AutismKB 2.0

Annotation Detail for RASGRP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RASGRP1 ( CALDAG-GEFI,CALDAG-GEFII,MGC129998,MGC129999,RASGRP,V,hRasGRP1 )
Gene Full Name: RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Band: 15q14
Quick LinksEntrez ID:10125; OMIM: 603962; Uniprot ID:GRP1_HUMAN; ENSEMBL ID: ENSG00000172575; HGNC ID: 9878
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar disorder
PSYCH
type 1 diabetes
IMMUNE
Desease Name
Type 1 diabetes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of RASGRP1 mRNAincreases expression 19901195
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of RASGRP1 mRNAaffects cotreatment|decreases expression 17093179
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RASGRP1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of RASGRP1 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RASGRP1 mRNAincreases expression 17879257
C006780 bisphenol A bisphenol A affects the expression of RASGRP1 mRNAaffects expression 20170705
D016572 Cyclosporine Cyclosporine results in increased expression of RASGRP1 mRNAincreases expression 20106945
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of RASGRP1 mRNAaffects cotreatment|decreases expression 17093179
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RASGRP1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of RASGRP1 mRNAincreases expression 19619570
19264808
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RASGRP1 mRNAaffects expression 20170705
D006220 Haloperidol Haloperidol results in decreased expression of RASGRP1 mRNAdecreases expression 15860345
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNAaffects cotreatment|increases expression 19059307
D013654 Taurine Taurine results in increased expression of RASGRP1 mRNAincreases expression 16579726
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RASGRP1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RASGRP1 mRNAdecreases expression 19619570
19901195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RASGRP1 mRNAincreases expression 20159946
C025643 vinclozolin vinclozolin affects the expression of RASGRP1 mRNAaffects expression 19015723
D015032 Zinc Zinc affects the expression of RASGRP1 mRNAaffects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8414514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D000169 Acrodermatitis Zinc 5.3917190629 16889938 17202136
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.646695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000419 Albuminuria Raloxifene 4.5817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 4.4715800139
MESH:D000544 Alzheimer Disease Zinc 4.4716580781 17119284 16410023 16325427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.8816916123
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001249 Asthma Zinc 2.9517085522
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1218080171 19368416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D001930 Brain Injuries Raloxifene 11.0816580743
MESH:D001930 Brain Injuries Zinc 11.0817109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9517474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.9517123778
MESH:D001943 Breast Neoplasms Estradiol 2.9517261762 12948864 17289903 18497071 16675129 17018787 19861407 14630087
MESH:D001943 Breast Neoplasms Raloxifene 2.9516912660 17952589 17893378 17049068 17261762 15758505 17440819 15775269 16837676 17595753 17242785 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 2.9519059307 19142967 19066611 18815881 19244106 20390343 16818667 17049068 16873071 19221464 19289846 19189212 19410462 15565566 18984771 20544844 17242785 18629630 18997820 19084267 20005174 17893378 20065188 18855134 16273361 17261762 18425577 19155303 18821012 15668708 18351453 19200415 17440819 21152245 21138602 16202921 19103187 19115204 19487384 19011961 20135344 19288272 11161223 19189210 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.503084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.5016924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7720419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.7716543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.4417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 7.5815775269
MESH:D002318 Cardiovascular Diseases Zinc 7.5816936243
MESH:D002375 Catalepsy Haloperidol 4.9015215559 1977408
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.5218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 7.7219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7217110522 11677210 17333356 16105132 15861022 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 8697196 16354765 15340226 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 2.6619302082
MESH:D003456 Cryptorchidism vinclozolin 4.3214966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8220210726
MESH:D003704 Dementia Haloperidol 4.5611575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D003920 Diabetes Mellitus Zinc 4.1916479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.0416025228
MESH:D003928 Diabetic Nephropathies Estradiol 14.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.9215920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.9219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2912594235 14550746 12392966 11461765 19164858 11287661 19370779 10663392 19923254 14986274 2444490 19739265 17562736 18071297 16393943 15968718 10774834 18713872 11739529 11529661 16081117 17906064 12958197 10915739 16109766 11421492 16485898 17522070 19085960 12153990 19420014 16227642 11743745 11834606 16177239 12540782 15619225 16781746 19416960 14725611 12705907
MESH:D056486 Drug-Induced Liver Injury Taurine 6.299328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004487 Edema Raloxifene 6.7915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.2615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.2619031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 12.4819148513
MESH:D016889 Endometrial Neoplasms Estradiol 12.4811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.4816202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6216530937
MESH:D004938 Esophageal Neoplasms Zinc 4.6216543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 18.6319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.6315345470
MESH:D005234 Fatty Liver Raloxifene 18.6317473493
MESH:D005234 Fatty Liver Tamoxifen 18.6319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Cyclosporine 8.4412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005756 Gastritis Acetaminophen 11.1716983495
MESH:D005756 Gastritis Zinc 11.1717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3016417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006130 Growth Disorders Zinc 3.9517217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4110048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure Zinc 3.5917162251
MESH:D006335 Heart Injuries Zinc 5.7717074742
MESH:D016481 Helicobacter Infections Zinc 4.5117241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.6817276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8812621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006973 Hypertension Cyclosporine 8.5410903974
MESH:D006973 Hypertension Raloxifene 8.5417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6117937319
MESH:D007248 Infertility, Male vinclozolin 6.6116467254
MESH:D007249 Inflammation Tamoxifen 4.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.3916393666
MESH:D007333 Insulin Resistance Estradiol 7.3916393666 16627594
MESH:D007511 Ischemia Zinc 4.6216584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 14.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 14.3418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 14.3415618244
MESH:D007674 Kidney Diseases Zinc 14.3416960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.4016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2712371664
MESH:D007680 Kidney Neoplasms Estradiol 12.2715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.2718625569
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 21441929
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7216417039
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9918564211
MESH:D008106 Liver Cirrhosis, Experimental Taurine 4.9915931870 15893842
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9912878042
MESH:D008107 Liver Diseases Acetaminophen 1.6216610002 12587719 19014921 16611625 19784758 11587558 19460945 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3220195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 7.3216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0912151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0117365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3320464547 18816296 18520028 18569708 17053015 20064080 6695378 20869020 20135361
MESH:D008175 Lung Neoplasms Tamoxifen 3.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.9516891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.9519196722 14580682 19196723 11731420 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.9512773700
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D001523 Mental Disorders Haloperidol 4.0016856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1718303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009101 Multiple Myeloma Raloxifene 3.4216497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2616810080
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1611141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 16.2716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 16.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.2714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D010024 Osteoporosis Raloxifene 3.3819059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2117823083 15579764 15758505 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2119401270
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8810923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011225 Pre-Eclampsia Zinc 4.1617114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.2211896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.2219015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.4920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.4920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8916536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms Zinc 1.8916700911 16517595 16606632 12429649
MESH:D011472 Prostatitis vinclozolin 4.9318629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.9411575062
MESH:D011618 Psychotic Disorders Haloperidol 4.2411575062
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0215814490 17365031 17322281 17975199
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration Zinc 4.1116584753
MESH:D012559 Schizophrenia Haloperidol 2.8019369910 1830565 20107430 18513383
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4419755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6920210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013978 Tibial Fractures Estradiol 13.7119048282
MESH:D013978 Tibial Fractures Raloxifene 13.7119048282
MESH:D014062 Tongue Neoplasms Zinc 4.3816543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3017053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.3017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3017572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:04010 MAPK signaling pathway
REACT:14797 Signaling by GPCR
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34240
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA164925725Toxic liver disease
    PA443886Diabetes Mellitus
    PA443888Diabetes Mellitus, Type 1
    Releated drug ID Related drug Name
    PA452621antineoplastic agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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