AutismKB 2.0

Annotation Detail for TRAP1


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Basic Information Top
Gene Symbol:TRAP1 ( HSP75,HSP90L )
Gene Full Name: TNF receptor-associated protein 1
Band: 16p13.3
Quick LinksEntrez ID:10131; OMIM: 606219; Uniprot ID:TRAP1_HUMAN; ENSEMBL ID: ENSG00000126602; HGNC ID: 16264
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of TRAP1 mRNAincreases expression 16631469
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRAP1 mRNAaffects cotreatment|affects expression 17602206
D002945 Cisplatin Cisplatin results in increased degradation of TRAP1 proteinincreases degradation 17853063
D002945 Cisplatin Cisplatin results in increased expression of TRAP1 mRNAincreases expression 16061661
D002945 Cisplatin diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]decreases expression|decreases reaction 17853063
D002945 Cisplatin TRAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]decreases reaction|increases activity|increases cleavage 17853063
D002945 Cisplatin TRAP1 protein results in decreased susceptibility to Cisplatindecreases response to substance 17853063
C014476 diethyl maleate diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]decreases expression|decreases reaction 17853063
C014476 diethyl maleate TRAP1 protein results in decreased susceptibility to diethyl maleatedecreases response to substance 17853063
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRAP1 mRNAaffects cotreatment|affects expression 17602206
D004317 Doxorubicin Doxorubicin results in increased expression of TRAP1 mRNAincreases expression 17680992
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRAP1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of TRAP1 mRNA]affects reaction|decreases expression 15016801
D006861 Hydrogen Peroxide TRAP1 protein results in decreased susceptibility to Hydrogen Peroxidedecreases response to substance 17853063
C006253 pirinixic acid pirinixic acid results in increased expression of TRAP1 mRNAincreases expression 18301758
C009277 sodium arsenate sodium arsenate results in increased expression of TRAP1 mRNAincreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of TRAP1 mRNAdecreases expression 12377979
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TRAP1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRAP1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TRAP1 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D058186 Acute Kidney Injury Cisplatin 4.0412690470 15814532 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Cisplatin 10.3911798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 10.3917418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.3914692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.3917638652
MESH:D000236 Adenoma Diethylnitrosamine 2.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.9918056438 16434500 17620307 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0417306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000740 Anemia Fluorouracil 8.9417963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 12.5114601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 12.5114601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms Cisplatin 2.3718382427 19526202
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3717474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.3711325840 15634643 19526202 15993339 15668708 15994142 17369602 15136595 18234424 15692762 16115903 16595493 17983394 15567936 17426702 18382427 16322301 18695136 18628466 15939500 16826403 16935488 16096432 16264153
MESH:D001943 Breast Neoplasms Fluorouracil 2.3716110121 15136595 18357371 16557594 18608205 19217205 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D002276 Carcinoid Tumor Doxorubicin 12.8116051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.8116051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 9.0317982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0317761372 16502159 20524982 18665156 20084675 20101231 19394651 20514400 16935385 18494052 17055752 18691550 20214788 16878318 16288022 16328049 3084413 19418558 3581430 10737359 19171122 18056438 11831363 18788625 17978847 18971187 21159647 16830150 18210153 16698587 19919837 16681979 16807293 19107877 19822196 20432363 19539802 19383236 19519916 17162532 17173139 18978308 16569478 16540662 20727157 20512989 18393292 19208518 20007298 18506893 19052882 17138121 10672840 19701751 20935162 16779866 17428255 19335982 18785209
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.0316023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0317045692 17971768 16799960 17088986 16332177 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.0315276417 16507464 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0616685392 12023789
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.791485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7918695887
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 11.046189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 11.046189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 11.0418986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 11.0418572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5817351982 16455267 15505089 17007740 17382496 17329180 16731534 17924179 18627295 15811867 16109756 16278810 16269455 16364871 16651473 17131338 16952015 17308081 16612575 17928571 16242529 17519947 17974986 15476868 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9716243910 17334414
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5716936243
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.962727394 21159647 7505956 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9619524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9411677210 15861022 16919318 17110522 16105132 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 12621046 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417287894 17169374 16340194 17016597 17172411 15001691 18772588 17018589 16510598 17725105
MESH:D015179 Colorectal Neoplasms Cisplatin 3.5815273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5818259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5820501625 17594712 18288408 14970324 16391804 17094418 18448328 17695437 17401013 18802399 15289873 17255274 16524972 16303861 16282729 18509181 18949393 17454858 15148649 17016601 16331619 18383874
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8010048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2319107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.2317416283
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 9.2318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2320420201
MESH:D004362 Drug Toxicity Cisplatin 14.1315033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Doxorubicin 14.1318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.1311462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5017359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms Cisplatin 4.8316785472 16481741 17638652 15173087 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.8316481741 16785472 16337965 17638652 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.5315345470
MESH:D005234 Fatty Liver pirinixic acid 13.5320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005909 Glioblastoma Doxorubicin 3.4017150277
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D018149 Glucose Intolerance sodium arsenate 5.1719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 13.3715464296 15102660
MESH:D006258 Head and Neck Neoplasms Doxorubicin 13.3715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 13.3715162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4915464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.5412587719 16244372 16330681 17875725 16707910 16495754 16144979 18006777 18674790 17888722 14766674 16244371 16879835
MESH:D006333 Heart Failure Doxorubicin 7.2117481944
MESH:D006333 Heart Failure pirinixic acid 7.2120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cisplatin 12.7716200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 12.7718501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 12.7712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 8697196 18606429 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8217937319
MESH:D007248 Infertility, Male sodium arsenite 6.8215346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 5.0318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2715464296
MESH:D007674 Kidney Diseases Cisplatin 10.5112231392 15190930 12649298 18289764 19839026
MESH:D007674 Kidney Diseases Doxorubicin 10.5116775033 15699352 15369732
MESH:D007674 Kidney Diseases sodium arsenite 10.5120008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.4016707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 10.4016518626
MESH:D007680 Kidney Neoplasms Fluorouracil 3.3716985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9311231351
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8720032147 18522880 18665156 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms Clofibric Acid 18.3817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.3819642983 19812893 19996281 18754104 21071580 16942905 19850985 21047994 21167192 9163691 2422723 19294768 20583210 12771043 19551842 20405173 19090486 18644402 20501860 18977376 20118626 12112319 20434301 10737359 2862719 18648771 18978307 20101389 19255062 19427195 15885732 19833225 21278145 19499222 20452335 19254457 19073162 19426721 19690152 15175105 20492335 19638242 19256749 20137499
MESH:D008113 Liver Neoplasms Fluorouracil 18.3816603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 18.3816377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 18.3816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.3816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1419519916 18253720 18308698 18544905 19009564 18775883 17854601 19126423 16267830 17942915 21159647 18093689 16842330 18164116 19004024 18079962 19539802 3124819 2563599 17174075 9362446 18282651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.1417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1412151625
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms Cisplatin 8.696189445 17225452 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.6920970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 8.6917418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 8.6915246190
MESH:D008175 Lung Neoplasms sodium arsenite 8.6919931552 17077188 16712894 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.6911884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0815458769
MESH:D008545 Melanoma Cisplatin 5.3012393984 16248763 15577323 17023156 16432458 18176117 18505091 18332650 16809738 12883367 17761969 11135225 12374674
MESH:D008545 Melanoma Doxorubicin 5.3016827129
MESH:D008545 Melanoma sodium arsenite 5.3016487513 19082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8915990972
MESH:D008654 Mesothelioma Cisplatin 6.5517638057
MESH:D008654 Mesothelioma Doxorubicin 6.5517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6916757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.9418186108
MESH:D009203 Myocardial Infarction Doxorubicin 5.8119429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.8119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.983581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9818259882
MESH:D009369 Neoplasms Cisplatin 12.2216773208
MESH:D009369 Neoplasms Fluorouracil 12.2218239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 12.2217405874
MESH:D009369 Neoplasms sodium arsenite 12.2211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6315464296
MESH:D009401 Nephrosis Doxorubicin 4.8716899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0716889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects sodium arsenate 7.8211749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 7.8212854658
MESH:D009447 Neuroblastoma Cisplatin 7.278761367
MESH:D009447 Neuroblastoma Doxorubicin 7.2715555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.818761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010051 Ovarian Neoplasms Cisplatin 5.1617225452 6897625 15464296 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1615276417 17306315
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.8619003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.8616540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8615113037 19003803 16500647 16929163
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.1912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4015464296
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Cisplatin 14.3917638057
MESH:D010997 Pleural Neoplasms Doxorubicin 14.3917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6316729912 15897917 16888761 15749863 18437689 16868541
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6318626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6316039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0815538739 18286688 16160472 18722050
MESH:D051437 Renal Insufficiency Cisplatin 10.7315464296
MESH:D051437 Renal Insufficiency Doxorubicin 10.7317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012509 Sarcoma Doxorubicin 4.0616767912 15675481 15625365 18313854 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.7714601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.7716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012878 Skin Neoplasms Doxorubicin 13.9015692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.9012065085
MESH:D012878 Skin Neoplasms sodium arsenite 13.9018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.9016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4815464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6716767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms Cisplatin 3.5015958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5019015929 17172411 18567086 16424979 16951190 15786421 18396642 17498489 17522103 19084572
MESH:D013736 Testicular Neoplasms Cisplatin 4.7215464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.507505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.5016010429 17909728
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.6412973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.6417653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.6416712894 17306315 11723127 16452187
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 16.3916803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 16.3916803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.3911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7115577323
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317334414 17638931 16364871 17678736
MESH:D014839 Vomiting Cisplatin 4.8511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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