AutismKB 2.0

Annotation Detail for GPC6


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Basic Information Top
Gene Symbol:GPC6 ( MGC126288,OMIMD1 )
Gene Full Name: glypican 6
Band: 13q31.3-q32.1
Quick LinksEntrez ID:10082; OMIM: 604404; Uniprot ID:GPC6_HUMAN; ENSEMBL ID: ENSG00000183098; HGNC ID: 4454
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
tonometry
Desease Name
Neuroticism
Tonometry
Attention deficit hyperactivity disorder
Desease Name
Omodysplasia 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GPC6 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GPC6 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GPC6 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of GPC6 mRNAaffects expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GPC6 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of GPC6 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616011737 15673190 16124888 16227642 16050911 15721981 16097048 15700767 18705752 10355542 3786805 16192424
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1918788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3512371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.117120509 11566570 7440962 7179309 3786805 15027814 19336974 3732212 16227642 6623471 16177239 15998439 10915739 9327722 17522070 4309450 2869522 19085960 15968718 6884620 10092053 21278145
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9712631006 19224547 15959796 16045604 12795759 16239168 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 8.9719224547
MESH:D005355 Fibrosis Carbon Tetrachloride 10.3318705752
MESH:D005355 Fibrosis Cyclosporine 10.3312639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9817174718 16943688 16221502 11408273 17334410 11903743 21278145 17157831 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518205269 12445418 14716833 12666154 18705752 17823541 15362042 14512876 17944888 15370692 15123356 17869086 13678700 14716496 18263696 16638106 17976157 17922224 18166357 18210741 18156304 15730626 12741479 18277467 15052691 16248980 16192424 14620537 18481824 15925388 17565644 18006644 15959796 12389079 15650968 15673190 15931870 17698563 17631135 12632514 16033810 15818738 18279442 17761835 18395095 17481882 18187930 18054572 15057751 14748882 14724832 12649538 15876570 15338365 15893842 17805973 18317297 18472094 16116963 17708605 12586293 16015684 10355542 18472332 17900296 16136751 17766677 18418968 16097048 18395914 12609069 17640975 11481614 12546737 18429990 17525996 12632512 12898905 16011737 18412020 20821823 17557913 18420326 12667390 12958196 12445421 18339082 18251166 17721639 18376398 16027843 17714472 15996030
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516964402 15830285 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.102125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1021137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1019294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.688603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6815583823 12014681
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.506695378 18569708 18520028 17053015 20064080 18816296 20135361 20464547 20869020
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
OMIM:258315 OMODYSPLASIA 1 marker/mechanism
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5119755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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