AutismKB 2.0

Annotation Detail for ACTR1B


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Basic Information Top
Gene Symbol:ACTR1B ( ARP1B,CTRN2,PC3 )
Gene Full Name: ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
Band: 2q11.2
Quick LinksEntrez ID:10120; OMIM: 605144; Uniprot ID:ACTY_HUMAN; ENSEMBL ID: ENSG00000115073; HGNC ID: 168
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ACTR1B mRNAaffects expression 17562736
D012643 Selenium Selenium results in increased expression of ACTR1B mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of ACTR1B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.5816050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D003092 Colitis Selenium 4.4317936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1314550746 19739265 12540782 11743745 12153990 16177239 15619225 10915739 12392966 18713872 19420014 19085960 11529661 19416960 10774834 16781746 10663392 11461765 17562736 12705907 16109766 18071297 19923254 11739529 2444490 17906064 16485898 15968718 19164858 14725611 16227642 11287661 17522070 14986274 16393943 19370779 12958197 11834606 12594235 11421492 16081117
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:C538011 Eales disease Vitamin E 5.579068938
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1816080930
MESH:D006333 Heart Failure Selenium 3.3217162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.8414716179
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007251 Influenza, Human Selenium 14.0716624496
MESH:D007251 Influenza, Human Vitamin E 14.0716624496
MESH:D007674 Kidney Diseases Acetaminophen 6.7215629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.7212488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.3716518626
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008107 Liver Diseases Acetaminophen 1.7112587719 12969438 11587558 16611625 16610002 19784758 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008171 Lung Diseases Vitamin E 3.4516863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D008654 Mesothelioma Selenium 2.9315107826
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010954 Plasmacytoma Selenium 5.7615087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D020521 Stroke Vitamin E 3.8816517955
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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