AutismKB 2.0

Annotation Detail for EDIL3


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Basic Information Top
Gene Symbol:EDIL3 ( DEL1,MGC26287 )
Gene Full Name: EGF-like repeats and discoidin I-like domains 3
Band: 5q14.3
Quick LinksEntrez ID:10085; OMIM: 606018; Uniprot ID:EDIL3_HUMAN; ENSEMBL ID: ENSG00000164176; HGNC ID: 3173
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200109Integrins in angiogenesis
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
2004Solid tumor
Desease Name
CARDIOVASCULAR
plasma chemerin levels
Desease Name
Plasma chemerin levels
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EDIL3 mRNAincreases expression 17879257
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of EDIL3 mRNAdecreases expression 15336504
D003474 Curcumin Curcumin results in decreased expression of EDIL3 mRNAdecreases expression 18421014
D005472 Fluorouracil EDIL3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D013629 Tamoxifen Tamoxifen affects the expression of EDIL3 mRNAaffects expression 14699072
D014415 Tunicamycin Tunicamycin results in increased expression of EDIL3 mRNAincreases expression 17127020
D014635 Valproic Acid Valproic Acid results in increased expression of EDIL3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5920464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.5917638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D019973 Alcohol-Related Disorders Curcumin 5.5217887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000740 Anemia Fluorouracil 3.9815504547 17963324 16511603
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D050197 Atherosclerosis Curcumin 3.4718704882
MESH:D001321 Autistic Disorder Valproic Acid 1.9917507914 18177632 17157402 17688650 18985861 16609825 18316065 19232924 20603192 19460635 15238991 18775368 18558336 18396377 18940202
MESH:D001327 Autoimmune Diseases Curcumin 4.8519761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D002545 Brain Ischemia Curcumin 4.7316770732
MESH:D001932 Brain Neoplasms Curcumin 4.2017596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 2.0118462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Fluorouracil 2.0115136595 16557594 19217205 18608205 16595493 16110121 18357371
MESH:D001943 Breast Neoplasms Tamoxifen 2.0116202921 19115204 16273361 18855134 19059307 19155303 19103187 19288272 19142967 19189212 16818667 15565566 19244106 20135344 19066611 11161223 17440819 18815881 19487384 20859285 18984771 18629630 17049068 19084267 19200415 15668708 20065188 18351453 21152245 20544844 20390343 19221464 18997820 17893378 18821012 19189210 21138602 19011961 17261762 19289846 19410462 17242785 20005174 16873071 18425577
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Curcumin 9.3218593918
MESH:D002277 Carcinoma Fluorouracil 9.3217121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2116332177 17088986 18930000 16799960 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2116924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0518414057
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.9918462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.9917066447 18986760 16757204 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D003092 Colitis Curcumin 4.5316782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.8318809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0716340194 19359593
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0717172411 17016597 18772588 17169374 17018589 16510598 17287894 15001691 16340194 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016303861 18949393 20501625 18288408 18509181 17016601 16331619 17094418 18383874 15289873 16524972 14970324 15148649 18448328 17401013 17255274 17454858 17594712 16282729 16391804 17695437 18802399
MESH:D016510 Corneal Neovascularization Curcumin 5.2618497527
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.9018204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.9019279558
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2319641884 1733752
MESH:D004381 Duodenal Ulcer Curcumin 4.3817351913
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.8719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2117893378 16202921 20544844 19155303
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6816337965 16785472 15173087 16481741 17638652
MESH:D005234 Fatty Liver Curcumin 14.9319297423
MESH:D005234 Fatty Liver Tamoxifen 14.9319224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 14.9319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Curcumin 4.3418705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0518462866
MESH:D005909 Glioblastoma Curcumin 3.6417596214
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006258 Head and Neck Neoplasms Curcumin 8.5618462866 18829502
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.5618337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4017701891
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006937 Hypercholesterolemia Curcumin 4.3318704882
MESH:D007249 Inflammation Curcumin 5.7018403477 16956363 17151092
MESH:D007249 Inflammation Tamoxifen 5.7019457130
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3018596194 18200517
MESH:D007414 Intestinal Neoplasms Curcumin 4.4810783313
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3018625569
MESH:D007889 Leiomyoma Curcumin 4.8818555241
MESH:D007938 Leukemia Curcumin 3.3618462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4916106398
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D015458 Leukemia, T-Cell Curcumin 5.0916106398
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.7318705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.7318564211
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9920195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.9917045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 7.9916684651
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.1020135361 20064080 6695378 20869020 18520028 18816296 17053015 20464547 18569708
MESH:D008175 Lung Neoplasms Curcumin 5.1019359593 18462866 16243823
MESH:D008175 Lung Neoplasms Fluorouracil 5.1015246190
MESH:D008175 Lung Neoplasms Tamoxifen 5.1018625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D008223 Lymphoma Curcumin 3.7818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0516173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Curcumin 3.5818462866 17885582
MESH:D008545 Melanoma Tamoxifen 3.5812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008569 Memory Disorders Curcumin 4.4817263510
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.2416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.2416757204 18986760
MESH:D009101 Multiple Myeloma Curcumin 3.7019372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3117962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7018495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4711141357
MESH:D009369 Neoplasms Fluorouracil 5.4718600527 16928823 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 12.3712497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 12.3719200415 19196722 19189210
MESH:D009423 Nervous System Neoplasms Curcumin 6.0718462866
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D009765 Obesity Curcumin 2.8019297423
MESH:D010024 Osteoporosis Curcumin 3.6218719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 5.7919196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.7915113037 19003803 16500647 16929163
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.0511398177 18769126 15129424 10851300 12497104 18156803 18226269
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0519082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.7919168576
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2618286688 18722050 16160472 15538739
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3310666014 18379247
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012509 Sarcoma Curcumin 4.3818462866
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.913137016 1511512 11044598 15475178 16876388 11738929 14763951 17978042
MESH:D018805 Sepsis Curcumin 4.3118389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0919755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.098532709
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4720155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4718567086 17522103 19015929 16424979 15786421 18396642 17498489 19084572 16951190 17172411
MESH:D013276 Stomach Ulcer Curcumin 3.7719188055 16631530
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9017053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.9018593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9017572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.6618462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
No data
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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