AutismKB 2.0

Annotation Detail for PDCD7


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Basic Information Top
Gene Symbol:PDCD7 ( ES18,HES18,MGC22015 )
Gene Full Name: programmed cell death 7
Band: 15q22.31
Quick LinksEntrez ID:10081; OMIM: 608138; Uniprot ID:PDCD7_HUMAN; ENSEMBL ID: ENSG00000090470; HGNC ID: 8767
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PDCD7 mRNAaffects expression 21346803
C006780 bisphenol A bisphenol A results in increased expression of PDCD7 mRNAincreases expression 19371625
D015025 Zearalenone Zearalenone results in increased expression of PDCD7 mRNAincreases expression 19371625
D019833 Genistein Genistein results in increased expression of PDCD7 mRNAincreases expression 19371625
C016340 o,p'-DDT o,p'-DDT results in increased expression of PDCD7 mRNAincreases expression 19371625
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PDCD7 mRNAaffects binding|decreases expression|increases activity 19710929
C059514 resveratrol resveratrol results in increased expression of PDCD7 mRNAincreases expression 19371625
D014501 Uranium Uranium affects the expression of PDCD7 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of PDCD7 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.0616538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D000236 Adenoma resveratrol 3.4215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000544 Alzheimer Disease resveratrol 2.6016162502 16183991
MESH:D001169 Arthritis, Experimental resveratrol 3.6217115116
MESH:D050197 Atherosclerosis resveratrol 3.3816873680 17967414
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D002545 Brain Ischemia resveratrol 4.5717600658
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Genistein 2.0317200150 16873071 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.0317534123 17651959 16393696
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8416705839
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8416924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.8419321006 16227395
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7616227395
MESH:D002318 Cardiovascular Diseases Genistein 7.9716332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.9715458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003092 Colitis resveratrol 4.3916474422
MESH:D003110 Colonic Neoplasms Genistein 4.0417182828
MESH:D003110 Colonic Neoplasms resveratrol 4.0416338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8716507316
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9416873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D003928 Diabetic Nephropathies resveratrol 4.1416286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0218551238 21346803
MESH:D004487 Edema pirinixic acid 7.5912083418
MESH:D004487 Edema resveratrol 7.598985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2617872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.8716402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4911473722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1117923197
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D005909 Glioblastoma Genistein 3.3816598420
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 19772884 18467677
MESH:D006561 Herpes Simplex resveratrol 4.4616876885
MESH:D006937 Hypercholesterolemia resveratrol 4.2117188708
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias resveratrol 4.2516873680
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5017488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9117600658
MESH:D007249 Inflammation resveratrol 2.9416366677
MESH:D007251 Influenza, Human resveratrol 4.8616624496
MESH:D007333 Insulin Resistance bisphenol A 7.7416393666
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D007938 Leukemia Genistein 3.1118980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7016087638
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4915474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.867678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.8620007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 7.8619073162 19321006 19812893 20405173
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.662876786 2876784 6135515
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0414749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5315688416
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.7112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.7111606380 8985016
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008659 Metabolic Diseases resveratrol 4.5817112576
MESH:D009101 Multiple Myeloma resveratrol 3.6117935668 17049120 16267019 17164350 14749477 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction Genistein 9.9417141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.9419151258
MESH:D009203 Myocardial Infarction resveratrol 9.9416456233 16317513 17125593 16525036 17015251 17188708
MESH:D017202 Myocardial Ischemia resveratrol 4.1717125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9216411023
MESH:D009205 Myocarditis resveratrol 5.0417322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.268985016
MESH:D009421 Nervous System Malformations bisphenol A 10.6911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 10.6916427766
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6217929310
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010024 Osteoporosis Genistein 3.3719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.9016169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.9017513867
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6519005980
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.8410548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.8416679765
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6415256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms resveratrol 2.6417804756 17636462 16731767 17675339 17718901 15767336
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.8719058328
MESH:D015427 Reperfusion Injury resveratrol 6.8717520802 16314181 16317513 17058453 15827377
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms resveratrol 3.1115837718 8985016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6716321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716684133 16045194
MESH:D014062 Tongue Neoplasms resveratrol 4.4116227395
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3516049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2917473185
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014594 Uterine Neoplasms resveratrol 4.3717044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5617488730
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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