Gene Symbol:	ARPC5 ( ARC16,MGC88523,dJ127C7.3,p16-Arc )
Gene Full Name:	actin related protein 2/3 complex, subunit 5, 16kDa
Band:	1q25.3
Quick Links	Entrez ID:10092; OMIM: 604227; Uniprot ID:ARPC5_HUMAN; ENSEMBL ID: ENSG00000162704; HGNC ID: 708
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa05131	Shigellosis
hsa05130	Pathogenic Escherichia coli infection
hsa05100	Bacterial invasion of epithelial cells
hsa04810	Regulation of actin cytoskeleton
hsa04666	Fc gamma R-mediated phagocytosis

Pathway ID	Pathway Name
200113	ErbB1 downstream signaling
200190	RAC1 signaling pathway
200057	CDC42 signaling events

Pathway ID	Pathway Name
P00029	Huntington disease
P00016	Cytoskeletal regulation by Rho GTPase
P00034	Integrin signalling pathway
P00031	Inflammation mediated by chemokine and cytokine signaling pathway

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000082	Acetaminophen	Acetaminophen affects the expression of ARPC5 mRNA	affects expression	17562736
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ARPC5 mRNA	increases expression	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ARPC5 mRNA	increases expression	17557909
C010327	salinomycin	salinomycin results in decreased expression of ARPC5 mRNA	decreases expression	19682730
C017947	sodium arsenite	sodium arsenite results in increased expression of ARPC5 mRNA	increases expression	20308225
D014635	Valproic Acid	Valproic Acid results in increased expression of ARPC5 mRNA	increases expression	19101580

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Valproic Acid	4.02	8875741
MESH:D000015	Abnormalities, Multiple	Valproic Acid	4.30	19490988
MESH:D000152	Acne Vulgaris	Ethinyl Estradiol	4.55	17505938
MESH:D000230	Adenocarcinoma	Ethinyl Estradiol	1.88	14692618
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	5.31	15276417
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	5.51	16712894 17306315
MESH:D000550	Amblyopia	Valproic Acid	5.85	17688650
MESH:D000799	Angioedema	Acetaminophen	4.45	10982225
MESH:D001008	Anxiety Disorders	Valproic Acid	3.86	17497229
MESH:D001161	Arteriosclerosis	Ethinyl Estradiol	3.95	11256880
MESH:D001169	Arthritis, Experimental	Ethinyl Estradiol	2.86	15885639
MESH:D001321	Autistic Disorder	Acetaminophen	1.86	18445737
MESH:D001321	Autistic Disorder	Valproic Acid	1.86	18316065 18985861 20603192 19460635 15238991 18396377 17507914 16609825 17688650 18775368 17157402 18558336 19232924 18177632 18940202
MESH:D001714	Bipolar Disorder	Valproic Acid	3.23	20046352 17594078
MESH:D001848	Bone Diseases, Developmental	Valproic Acid	3.61	8888407
MESH:D001943	Breast Neoplasms	salinomycin	3.32	19682730
MESH:D006528	Carcinoma, Hepatocellular	Acetaminophen	3.03	3084413
MESH:D006528	Carcinoma, Hepatocellular	sodium arsenite	3.03	17306315 15276417 16507464
MESH:D002294	Carcinoma, Squamous Cell	sodium arsenite	2.46	18572023
MESH:D002386	Cataract	Acetaminophen	2.77	10977129
MESH:D002471	Cell Transformation, Neoplastic	sodium arsenite	3.22	19524636 20056578
MESH:D002659	Child Development Disorders, Pervasive	Valproic Acid	2.81	20734317
MESH:D002779	Cholestasis	Ethinyl Estradiol	3.13	16105132 11677210 16919318 17110522 15861022 17681005 17333356
MESH:D019465	Craniofacial Abnormalities	Valproic Acid	1.90	16575769 17688650 8888407
MESH:D056486	Drug-Induced Liver Injury	Acetaminophen	4.07	19739265 16781746 11287661 10663392 16177239 11743745 17906064 11739529 11421492 18071297 19085960 18713872 15968718 11461765 17522070 19370779 10915739 17562736 19164858 12705907 15619225 10774834 12594235 12153990 19923254 19416960 16227642 14550746 14986274 12540782 19420014 11529661 11834606 14725611 16081117 12958197 16109766 16485898 2444490 16393943 12392966
MESH:D056486	Drug-Induced Liver Injury	Valproic Acid	4.07	19641884 1733752
MESH:D056487	Drug-Induced Liver Injury, Chronic	Acetaminophen	4.71	19426721
MESH:D004421	Dystonia	Valproic Acid	4.45	1851702
MESH:D004681	Encephalomyelitis, Autoimmune, Experimental	Ethinyl Estradiol	3.63	12538720
MESH:D004831	Epilepsies, Myoclonic	Valproic Acid	4.64	17275665 3659116
MESH:D004828	Epilepsies, Partial	Valproic Acid	4.53	3922381 16628512
MESH:D004827	Epilepsy	Valproic Acid	3.09	20417680 18234410
MESH:D004832	Epilepsy, Absence	Valproic Acid	3.91	6426943 7562514 6254150
MESH:D017029	Epilepsy, Complex Partial	Valproic Acid	4.78	7750514
MESH:D004830	Epilepsy, Tonic-Clonic	Valproic Acid	4.60	3659116
MESH:D005234	Fatty Liver	Ethinyl Estradiol	9.01	15345470
MESH:D005234	Fatty Liver	Valproic Acid	9.01	19224547 14986274
MESH:D005315	Fetal Diseases	Valproic Acid	5.50	16575769
MESH:D005317	Fetal Growth Retardation	Valproic Acid	4.57	18558336 8888407
MESH:D005756	Gastritis	Acetaminophen	4.29	16983495
MESH:D005833	Genital Neoplasms, Female	sodium arsenite	5.22	16452187
MESH:D006689	Hodgkin Disease	sodium arsenite	3.47	12676792
MESH:D006849	Hydrocephalus	Valproic Acid	5.41	17688650
MESH:D006930	Hyperalgesia	Acetaminophen	2.99	16870215
MESH:D007021	Hypospadias	Ethinyl Estradiol	4.29	16945680 16569931
MESH:D007247	Infertility, Female	Ethinyl Estradiol	3.87	12013081
MESH:D007248	Infertility, Male	Ethinyl Estradiol	7.40	17937319
MESH:D007248	Infertility, Male	sodium arsenite	7.40	15346721 12646999
MESH:D007674	Kidney Diseases	Acetaminophen	6.58	12587719 15629191
MESH:D007674	Kidney Diseases	sodium arsenite	6.58	20008137
MESH:D015470	Leukemia, Myeloid, Acute	Valproic Acid	2.19	16294345 17596541
MESH:D008107	Liver Diseases	Acetaminophen	1.69	19784758 12969438 12587719 16611625 11587558 19014921 19460945 16610002
MESH:D017114	Liver Failure, Acute	Acetaminophen	3.58	17185352 16871587
MESH:D008113	Liver Neoplasms	sodium arsenite	2.47	16712894 15276417
MESH:D008171	Lung Diseases	sodium arsenite	3.40	19095001
MESH:D017563	Lung Diseases, Interstitial	Valproic Acid	4.87	17228818
MESH:D008175	Lung Neoplasms	sodium arsenite	1.90	19931552 15276417 16712894 17306315 17077188
MESH:D008325	Mammary Neoplasms, Experimental	salinomycin	3.97	19682730
MESH:D008545	Melanoma	sodium arsenite	2.07	16487513 19082730
MESH:D008546	Melanoma, Experimental	Acetaminophen	4.05	19513568
MESH:D008881	Migraine Disorders	Valproic Acid	3.44	18765137 18803445
MESH:D009139	Musculoskeletal Abnormalities	Valproic Acid	4.40	8888407
MESH:D009190	Myelodysplastic Syndromes	Valproic Acid	3.33	17596541
MESH:D009369	Neoplasms	sodium arsenite	2.64	11559025
MESH:D009374	Neoplasms, Experimental	sodium arsenite	4.15	20056578
MESH:D009436	Neural Tube Defects	sodium arsenite	8.07	12854658
MESH:D009436	Neural Tube Defects	Valproic Acid	8.07	8888407 16359493
MESH:D019636	Neurodegenerative Diseases	Acetaminophen	3.18	18514411
MESH:D010051	Ovarian Neoplasms	sodium arsenite	2.52	15276417 17306315
MESH:D010146	Pain	Acetaminophen	2.69	16870215
MESH:D016584	Panic Disorder	Ethinyl Estradiol	4.09	11578682
MESH:D011297	Prenatal Exposure Delayed Effects	Valproic Acid	4.37	20603192
MESH:D011471	Prostatic Neoplasms	sodium arsenite	3.24	16039940
MESH:D011537	Pruritus	Ethinyl Estradiol	3.85	15861022 16919318
MESH:D019310	Pseudolymphoma	Valproic Acid	5.15	11422049 12752131
MESH:D012208	Rhabdomyosarcoma	Valproic Acid	4.58	19155313
MESH:D012559	Schizophrenia	Valproic Acid	2.10	15737665 19110320
MESH:D012640	Seizures	Valproic Acid	2.96	16876388 15475178 11738929 1511512 11044598 3137016 17978042 14763951
MESH:D012878	Skin Neoplasms	sodium arsenite	2.84	18572023 19524636
MESH:D013088	Spermatocele	Ethinyl Estradiol	4.55	16709447
MESH:D016135	Spinal Dysraphism	sodium arsenite	10.47	12854658
MESH:D016135	Spinal Dysraphism	Valproic Acid	10.47	19490988
MESH:D013226	Status Epilepticus	Valproic Acid	5.15	12833885
MESH:D019851	Thrombophilia	Ethinyl Estradiol	4.02	11994571
MESH:D013927	Thrombosis	Ethinyl Estradiol	3.48	15669648
MESH:D014178	Translocation, Genetic	Valproic Acid	5.85	17262798
MESH:D020194	Unverricht-Lundborg Syndrome	Valproic Acid	5.06	3119515
MESH:D001749	Urinary Bladder Neoplasms	sodium arsenite	2.62	11723127 17306315 16452187 16712894
MESH:D014564	Urogenital Abnormalities	Valproic Acid	5.13	8888407
MESH:D014581	Urticaria	Acetaminophen	3.38	10982225
MESH:D002583	Uterine Cervical Neoplasms	sodium arsenite	4.11	11813266
MESH:D014594	Uterine Neoplasms	Ethinyl Estradiol	3.74	14692618
MESH:D014652	Vascular Diseases	sodium arsenite	4.96	17056641
MESH:D020246	Venous Thrombosis	Ethinyl Estradiol	3.91	14671159 15869587

Pathway ID	Pathway Name
KEGG:05100	Bacterial invasion of epithelial cells
KEGG:04666	Fc gamma R-mediated phagocytosis
KEGG:05130	Pathogenic Escherichia coli infection
KEGG:04810	Regulation of actin cytoskeleton
KEGG:05131	Shigellosis

Drugbank ID	Action	Drug Name	Description
DB08235	-	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
DB08236	-	(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one

AutismKB 2.0

Annotation Detail for ARPC5

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics