AutismKB 2.0

Annotation Detail for GPR64


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Basic Information Top
Gene Symbol:GPR64 ( EDDM6,FLJ00282,HE6,MGC104454,MGC138738,MGC138739,TM7LN2 )
Gene Full Name: G protein-coupled receptor 64
Band: Xp22.13
Quick LinksEntrez ID:10149; OMIM: 300572; Uniprot ID:GPR64_HUMAN; ENSEMBL ID: ENSG00000173698; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPR64 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GPR64 mRNAdecreases expression 17879257
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GPR64 mRNAincreases expression 20064835
D016572 Cyclosporine Cyclosporine results in increased expression of GPR64 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of GPR64 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPR64 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of GPR64 mRNAdecreases expression 20360939
C041786 palm oil palm oil results in decreased expression of GPR64 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GPR64 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GPR64 mRNAincreases expression 19482888
D043343 Testosterone Propionate Testosterone Propionate results in increased expression of GPR64 mRNAincreases expression 15601916
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.966695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.9619389873
MESH:D000236 Adenoma Diethylnitrosamine 11.9610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4318056438 19052882 16434500 19061943 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4317620307
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1418788625 19335982 20514400 20101231 17173139 19519916 16288022 16935385 10672840 20524982 20727157 20214788 19539802 20084675 16502159 18056438 17978847 18978308 16569478 19822196 18506893 17428255 19171122 20432363 16328049 19383236 17138121 16807293 19208518 3581430 17761372 11831363 16878318 18494052 19919837 16681979 17055752 19107877 18210153 17162532 19052882 21159647 19701751 18691550 18785209 16830150 18393292 16779866 3084413 10737359 20007298 20935162 16540662 18665156 20512989 19394651 18971187 19418558 16698587
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1417173139 20935162 20007298 6705139 1701930
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.142727394 21159647 17174075 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1119107877
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Cyclosporine 14.5719224547
MESH:D005234 Fatty Liver Dietary Fats 14.5717967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 14.5720387270 21071580
MESH:D005355 Fibrosis Cyclosporine 9.7312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.7318296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Phenobarbital 3.7916109766
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation Dietary Fats 5.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.4818785209
MESH:D007333 Insulin Resistance Dietary Fats 3.2511836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008103 Liver Cirrhosis Dietary Fats 11.7318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.7318665156 19638242 20032147 18407596 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 11.7321047994
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2817034775
MESH:D008107 Liver Diseases Phenobarbital 4.2819363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4021137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.4019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.4018648771 15885732 20137499 18978307 12771043 19090486 21278145 20118626 20452335 20583210 12112319 16942905 15175105 20434301 19690152 9163691 19638242 20492335 20101389 20405173 19812893 19294768 19499222 19996281 18977376 2862719 19254457 19256749 21047994 19255062 18644402 19551842 18754104 19833225 19426721 20501860 21071580 2422723 19427195 10737359 19850985 19073162 21167192 19642983
MESH:D008113 Liver Neoplasms Phenobarbital 11.4019812893 21047994 8742319 19073162 15975961 19482888
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.7718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7716842330 3124819 18164116 16267830 21159647 18775883 19126423 18079962 17854601 18544905 2563599 19009564 18253720 19539802 19004024 17174075 17942915 18308698 9362446 18093689 18282651 19519916
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.772563599 17172636 6150874 1399818 18308698
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320464547 20064080 18816296 20135361 20869020 6695378 18569708 18520028 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.436695378 21163286 20512841 20970405
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity Dietary Fats 2.3319632207 17217161 18674790 21332399 20132043 20518802 18457598 16723640 11836018
MESH:D010003 Osteoarthritis marker/mechanism 17568789
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5116965848
MESH:D011230 Precancerous Conditions Cyclosporine 16.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.562563599
MESH:D011230 Precancerous Conditions Phenobarbital 16.562563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012640 Seizures Phenobarbital 2.843137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3818456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.797505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.791399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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