AutismKB 2.0

Annotation Detail for PREB


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Basic Information Top
Gene Symbol:PREB ( MGC3467,SEC12 )
Gene Full Name: prolactin regulatory element binding
Band: 2p23.3
Quick LinksEntrez ID:10113; OMIM: 606395; Uniprot ID:PREB_HUMAN; ENSEMBL ID: ENSG00000138073; HGNC ID: 9356
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Diabetes pathways
Membrane Trafficking
No data
No data
Pathway IDPathway Name
500009COPII (Coat Protein 2) Mediated Vesicle Transport
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PREB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PREB mRNAaffects expression 21346803
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of PREB mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of PREB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PREB mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PREB mRNAdecreases expression 20127859
D016572 Cyclosporine Cyclosporine results in increased expression of PREB mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of PREB mRNAdecreases expression 17011747
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PREB mRNAincreases expression 17011747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PREB mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PREB mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PREB mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PREB mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8517474063 20146248
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.8517129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.733084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.7315948411 16924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.896135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 13.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9517333356 17110522 16105132 15861022 16919318 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 13.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2619416960 11287661 12153990 17522070 14550746 17562736 19420014 16109766 12540782 16781746 15619225 19085960 18713872 16485898 10774834 19370779 11461765 11421492 10663392 14725611 12392966 16393943 18071297 16227642 11739529 12958197 12705907 16081117 11529661 19923254 11743745 10915739 2444490 19739265 19164858 15968718 12594235 17906064 14986274 16177239 11834606
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5516804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 13.8319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8315345470
MESH:D005234 Fatty Liver pirinixic acid 13.8319236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316611131 16513791 16002989 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6114722030 12960047
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 11.8416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.8416569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.058314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7712371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.7715003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6612969438 12587719 19784758 19460945 16611625 11587558 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.757678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7521137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.7516712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 14.7516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.012876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2220464547 6695378 18520028 20135361 17053015 20869020 20064080 18569708 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2219555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6211141357
MESH:D009369 Neoplasms Diethylstilbestrol 8.6215313581
MESH:D009369 Neoplasms pirinixic acid 8.6217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.1911399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8515687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.2217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2211222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2517136230 15046698 15846301
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.4516002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4516709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.3416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3417053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.3416712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.0215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.0214692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:04141 Protein processing in endoplasmic reticulum
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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