AutismKB 2.0

Annotation Detail for DPP3


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Basic Information Top
Gene Symbol:DPP3 ( DPPIII,FLJ11387,FLJ22331 )
Gene Full Name: dipeptidyl-peptidase 3
Band: 11q13.2
Quick LinksEntrez ID:10072; OMIM: 606818; Uniprot ID:DPP3_HUMAN; ENSEMBL ID: ENSG00000174483; HGNC ID: 3008
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]decreases reaction|increases expression 17360324
D000082 Acetaminophen Acetaminophen affects the expression of DPP3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DPP3 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of DPP3 proteinincreases expression 18418863
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of DPP3 mRNAdecreases expression 16239168
D016572 Cyclosporine Cyclosporine results in decreased expression of DPP3 mRNAdecreases expression 20106945
D004743 Enkephalin, Leucine DPP3 protein results in increased cleavage of Enkephalin, Leucineincreases cleavage 10873616
D004743 Enkephalin, Leucine spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]decreases reaction|increases cleavage 10873616
D004743 Enkephalin, Leucine tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]decreases reaction|increases cleavage 10873616
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DPP3 mRNAaffects cotreatment|increases expression 17942748
D006861 Hydrogen Peroxide DPP3 protein results in decreased susceptibility to Hydrogen Peroxidedecreases response to substance 17360324
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]decreases reaction|increases expression 17360324
D012402 Rotenone DPP3 protein results in decreased susceptibility to Rotenonedecreases response to substance 17360324
C017947 sodium arsenite sodium arsenite results in decreased expression of DPP3 mRNAdecreases expression 16014739
D018038 Sodium Selenite Sodium Selenite results in increased expression of DPP3 mRNAincreases expression 18175754
C082392 spinorphin spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]decreases reaction|increases cleavage 10873616
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DPP3 mRNAaffects cotreatment|increases expression 17942748
C412863 tynorphin tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]decreases reaction|increases cleavage 10873616
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9316712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0617123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916097048 15721981 16192424 15700767 16011737 16227642 3786805 15673190 16050911 10355542 18705752 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.553084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5518788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.5516507464 15276417 17306315
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3818572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5116936243
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6612371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.6619524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 7.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7816919318 11677210 16105132 17110522 17681005 15861022 17333356
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015668235 15340226 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9716177239 19923254 11834606 12540782 19739265 17562736 11287661 19164858 16081117 16485898 12705907 12153990 17906064 12958197 16109766 14550746 14986274 12594235 18071297 19370779 16227642 10663392 19085960 19420014 15968718 10774834 10915739 11529661 19416960 17522070 11461765 2444490 18713872 12392966 11743745 16393943 14725611 11421492 16781746 15619225 11739529
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.977179309 4309450 3732212 19336974 15027814 17522070 7120509 11566570 6623471 15968718 3786805 10915739 15998439 16227642 6884620 9327722 10092053 2869522 19085960 21278145 16177239 7440962
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.9715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004832 Epilepsy, Absence Enkephalin, Leucine 6.666254150
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.0912795759 61145 12631006 17595544 15959796 16045604 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 13.0919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 14.8018705752
MESH:D005355 Fibrosis Cyclosporine 14.8012639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.8020067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6517937319
MESH:D007248 Infertility, Male sodium arsenite 6.6515346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.5616393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.5614714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.018314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 10.0120008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7412371664
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.8012970779
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8111408273 16943688 21278145 16221502 17334410 11903743 17174718 17157831 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.2816248980 16015684 17557913 16638106 15730626 15925388 17640975 17761835 15876570 14716496 12445421 17481882 12546737 18472094 18418968 14512876 12667390 17869086 12632514 17708605 15673190 18006644 12958196 14620537 13678700 15052691 18156304 18472332 18210741 12649538 17525996 18277467 12898905 17805973 18279442 17900296 15893842 12666154 15650968 18376398 17721639 16136751 18481824 17823541 10355542 12389079 18420326 14748882 17565644 18251166 17631135 17714472 16192424 15338365 12632512 16011737 17944888 18412020 18317297 18395914 15057751 15818738 18705752 16097048 16116963 12445418 18395095 17698563 12609069 18054572 18166357 15370692 18187930 16033810 18339082 17922224 16027843 15931870 15362042 14716833 18263696 12741479 15123356 12586293 17766677 11481614 18429990 20821823 17976157 15959796 15996030 18205269 14724832
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008107 Liver Diseases Acetaminophen 3.9012969438 12587719 19784758 11587558 19460945 16611625 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9016246199 15720792 16964402 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.4119294768
MESH:D008113 Liver Neoplasms sodium arsenite 7.4116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7612151625
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3017077188 16712894 17306315 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009369 Neoplasms sodium arsenite 2.5011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.8818619942 17356569 15790535
MESH:D009421 Nervous System Malformations bisphenol A 9.6111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1412854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 5.2716211241
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2717306315 15276417
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.1012065085
MESH:D010300 Parkinson Disease Rotenone 2.9816412576 15451049 19232380 11535288 18619942 11445065 16140633 18191903 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 4.0815927086 15795934 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.5810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5811118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6316740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6316039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6318760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.5012065085
MESH:D012878 Skin Neoplasms sodium arsenite 9.5018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5116712894 11723127 17306315 16452187
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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