AutismKB 2.0

Annotation Detail for ARPC4


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Basic Information Top
Gene Symbol:ARPC4 ( ARC20,MGC13544,p20-Arc )
Gene Full Name: actin related protein 2/3 complex, subunit 4, 20kDa
Band: 3p25.3
Quick LinksEntrez ID:10093; OMIM: 604226; Uniprot ID:ARPC4_HUMAN; ENSEMBL ID: ENSG00000214021,ENSG00000241553; HGNC ID: 707
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
200190RAC1 signaling pathway
200057CDC42 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C103505 AM 251 AM 251 results in decreased expression of ARPC4 mRNAdecreases expression 16500647
D000638 Amiodarone Amiodarone results in increased expression of ARPC4 mRNAincreases expression 19774075
C015001 arsenite arsenite results in increased expression of ARPC4 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARPC4 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ARPC4 mRNAincreases expression 19150397
D003024 Clozapine Clozapine affects the expression of ARPC4 mRNAaffects expression 14647396
D004958 Estradiol Estradiol results in increased expression of ARPC4 mRNAincreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARPC4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARPC4 mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol results in increased expression of ARPC4 mRNAincreases expression 14647396
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARPC4 mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone Progesterone affects the expression of ARPC4 mRNAaffects expression 17251523
D012643 Selenium Selenium results in increased expression of ARPC4 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARPC4 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in increased expression of ARPC4 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9311752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000380 Agranulocytosis Clozapine 5.1314617031 12649775 16160616
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8520041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.9418651412 19698954
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.6419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315845082 15665606 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.9316675129 18497071 17289903 19861407 12948864 17261762 14630087 17018787
MESH:D001943 Breast Neoplasms Progesterone 1.9316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7716924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9115710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002375 Catalepsy Haloperidol 4.9915215559 1977408
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8815861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 7.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 15668235 8697196 15340226 16354765
MESH:D003072 Cognition Disorders Clozapine 5.0417123785
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D003110 Colonic Neoplasms arsenite 2.5915037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9020210726
MESH:D003704 Dementia Haloperidol 4.6311575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6515331141
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.3415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Clozapine 4.2216402076
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.2517692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0119148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 9.1016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Amiodarone 19.2714986274
MESH:D005234 Fatty Liver arsenite 19.2718296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.2715345470
MESH:D005234 Fatty Liver pirinixic acid 19.2719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis arsenite 9.0618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2616080930
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Amiodarone 14.8615265979
MESH:D006529 Hepatomegaly pirinixic acid 14.8618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 8697196 18606429 15340226 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 3.939751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006948 Hyperkinesis Clozapine 4.9916046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.5918020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Progesterone 5.0715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712200463 12878042
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance Estradiol 7.3116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Estradiol 6.2115618244
MESH:D007674 Kidney Diseases Vitamin E 6.2112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D008064 Lipidoses Amiodarone 8.3417567588 15342952
MESH:D008064 Lipidoses Clozapine 8.3417567588
MESH:D008103 Liver Cirrhosis arsenite 3.4518296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9716169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4220195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.4220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6217391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 7.6412587719
MESH:D008171 Lung Diseases Vitamin E 7.6416863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D008175 Lung Neoplasms arsenite 4.9016809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9018569708 18520028 20135361 20064080 6695378 20869020 20464547 17053015 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1916891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.1911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.1915318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D001523 Mental Disorders Clozapine 8.6416856516
MESH:D001523 Mental Disorders Haloperidol 8.6416856516
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.4619142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009181 Mycoses Amiodarone 5.0017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic arsenite 10.4315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 10.4317289903
MESH:D009421 Nervous System Malformations Estradiol 9.6811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009765 Obesity Clozapine 4.7419142110 18515891
MESH:D009765 Obesity pirinixic acid 4.7420558911
MESH:D010051 Ovarian Neoplasms Estradiol 4.9219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9217393432 16525653
MESH:D010146 Pain AM 251 4.3318987195
MESH:D010190 Pancreatic Neoplasms AM 251 3.8616500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5217292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5216740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5215084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 5.0311575062
MESH:D011618 Psychotic Disorders Clozapine 9.2915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.2911575062
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8711597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012559 Schizophrenia Clozapine 4.1216141801 20452607 19369910 18855531 17123785 17667964 11151749 17726453 20521320 20107430 20521326 20168265 18806925 20580759 11763009
MESH:D012559 Schizophrenia Haloperidol 4.121830565 20107430 19369910 18513383
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3616503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.3718087811
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 10.7519225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.7520210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Amiodarone 12.3819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.3812697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.9319584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D016171 Torsades de Pointes Amiodarone 4.2717467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Clozapine 4.5220564506 16141801 16402076 20107430 20521320 17502770
MESH:D015431 Weight Loss Clozapine 5.1617933447
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB08235 - N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
DB08236 - (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
No data
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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