AutismKB 2.0

Annotation Detail for CDH11


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Basic Information Top
Gene Symbol:CDH11 ( CAD11,CDHOB,OB,OSF-4 )
Gene Full Name: cadherin 11, type 2, OB-cadherin (osteoblast)
Band: 16q21
Quick LinksEntrez ID:1009; OMIM: 600023; Uniprot ID:CAD11_HUMAN; ENSEMBL ID: ENSG00000140937; HGNC ID: 1750
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell junction organization
No data
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CDH11 mRNAincreases expression 20406850
C016392 3,3'-diindolylmethane 3,3'-diindolylmethane results in decreased expression of CDH11 proteindecreases expression 18025290
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of CDH11 mRNAdecreases expression 19901195
D000537 Aluminum Oxide Aluminum Oxide results in increased expression of CDH11 mRNAincreases expression 19464052
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDH11 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of CDH11 mRNAdecreases expression 19654921
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH11 mRNAaffects cotreatment|increases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CDH11 mRNAdecreases expression 12419474
D003474 Curcumin Curcumin results in decreased expression of CDH11 proteindecreases expression 18025290
C014347 decitabine decitabine results in decreased expression of CDH11 mRNAdecreases expression 18025290
C014347 decitabine decitabine results in decreased expression of CDH11 proteindecreases expression 18025290
D004041 Dietary Fats Dietary Fats results in increased expression of CDH11 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH11 mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDH11 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of CDH11 mRNAdecreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CDH11 mRNAdecreases expression 17351261
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CDH11 mRNAdecreases expression 12419474
D018021 Lithium Chloride CTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein]affects reaction|decreases activity|decreases expression 19274078
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 mRNAdecreases activity|decreases expression 19274078
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 proteindecreases activity|decreases expression 19274078
D015735 Mifepristone Mifepristone results in increased expression of CDH11 mRNAincreases expression 17584828
D017239 Paclitaxel Paclitaxel results in increased expression of CDH11 mRNAincreases expression 19682730
C041786 palm oil palm oil results in increased expression of CDH11 mRNAincreases expression 18042831
D011794 Quercetin Quercetin results in increased expression of CDH11 mRNAincreases expression 15309432
D012643 Selenium Selenium results in decreased expression of CDH11 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of CDH11 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDH11 mRNAdecreases expression 18495758
16443690
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDH11 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDH11 mRNAdecreases expression 19619570
19901195
C012589 trichostatin A trichostatin A results in decreased expression of CDH11 mRNAdecreases expression 18025290
C012589 trichostatin A trichostatin A results in decreased expression of CDH11 proteindecreases expression 18025290
D014635 Valproic Acid Valproic Acid results in increased expression of CDH11 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of CDH11 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.618875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000230 Adenocarcinoma Estradiol 4.0411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0414692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.4819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.4810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.3516434500 19052882 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3516835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0017306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8717887948
MESH:D000544 Alzheimer Disease Curcumin 2.5715590663
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0517084956
MESH:D001008 Anxiety Disorders Valproic Acid 8.3117497229
MESH:D001008 Anxiety Disorders vinclozolin 8.3119015723
MESH:D020261 Arsenic Poisoning Arsenic 2.8112569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6916807698
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7715336622
MESH:D050197 Atherosclerosis Arsenic 6.5019371607 12928151
MESH:D050197 Atherosclerosis Curcumin 6.5018704882
MESH:D001321 Autistic Disorder Valproic Acid 2.0220603192 17688650 15238991 19232924 18316065 18177632 17507914 19460635 16609825 18775368 18396377 18985861 18940202 17157402 18558336
MESH:D001327 Autoimmune Diseases Curcumin 10.1819761891
MESH:D001327 Autoimmune Diseases Quercetin 10.1819761891
MESH:D001714 Bipolar Disorder Valproic Acid 2.9720046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.588888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.3715867366
MESH:D002545 Brain Ischemia Curcumin 4.1216770732
MESH:D001932 Brain Neoplasms Curcumin 3.7617596214
MESH:D001943 Breast Neoplasms Curcumin 5.6216243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms decitabine 5.6219208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 5.6220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6217474063
MESH:D001943 Breast Neoplasms Estradiol 5.6219861407 14630087 17289903 17018787 16675129 17261762 12948864 18497071
MESH:D001943 Breast Neoplasms Paclitaxel 5.6218234424 16244791 18223236 18323546 16115903 15136595 11325840 16273361
MESH:D001943 Breast Neoplasms Quercetin 5.6218628248
MESH:D001943 Breast Neoplasms Tamoxifen 5.6211161223 20005174 19084267 17261762 20135344 20859285 19011961 19200415 17893378 16873071 18815881 17049068 19221464 15668708 18351453 21138602 18855134 18425577 19189212 17440819 19155303 19103187 19189210 20390343 17242785 21152245 18997820 18984771 18629630 20544844 19066611 19288272 18821012 15565566 16818667 19115204 16202921 19487384 19244106 19289846 20065188 19410462 16273361 19142967 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D002105 Cadmium Poisoning Quercetin 5.3316962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Curcumin 7.7418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4817687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.5516507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5516328049 19519916 17055752 19701751 19208518 20084675 20727157 17173139 16569478 16807293 16878318 19171122 18393292 19539802 20512989 18506893 19919837 16288022 18788625 17978847 19383236 18785209 19107877 20524982 16502159 17138121 10672840 19394651 18971187 11831363 10737359 20007298 18210153 18494052 20214788 18056438 16935385 16698587 18665156 21159647 19418558 20432363 17761372 16830150 20514400 20935162 19052882 18691550 20101231 16540662 3084413 16681979 17162532 17428255 19822196 3581430 19335982 18978308 16779866
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.5516313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.5512508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.5516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7517234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.3215504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.3218462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.3219215824
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.8918640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8917572228
MESH:D006332 Cardiomegaly Quercetin 6.4219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 7.1015738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.1016936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.1318022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.366135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.362727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3618566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7217681005 16105132 17110522 16919318 11677210 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0216354765 15668235 12621046 15340226 8697196
MESH:D003092 Colitis Curcumin 8.9816804969 18200517 16782535
MESH:D003092 Colitis Selenium 8.9817936198
MESH:D003103 Coloboma Curcumin 4.3618809619
MESH:D003110 Colonic Neoplasms Curcumin 5.7019359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 5.7017616700
MESH:D003110 Colonic Neoplasms Quercetin 5.7019056647 17148506 17191121 19440933 11134977 16640504 15741050
MESH:D015179 Colorectal Neoplasms decitabine 3.4718981723
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.4718802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.4718852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.6918497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4117688650 16575769 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8118551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5619496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.8218403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8217107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.0118204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.0119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0119279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.3318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 11.3315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.3319641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8517351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3018367378
MESH:D004421 Dystonia Valproic Acid 3.851851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6916714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2819031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.3219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.3219294695
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 11.7819148513
MESH:D016889 Endometrial Neoplasms Estradiol 11.7819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.7816202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Mifepristone 8.5416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.549294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.713922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.416254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.097750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.853659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.8416481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Curcumin 28.2619297423
MESH:D005234 Fatty Liver Dietary Fats 28.2619551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 28.2621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.2615345470
MESH:D005234 Fatty Liver Tamoxifen 28.2614986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 28.2614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9318558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Curcumin 19.4918705752
MESH:D005355 Fibrosis Dietary Fats 19.4918296743
MESH:D005355 Fibrosis Quercetin 19.4919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.4920067830
MESH:D005534 Foot Diseases Arsenic 5.356392382
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4918462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005909 Glioblastoma Curcumin 11.2917596214
MESH:D005909 Glioblastoma Quercetin 11.2919804834
MESH:D005909 Glioblastoma trichostatin A 11.2918801729
MESH:D005910 Glioma Quercetin 2.9717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.5418462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 7.5419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2210048152 11294989
MESH:D006333 Heart Failure Selenium 2.9517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6912621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8317701891
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D006869 Hydronephrosis Lithium Chloride 12.3219797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 12.3216959395 15340226 18606429 8697196 16354765
MESH:D006937 Hypercholesterolemia Curcumin 8.6018704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.6021332399
MESH:D006943 Hyperglycemia Quercetin 3.8511834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2717050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006973 Hypertension Arsenic 8.229931084 11953799 16076760
MESH:D006973 Hypertension Quercetin 8.2218356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2218850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.3516093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male decitabine 10.4317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4317937319
MESH:D007248 Infertility, Male vinclozolin 10.4316467254
MESH:D007249 Inflammation Curcumin 14.7116956363 18403477 17151092
MESH:D007249 Inflammation Dietary Fats 14.7120412841
MESH:D007249 Inflammation Diethylnitrosamine 14.7118785209
MESH:D007249 Inflammation Tamoxifen 14.7119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.7112878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318200517 18596194
MESH:D007251 Influenza, Human Quercetin 10.3616624496
MESH:D007251 Influenza, Human Selenium 10.3616624496
MESH:D007333 Insulin Resistance Dietary Fats 6.9211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.9216393666 16627594
MESH:D007414 Intestinal Neoplasms Curcumin 4.0410783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007627 Keloid Quercetin 4.7517086741
MESH:D007642 Keratosis Arsenic 4.7816930632 12749816
MESH:D007674 Kidney Diseases Estradiol 5.8215618244
MESH:D007674 Kidney Diseases Quercetin 5.8216962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.4016518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.4016518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.4216705839
MESH:D007680 Kidney Neoplasms Estradiol 11.4215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.4218625569
MESH:D007889 Leiomyoma Curcumin 4.3818555241
MESH:D007938 Leukemia Curcumin 10.0118462866
MESH:D007938 Leukemia decitabine 10.0118980019 19235587
MESH:D007938 Leukemia Quercetin 10.0117468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0216106398
MESH:D007951 Leukemia, Myeloid decitabine 3.8117236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0317679729 18206229 18460780 19010910 18704418 19387464
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.0318206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.0317596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4217339181
MESH:D015458 Leukemia, T-Cell Curcumin 4.5616106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.6317353645
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2520032147 19638242 18522880 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.4518705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.4512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4512878042
MESH:D008107 Liver Diseases Arsenic 6.3411134558
MESH:D008107 Liver Diseases Curcumin 6.3416956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3417034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.687678174
MESH:D008113 Liver Neoplasms Arsenic 20.6816368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.6821295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.6816942905 18978307 20583210 19090486 19996281 20101389 19255062 18754104 19256749 19254457 9163691 19294768 21047994 2422723 19833225 20434301 15885732 15175105 19642983 18977376 21167192 19812893 21071580 18644402 19427195 19850985 2862719 19551842 19073162 20452335 19499222 18648771 19638242 20501860 20492335 20118626 10737359 12771043 19426721 21278145 12112319 20137499 20405173 19690152
MESH:D008113 Liver Neoplasms Quercetin 20.6818980244
MESH:D008113 Liver Neoplasms Tamoxifen 20.6816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.6816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.282876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.2818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.2817942915 19539802 18253720 18079962 18164116 18544905 19004024 2563599 18282651 18775883 19519916 17854601 19126423 16267830 3124819 17174075 18308698 19009564 18093689 21159647 16842330 9362446
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.2819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.2812151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0517228818
MESH:D008175 Lung Neoplasms Arsenic 8.2119168569 17976673 17306315
MESH:D008175 Lung Neoplasms Curcumin 8.2116243823 19359593 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2121163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Quercetin 8.2116280456
MESH:D008175 Lung Neoplasms Tamoxifen 8.2118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2119555203 11884234
MESH:D008223 Lymphoma Curcumin 7.2818462866
MESH:D008223 Lymphoma decitabine 7.2819470736
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9214749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4916173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1817203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.1815318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.1814580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008545 Melanoma Curcumin 9.4117885582 18462866
MESH:D008545 Melanoma decitabine 9.4116505122 17785578
MESH:D008545 Melanoma Paclitaxel 9.4112025231 16342250 12040289
MESH:D008545 Melanoma Tamoxifen 9.4119393235 12393984
MESH:D008545 Melanoma trichostatin A 9.4116505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008569 Memory Disorders Curcumin 3.9517263510
MESH:D008654 Mesothelioma Selenium 2.7115107826
MESH:D008881 Migraine Disorders Valproic Acid 3.0418765137 18803445
MESH:D009101 Multiple Myeloma Curcumin 16.1319372569
MESH:D009101 Multiple Myeloma decitabine 16.1318172295
MESH:D009101 Multiple Myeloma Paclitaxel 16.1314749477
MESH:D009101 Multiple Myeloma trichostatin A 16.1318172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7117962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.1118608210 19157545 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1117596541
MESH:D009203 Myocardial Infarction Quercetin 2.9119595682
MESH:D017202 Myocardial Ischemia Arsenic 8.4515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0316810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.0319207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.657678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1718495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.089029167 3581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.0815867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.0819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms decitabine 4.9917925555 19116145 19470736
MESH:D009369 Neoplasms Quercetin 4.9915185748
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.1312497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.1319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009421 Nervous System Malformations Estradiol 8.7916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4218462866
MESH:D009436 Neural Tube Defects Arsenic 7.0016620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.0016359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D020078 Neurogenic Inflammation Arsenic 10.0317056641
MESH:D020078 Neurogenic Inflammation Quercetin 10.0317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009765 Obesity Curcumin 4.6019297423
MESH:D009765 Obesity Dietary Fats 4.6021332399 11836018 19632207 20132043 18674790 17217161 20518802 16723640 18457598
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2516049721
MESH:D010014 Osteolysis Paclitaxel 4.7715867366
MESH:D010024 Osteoporosis Curcumin 3.3418719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0219495926
MESH:D010051 Ovarian Neoplasms Arsenic 26.0017306315
MESH:D010051 Ovarian Neoplasms Curcumin 26.0018462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 26.0019331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 26.0019401270
MESH:D010051 Ovarian Neoplasms Mifepristone 26.0016525653
MESH:D010051 Ovarian Neoplasms Paclitaxel 26.0011161223
MESH:D010051 Ovarian Neoplasms Quercetin 26.0019005980
MESH:D010051 Ovarian Neoplasms trichostatin A 26.0019331143
MESH:D010190 Pancreatic Neoplasms Curcumin 15.5417440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 15.5419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.5416540662
MESH:D010190 Pancreatic Neoplasms Quercetin 15.5416965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 15.5419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.8812065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.786392382 15371236 16905509
MESH:D010954 Plasmacytoma Selenium 4.6815087411
MESH:D011141 Polyuria Lithium Chloride 5.7919692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.642563599
MESH:D011230 Precancerous Conditions Quercetin 8.6419056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.0111222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.0120603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.0118042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 11.7317616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.7317616702
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0716140617
MESH:D011471 Prostatic Neoplasms Curcumin 2.0715129424 11398177 18226269 18156803 18769126 12497104 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0717172428 16356831 16729912 17136230
MESH:D011471 Prostatic Neoplasms Quercetin 2.0717292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0719789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Arsenic 3.8121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.3311422049 12752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.3419168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8310666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.3219155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.3219155313
MESH:D012509 Sarcoma Curcumin 3.9318462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.3316862918
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4818551238
MESH:D012640 Seizures Valproic Acid 5.4811044598 16876388 3137016 11738929 15475178 17978042 1511512 14763951
MESH:D018805 Sepsis Curcumin 3.9018389075
MESH:D012871 Skin Diseases Arsenic 2.696392382 19834688 16759981 18709164 16702368 17548696 17453740 17050553 15952646 17938729 16353154
MESH:D012878 Skin Neoplasms Arsenic 12.7916251483 15504454 17976673 19538983 17029826 17050553
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.7912065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.798532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013274 Stomach Neoplasms decitabine 3.3719037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3718456281
MESH:D013274 Stomach Neoplasms Paclitaxel 3.3718396642 18506536
MESH:D013276 Stomach Ulcer Curcumin 3.3119188055 16631530
MESH:D024801 Tauopathies Paclitaxel 4.6016930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms decitabine 6.7617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.767505956
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 18.8216049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 18.8219322015 17306315 11144890 19429237 17976673 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms Curcumin 18.8218593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.8217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.8216720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.8217572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.0518462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms decitabine 4.7017785578
MESH:D014652 Vascular Diseases Arsenic 4.5217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
Pathway ID Pathway Name
REACT:20676 Cell junction organization
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26284
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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