AutismKB 2.0

Annotation Detail for PTPRU


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Basic Information Top
Gene Symbol:PTPRU ( FLJ37530,FMI,GLEPP1,PCP-2,PTP,PTP-J,PTP-PI,PTPPSI,PTPRO,PTPU2,R-PTP-PSI,hPTP-J )
Gene Full Name: protein tyrosine phosphatase, receptor type, U
Band: 1p35.3
Quick LinksEntrez ID:10076; OMIM: 602454; Uniprot ID:PTPRU_HUMAN; ENSEMBL ID: ENSG00000060656; HGNC ID: 9683
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRU mRNAaffects expression 16483693
D004958 Estradiol Estradiol affects the expression of PTPRU mRNAaffects expression 14699072
D014212 Tretinoin Tretinoin results in decreased expression of PTPRU mRNAdecreases expression 16012519
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4416456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0916197459 16206674
MESH:D001943 Breast Neoplasms Estradiol 2.1116675129 17289903 17261762 18497071 19861407 17018787 14630087 12948864
MESH:D001943 Breast Neoplasms Tretinoin 2.1116443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.161917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3816051514 16096774
MESH:D002386 Cataract Tretinoin 3.3217460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Tretinoin 4.3517035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9664655 16925845 9224671 8800419 9142499 17551590 9125849 9211117 14991402
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D016889 Endometrial Neoplasms Estradiol 8.3218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 8.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.909664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005909 Glioblastoma Tretinoin 3.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.099664655 14991402
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D006930 Hyperalgesia Tretinoin 3.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D007333 Insulin Resistance Estradiol 3.2316627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3917551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.8015618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3615610895
MESH:D007938 Leukemia Tretinoin 2.9517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1319850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4217361223 19225113 17339181 16766008 17217047 16140955 9834237 15748426 17368321 17301526 19035177 19029980 19642359 16935935 17712046 16331271 16823087 17506722 17649720 12679006 17107899 19075265 17294898 16788101 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5718397230 16248980
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.8216891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3017596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6216810080
MESH:D009369 Neoplasms Tretinoin 2.5916594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009421 Nervous System Malformations Estradiol 11.6916427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 11.699125849
MESH:D009436 Neural Tube Defects Tretinoin 3.329142499
MESH:D010051 Ovarian Neoplasms Estradiol 5.1619401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1616936753
MESH:D010146 Pain Tretinoin 3.2816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5815976015
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34028
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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