AutismKB 2.0

Annotation Detail for ARPC5


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Basic Information Top
Gene Symbol:ARPC5 ( ARC16,MGC88523,dJ127C7.3,p16-Arc )
Gene Full Name: actin related protein 2/3 complex, subunit 5, 16kDa
Band: 1q25.3
Quick LinksEntrez ID:10092; OMIM: 604227; Uniprot ID:ARPC5_HUMAN; ENSEMBL ID: ENSG00000162704; HGNC ID: 708
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
200190RAC1 signaling pathway
200057CDC42 signaling events
Pathway IDPathway Name
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARPC5 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARPC5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARPC5 mRNAincreases expression 17557909
C010327 salinomycin salinomycin results in decreased expression of ARPC5 mRNAdecreases expression 19682730
C017947 sodium arsenite sodium arsenite results in increased expression of ARPC5 mRNAincreases expression 20308225
D014635 Valproic Acid Valproic Acid results in increased expression of ARPC5 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5116712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618316065 18985861 20603192 19460635 15238991 18396377 17507914 16609825 17688650 18775368 17157402 18558336 19232924 18177632 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D001943 Breast Neoplasms salinomycin 3.3219682730
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0317306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2219524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1316105132 11677210 16919318 17110522 15861022 17681005 17333356
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0719739265 16781746 11287661 10663392 16177239 11743745 17906064 11739529 11421492 18071297 19085960 18713872 15968718 11461765 17522070 19370779 10915739 17562736 19164858 12705907 15619225 10774834 12594235 12153990 19923254 19416960 16227642 14550746 14986274 12540782 19420014 11529661 11834606 14725611 16081117 12958197 16109766 16485898 2444490 16393943 12392966
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.0719641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.0115345470
MESH:D005234 Fatty Liver Valproic Acid 9.0119224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5718558336 8888407
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.4017937319
MESH:D007248 Infertility, Male sodium arsenite 7.4015346721 12646999
MESH:D007674 Kidney Diseases Acetaminophen 6.5812587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.5820008137
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 12969438 12587719 16611625 11587558 19014921 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms sodium arsenite 2.4716712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms sodium arsenite 1.9019931552 15276417 16712894 17306315 17077188
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.9719682730
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009369 Neoplasms sodium arsenite 2.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009436 Neural Tube Defects sodium arsenite 8.0712854658
MESH:D009436 Neural Tube Defects Valproic Acid 8.078888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5215276417 17306315
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 5.1511422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9616876388 15475178 11738929 1511512 11044598 3137016 17978042 14763951
MESH:D012878 Skin Neoplasms sodium arsenite 2.8418572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D016135 Spinal Dysraphism sodium arsenite 10.4712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 10.4719490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6211723127 17306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25003
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB08235 - N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
    DB08236 - (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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