AutismKB 2.0

Annotation Detail for ABI2


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Basic Information Top
Gene Symbol:ABI2 ( ABI-2,ABI2B,AIP-1,AblBP3,SSH3BP2,argBPIA,argBPIB )
Gene Full Name: abl-interactor 2
Band: 2q33.2
Quick LinksEntrez ID:10152; OMIM: 606442; Uniprot ID:ABI2_HUMAN; ENSEMBL ID: ENSG00000138443; HGNC ID: 24011
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1864Fibroid tumor
2237Neoplasm metastasis
Desease Name
CARDIOVASCULAR
subclinical atherosclerosis traits (other)
Desease Name
Subclinical atherosclerosis traits (other)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABI2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ABI2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ABI2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABI2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABI2 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABI2 mRNAdecreases expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ABI2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ABI2 mRNAdecreases expression 17557909
D008345 Manganese Manganese results in increased expression of ABI2 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of ABI2 mRNAincreases expression 17175027
D010100 Oxygen Oxygen deficiency results in increased expression of ABI2 mRNAincreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury Oxygen 4.7216759491
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D000756 Anemia, Sideroblastic Manganese 11.6116910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.6116910769
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D000860 Anoxia Oxygen 5.2920872349
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D050197 Atherosclerosis Oxygen 3.9016391483
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001943 Breast Neoplasms Oxygen 3.2117263869
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915673190 16011737 16050911 16124888 15721981 16097048 16192424 10355542 15700767 3786805 16227642 18705752
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7418788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2819486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2817681005 15861022 16919318 17110522 16105132 17333356 11677210
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111906362 11298694 14531868 18759878 2524372 12868966 8156756 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.349022650 11289319 18692083 18648102 6482804 1440618 8291058 7440962 9653073 6679447 18289764 16192314 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3412540782 14725611 11529661 16081117 12594235 16781746 19923254 17906064 16393943 12705907 10663392 19416960 2444490 19739265 17562736 11743745 19370779 11461765 16485898 10915739 14550746 11739529 19164858 18071297 12153990 11287661 12392966 18713872 15619225 19420014 11421492 11834606 16227642 15968718 16177239 14986274 19085960 12958197 16109766 17522070 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3415968718 21278145 7440962 10915739 4309450 10092053 11566570 2869522 19085960 15027814 16227642 7179309 9327722 6884620 19336974 3732212 16177239 7120509 17522070 6623471 15998439 3786805
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004417 Dyspnea Oxygen 5.1020016425
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2712795759 15959796 12631006 16239168 19224547 16045604 61145 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D005739 Gas Poisoning Oxygen 5.4820016425
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Manganese 4.0217043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917157831 16221502 16943688 16239168 17174718 11903743 11408273 21278145 17334410
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518472332 18156304 17708605 18418968 14716496 13678700 14620537 18412020 18006644 15057751 15818738 15996030 17761835 15730626 15925388 12445421 17698563 17721639 14748882 12741479 12389079 12546737 16015684 18187930 12666154 17525996 17823541 17557913 18277467 18279442 15370692 17944888 17714472 15673190 18251166 15362042 18376398 12632514 18481824 16248980 17976157 18339082 14512876 15876570 20821823 16027843 15052691 10355542 16638106 12667390 17869086 12958196 18166357 12898905 12609069 18210741 18263696 12632512 16136751 16192424 14724832 16116963 12445418 17565644 17922224 18205269 15959796 17805973 18054572 15123356 16011737 18705752 11481614 15338365 14716833 17640975 16033810 12586293 17481882 18429990 12649538 17766677 17900296 17631135 15893842 18317297 18472094 18395914 18395095 16097048 15650968 15931870 18420326
MESH:D008107 Liver Diseases Acetaminophen 4.0311587558 12969438 19784758 16611625 19014921 16610002 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0315830285 16964402 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2719294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.25598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2512014681 15583823
MESH:D055370 Lung Injury Oxygen 4.7218339021
MESH:D020149 Manganese Poisoning Manganese 5.7919453300 16551646 16568477
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009069 Movement Disorders Manganese 5.1916551646
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009410 Nerve Degeneration Manganese 4.4016551646
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010300 Parkinson Disease Manganese 3.4211181820
MESH:D020734 Parkinsonian Disorders Manganese 4.6316140633
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.6917627322 18339021
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013398 Sudden Infant Death Oxygen 5.7812563064
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.011399818 6582329 3712494 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.218074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134977642
    • No data
    Releated disease ID Related disease Name
    PA443425Arteriosclerosis
    PA443635Cardiovascular Diseases
    PA443797Coronary Disease
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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