AutismKB 2.0

Annotation Detail for CDH16


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Basic Information Top
Gene Symbol:CDH16 ( - )
Gene Full Name: cadherin 16, KSP-cadherin
Band: 16q22.1
Quick LinksEntrez ID:1014; OMIM: 603118; Uniprot ID:CAD16_HUMAN; ENSEMBL ID: ENSG00000166589; HGNC ID: 1755
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of CDH16 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CDH16 mRNAincreases expression 20064835
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH16 mRNAaffects cotreatment|increases expression 17942748
C029424 hydrazine hydrazine results in increased expression of CDH16 mRNAincreases expression 15282401
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH16 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9412569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D050197 Atherosclerosis Arsenic 3.4412928151 19371607
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8620146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3116507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9917687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9920419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.6819152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6416973168 18022660
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1316105132 17110522 11677210 17333356 17681005 15861022 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2212621046 8697196 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616959395 18606429 16354765 15340226 8697196
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 5.6016076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6018670907 18850075
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007642 Keratosis Arsenic 5.5316930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 8.0816368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0820195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Arsenic 3.5819168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5820064080 20135361 20869020 18520028 18569708 6695378 18816296 20464547 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5819555203 11884234
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D017202 Myocardial Ischemia Arsenic 9.9815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.9812213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects Arsenic 3.6716620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8317306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5316905509 6392382 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Arsenic 3.2316140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2317292933
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012871 Skin Diseases Arsenic 2.8217548696 17453740 17050553 17938729 15952646 16759981 18709164 19834688 16353154 16702368 6392382
MESH:D012878 Skin Neoplasms Arsenic 10.2816251483 17029826 17050553 19538983 17976673 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.2810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.2816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5511144890 18640142 17306315 19429237 19322015 17976673 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5517053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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