcer Curcumin 3.5417351913
MESH:D050171 Dyslipidemias Clofibrate 7.5016707586
MESH:D050171 Dyslipidemias Dietary Fats 7.5018367378
MESH:D004421 Dystonia Valproic Acid 3.551851702
MESH:D004485 Eczema Dexamethasone 3.9512438553
MESH:D004487 Edema Dexamethasone 16.6419703484
MESH:D004487 Edema perfluorooctanoic acid 16.6417259670 12083418
MESH:D004487 Edema resveratrol 16.648985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.6412711302 11000095
MESH:D004487 Edema Zymosan 16.647907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.1215322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.1218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 24-hydroxycholesterol 12.7017410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.7012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 12.7017872969
MESH:D016889 Endometrial Neoplasms Tretinoin 2.7516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5610568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.8615821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3217923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.6317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.373922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.6420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.146254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.777750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.533659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5716302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 3.8812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.8816530937
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 6.0011346197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4811564622
MESH:D005124 Eye Abnormalities Tretinoin 7.4816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 34.9015073043
MESH:D005234 Fatty Liver Clofibrate 34.9019224547
MESH:D005234 Fatty Liver Curcumin 34.9019297423
MESH:D005234 Fatty Liver Cyclosporine 34.9019224547
MESH:D005234 Fatty Liver Dietary Fats 34.9017967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 34.9020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.9015345470
MESH:D005234 Fatty Liver Valproic Acid 34.9019224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.628888407 18558336
MESH:D005334 Fever Lipopolysaccharides 3.559205823 11852909
MESH:D005355 Fibrosis Curcumin 22.2018705752
MESH:D005355 Fibrosis Cyclosporine 22.2012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.2018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.2020067830
MESH:D005355 Fibrosis Tretinoin 22.2017994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7516904648
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1718462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.688708960
MESH:D005909 Glioblastoma Curcumin 6.0817596214
MESH:D005909 Glioblastoma Tretinoin 6.0817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006258 Head and Neck Neoplasms Curcumin 6.6418829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.6416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.3120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.3110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.3114991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8815720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8511000095
MESH:D006505 Hepatitis Zymosan 4.1919110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 6.943609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9412621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5117701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.867520565
MESH:D006561 Herpes Simplex resveratrol 3.6516876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.7112676792
MESH:D006849 Hydrocephalus Valproic Acid 4.3317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5015340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.6312083418
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D006937 Hypercholesterolemia Cholesterol 23.4916933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 23.4910876104
MESH:D006937 Hypercholesterolemia Curcumin 23.4918704882
MESH:D006937 Hypercholesterolemia Dietary Fats 23.4921332399
MESH:D006937 Hypercholesterolemia resveratrol 23.4917188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0416778211
MESH:D006949 Hyperlipidemias Dietary Fats 7.6521332399
MESH:D006949 Hyperlipidemias resveratrol 7.6516873680
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 5.7118435438
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.0417604070
MESH:D006973 Hypertension Cyclosporine 7.2210903974
MESH:D006973 Hypertension Dexamethasone 7.2217042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.2218670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.1016612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.4117937319
MESH:D007248 Infertility, Male sodium arsenite 5.4112646999 15346721
MESH:D007249 Inflammation Curcumin 31.1416956363 18403477 17151092
MESH:D007249 Inflammation Dexamethasone 31.148960868 11099482
MESH:D007249 Inflammation Dietary Fats 31.1420412841
MESH:D007249 Inflammation Diethylnitrosamine 31.1418785209
MESH:D007249 Inflammation Flavonoids 31.1417296493
MESH:D007249 Inflammation Lipopolysaccharides 31.149205823 12878042 17255318 17237260 17963957
MESH:D007249 Inflammation perfluorooctanoic acid 31.1412083418
MESH:D007249 Inflammation resveratrol 31.1416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 31.1412878042 12200463
MESH:D007249 Inflammation Zymosan 31.148014878 11289658
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9718200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.0016624496
MESH:D007333 Insulin Resistance bisphenol A 6.2716393666
MESH:D007333 Insulin Resistance Dietary Fats 6.2718457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 3.2517994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.7510783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1317255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.3017553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.3316580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.3317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8915604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.1016144296
MESH:D007674 Kidney Diseases Cyclosporine 4.938314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 4.9320008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 5.8216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 5.8212371664
MESH:D007859 Learning Disorders Cholesterol 4.5817134702
MESH:D007889 Leiomyoma Curcumin 4.0718555241
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.261311351 2166429 8889330 19744259
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.1311332679
MESH:D007938 Leukemia arsenic trioxide 8.8215070760
MESH:D007938 Leukemia Curcumin 8.8218462866
MESH:D007938 Leukemia Tretinoin 8.8217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.1617077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.1616106398
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 16.5816972261
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 16.5816972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 16.5816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.0214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.8719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.8716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.3716467208 19850784 17050201 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.3717596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.3716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.669834237 17107899 16330433 16823087 15622746 16112521 17869043 19642359 15748426 17649720 15336539 19035177 12679006 15213294 17712046 16891316 17217047 11468182 16331271 19075265 12712474 16966277 19225113 12018890 11161223
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.6616087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.6617294898 17506722 19642359 17107899 17712046 12679006 16891316 16140955 16935935 19029980 16823087 17217047 17301526 17339181 9834237 16766008 19075265 19225113 16788101 16331271 19035177 15748426 17649720 17368321 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.0116882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.0116106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.1615821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.698812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.919224671
MESH:D008064 Lipidoses Ketoconazole 4.1817567588
MESH:D008103 Liver Cirrhosis Dietary Fats 5.5818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.5819638242 20032147 18407596 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental cis-9, trans-11-conjugated linoleic acid 7.6017869086
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 7.6018705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 7.6016718785
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.6018397230 16248980
MESH:D008107 Liver Diseases Curcumin 3.7116956363
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7117034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 33.137678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 33.1318177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 33.1314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.1321137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 33.1318177683
MESH:D008113 Liver Neoplasms ciprofibrate 33.1312771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 33.1310737359 20434301 21278145 18978307 19426721 19642983 18644402 15175105 20492335 2422723 19638242 21071580 20452335 19073162 18754104 18648771 19499222 20118626 19812893 19551842 20405173 19850985 20137499 19254457 12771043 19255062 21047994 19996281 12112319 9163691 19690152 16942905 19294768 21167192 20501860 20583210 18977376 2862719 15885732 19427195 19256749 20101389 19090486 19833225
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 33.1314757943 18709148
MESH:D008113 Liver Neoplasms resveratrol 33.1319812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 33.1316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.1316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.902876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.908603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.9020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.9018164116 18544905 2563599 3124819 19004024 19539802 18093689 16267830 17854601 18079962 18282651 17942915 19519916 19009564 16842330 18775883 18253720 9362446 18308698 17174075 19126423 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.9012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9415213294
MESH:D008171 Lung Diseases sodium arsenite 2.8019095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.7117228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.4921114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.9414755239
MESH:D008175 Lung Neoplasms alitretinoin 15.9416413115
MESH:D008175 Lung Neoplasms arsenic trioxide 15.9411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.9418520028 20064080 17053015 18816296 18569708 20869020 20135361 6695378 20464547
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 15.9416337739 18597497 19359593 15390079 11246140 19925653 11696405
MESH:D008175 Lung Neoplasms Curcumin 15.9418462866 19359593 16243823
MESH:D008175 Lung Neoplasms Dexamethasone 15.9415824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.9420512841 6695378 20970405 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 15.9419931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.9411884234 19555203
MESH:D008223 Lymphoma Curcumin 3.2018462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4314749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1716173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7115688416
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 5.401500032
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.4011606380 8985016
MESH:D008527 Medulloblastoma Tretinoin 2.5517453147
MESH:D008545 Melanoma Curcumin 6.3117885582 18462866
MESH:D008545 Melanoma resveratrol 6.3117992120
MESH:D008545 Melanoma sodium arsenite 6.3119082730 16487513
MESH:D008545 Melanoma Tretinoin 6.3116752155
MESH:D008569 Memory Disorders Curcumin 3.6517263510
MESH:D008591 Meningomyelocele Tretinoin 3.9016940565
MESH:D008659 Metabolic Diseases resveratrol 3.8917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2416801185
MESH:D008881 Migraine Disorders Valproic Acid 2.8018765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 14.0819417148 19549372 15949261 11468182 14977855
MESH:D009101 Multiple Myeloma Curcumin 14.0819372569
MESH:D009101 Multiple Myeloma Dexamethasone 14.0815744524 15867202 16118317
MESH:D009101 Multiple Myeloma resveratrol 14.0817935668 16490592 16267019 17049120 17164350 14749477
MESH:D009102 Multiple Organ Failure Zymosan 4.7118160304 10890648 12130978 15259001 15834315 15213630 10479408 12879239 15241586 17724436
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.6317962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.6317962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.548888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 14.8816105982 16882451
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 14.889809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 14.8817596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 14.8817596541
MESH:D009203 Myocardial Infarction resveratrol 2.7917188708 17015251 17125593 16317513 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.5817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.5812213967
MESH:D009205 Myocarditis resveratrol 4.2217322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.337678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.6316624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.6318495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.339029167 3581430
MESH:D009369 Neoplasms alitretinoin 9.5016946489
MESH:D009369 Neoplasms Benzo(a)pyrene 9.5011141357
MESH:D009369 Neoplasms sodium arsenite 9.5011559025
MESH:D009369 Neoplasms Tretinoin 9.5016594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 7.498985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.4920056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.9912497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8318481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 13.4211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.4214600291
MESH:D009421 Nervous System Malformations Tretinoin 13.429125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0818462866
MESH:D009436 Neural Tube Defects arsenic trioxide 14.3310525206
MESH:D009436 Neural Tube Defects sodium arsenite 14.3312854658
MESH:D009436 Neural Tube Defects Tretinoin 14.339142499
MESH:D009436 Neural Tube Defects Valproic Acid 14.3316359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0620387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.0617652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9017929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5720387270
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 17.239802331 20557099
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 17.239802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 17.239802331
MESH:D009765 Obesity Curcumin 4.2319297423
MESH:D009765 Obesity Dietary Fats 4.2321332399 18457598 17217161 20518802 11836018 20132043 18674790 16723640 19632207
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.9716049721
MESH:D010024 Osteoporosis Curcumin 3.1318719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.7617513867
MESH:D010049 Ovarian Diseases bisphenol A 4.4511985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 12.8419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 12.8419020741 18462866
MESH:D010051 Ovarian Neoplasms sodium arsenite 12.8417306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 12.8416936753
MESH:D010051 Ovarian Neoplasms U 0126 12.8416211241
MESH:D010146 Pain Tretinoin 2.4816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 10.4915580305
MESH:D010190 Pancreatic Neoplasms Curcumin 10.4917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.4916540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.6619927285
MESH:D010300 Parkinson Disease Cholesterol, Dietary 3.9519014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7012520081
MESH:D010538 Peritonitis Zymosan 4.3619088179 18977430 17371808 15979727 18557954 14761945 19641140 18760300 15259001 11985352 17826846
MESH:D011014 Pneumonia Butylated Hydroxytoluene 9.6011893704
MESH:D011014 Pneumonia Lipopolysaccharides 9.6012224865 11605937
MESH:D017499 Porokeratosis alitretinoin 5.4516144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0518163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.4312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.432563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2221297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 24.7810548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 24.7817132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 24.7816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 24.7811896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 24.7820603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0016740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.0011398177 18769126 18156803 10851300 18226269 12497104 15129424
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.0017404083
MESH:D011471 Prostatic Neoplasms resveratrol 2.0017636462 15767336 17804756 16731767 17675339 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0016039940
MESH:D011507 Proteinuria Tretinoin 3.1116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 3.9912752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0216882103
MESH:D011625 Pterygium Tretinoin 4.2516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2510548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.0619168576
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0316325855
MESH:D015427 Reperfusion Injury resveratrol 2.9916314181 17058453 15827377 16317513 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.6610666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.6618379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.2116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.2119155313
MESH:D012509 Sarcoma Curcumin 3.6518462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4516646077
MESH:D012559 Schizophrenia Valproic Acid 1.9915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 4.7118551238
MESH:D012640 Seizures Valproic Acid 4.7117978042 14763951 15475178 16876388 11044598 3137016 11738929 1511512
MESH:D018805 Sepsis Curcumin 8.2218389075
MESH:D018805 Sepsis Zymosan 8.2211441115
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.9410029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 14.948985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 14.9418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 14.9416467112
MESH:D019082 Smith-Lemli-Opitz Syndrome 24-hydroxycholesterol 6.0111254748
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.1512854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.1519490988
MESH:D013226 Status Epilepticus Valproic Acid 3.9912833885
MESH:D013272 Stomach Diseases Dexamethasone 3.7915472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.1317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.1320155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.1318456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.1317261132
MESH:D013276 Stomach Ulcer Curcumin 5.9719188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 5.9715138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0116321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.4516045194 16684133
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.5819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.587505956
MESH:D013964 Thyroid Neoplasms Tretinoin 9.5816026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 8.3516227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.3516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4315213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.6817262798
MESH:D014376 Tuberculosis Tretinoin 2.8816040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.983119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.2316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.2312845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.2317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 13.2318593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.2317306315 16452187 11723127 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.128888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.7318462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7810091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.1817473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.1811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.1816129372
MESH:D014591 Uterine Diseases bisphenol A 4.4614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.8114692618
MESH:D014594 Uterine Neoplasms resveratrol 7.8117044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.0616752155
MESH:D014605 Uveitis Cyclosporine 17.131336536
MESH:D014605 Uveitis Dexamethasone 17.131336536
MESH:D014605 Uveitis Zymosan 17.1311006244
MESH:D014652 Vascular Diseases sodium arsenite 3.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0615869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7817488730
MESH:D014820 Vitiligo Tretinoin 3.5516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7015886252
MESH:D015430 Weight Gain Dietary Fats 3.2816723640
MESH:D009396 Wilms Tumor Tretinoin 3.5116287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8917120751
Pathway ID Pathway Name
REACT:71 Gene Expression
KEGG:05160 Hepatitis C
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31751
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    PA444552Hypertension
    PA443796Coronary Artery Disease
    Releated drug ID Related drug Name
    PA145007158torcetrapib
    PA451868verapamil
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07080 - N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
    DB07929 - N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE
    DB08063 - 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
    DB08175 - (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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