Annotation Detail for USH1C
Basic Information
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| Gene Symbol: | USH1C ( AIE-75,DFNB18,NY-CO-37,NY-CO-38,PDZ-45,PDZ-73,PDZ-73/NY-CO-38,PDZ73,ush1cpst ) |
|---|
| Gene Full Name: | Usher syndrome 1C (autosomal recessive, severe) |
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| Band: | 11p15.1 |
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| Quick Links | Entrez ID:10083; OMIM: 605242; Uniprot ID:USH1C_HUMAN; ENSEMBL ID: ENSG00000006611; HGNC ID: 12597 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease ID | Desease Name |
|---|
| 2207 | Deafness |
| Desease Name |
|---|
| Usher syndrome, type 1C |
| Deafness, autosomal recessive 18 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D008727 |
Methotrexate |
USH1C protein affects the susceptibility to Methotrexate | affects response to substance | 16217747
|
| C079198 |
S 1 (combination) |
USH1C protein results in increased susceptibility to S 1 (combination) | increases response to substance | 16734730
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Methotrexate |
5.13 | 12039119 |
| MESH:D001172 |
Arthritis, Rheumatoid |
|
Methotrexate |
3.18 | 17286800 |
| MESH:D001943 |
Breast Neoplasms |
|
Methotrexate |
3.06 | 16978400 |
| MESH:D002289 |
Carcinoma, Non-Small-Cell Lung |
|
S 1 (combination) |
4.19 | 18212800 18347146 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
S 1 (combination) |
3.95 | 15984520 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Methotrexate |
2.67 | 9562676 12039119 |
| MESH:D003550 |
Cystic Fibrosis |
|
Methotrexate |
4.74 | 19747007 |
| OMIM:602092 |
DEAFNESS, AUTOSOMAL RECESSIVE 18 |
marker/mechanism |
|
| |
| MESH:D003882 |
Dermatomyositis |
|
Methotrexate |
5.80 | 20191521 |
| MESH:D005706 |
Gallbladder Neoplasms |
|
S 1 (combination) |
6.44 | 19093184 |
| MESH:D006086 |
Graft vs Host Disease |
|
Methotrexate |
5.91 | 16518429 |
| MESH:D006258 |
Head and Neck Neoplasms |
|
S 1 (combination) |
5.06 | 18607998 15984520 |
| MESH:D007805 |
Language Development Disorders |
|
Methotrexate |
5.71 | 9562676 |
| MESH:D008103 |
Liver Cirrhosis |
|
Methotrexate |
3.93 | 14986274 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Methotrexate |
6.09 | 18516814 |
| MESH:D008223 |
Lymphoma |
|
Methotrexate |
4.29 | 17352296 |
| MESH:D052016 |
Mucositis |
|
Methotrexate |
6.17 | 17488658 |
| MESH:D011565 |
Psoriasis |
|
Methotrexate |
3.56 | 17410198 |
| MESH:D051437 |
Renal Insufficiency |
|
Methotrexate |
5.47 | 17352296 |
| MESH:D013274 |
Stomach Neoplasms |
|
S 1 (combination) |
3.37 | 16557585 18553229 18506536 |
| MESH:D013576 |
Syndactyly |
|
Methotrexate |
5.71 | 9562676 |
| OMIM:276904 |
USHER SYNDROME, TYPE IC |
marker/mechanism |
|
| |
PharmGKB Accession:PA37226
| Releated disease ID |
Related disease Name |
| PA443840 | Deafness |
Related Pathway Information