AutismKB 2.0

Annotation Detail for RASA4


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Basic Information Top
Gene Symbol:RASA4 ( CAPRI,FLJ59070,GAPL,KIAA0538,MGC131890,RASA4B )
Gene Full Name: RAS p21 protein activator 4
Band: 7q22.1
Quick LinksEntrez ID:10156; OMIM: 607943; Uniprot ID:RASL2_HUMAN; ENSEMBL ID: ENSG00000105808; HGNC ID: 23181
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RASA4 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of RASA4 mRNAincreases expression 15003993
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RASA4 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of RASA4 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RASA4 mRNAaffects expression 17555576
D019833 Genistein Genistein results in increased expression of RASA4 mRNAincreases expression 15289156
D013629 Tamoxifen Tamoxifen affects the expression of RASA4 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Estradiol 7.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4114692618
MESH:D000230 Adenocarcinoma Genistein 7.4111473722
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.0218497071 12948864 16675129 14630087 17289903 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms Genistein 2.0216873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tamoxifen 2.0211161223 16202921 19155303 18351453 19189212 17242785 19410462 20859285 19115204 16818667 20135344 19244106 19011961 17049068 15668708 19487384 19189210 18984771 18815881 19066611 17261762 20065188 21138602 18425577 19288272 18821012 18629630 18997820 19221464 18855134 19084267 21152245 15565566 16873071 20390343 19103187 20544844 16273361 17893378 19200415 19289846 17440819 20005174 19142967 19059307
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.273084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 9.2716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.2716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.2716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.2716924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0711677210 17333356 16105132 15861022 16919318 17110522 17681005
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8916002989 12952375
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D003928 Diabetic Nephropathies Estradiol 9.6819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6511739529 11287661 2444490 17522070 16081117 16781746 12153990 18071297 17562736 12540782 19420014 12958197 15968718 14550746 18713872 16227642 19164858 11461765 19370779 10915739 16393943 14725611 10774834 19416960 14986274 19739265 12392966 17906064 19085960 11421492 15619225 11529661 16485898 12705907 12594235 11834606 16109766 16177239 10663392 11743745 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 13.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 13.2516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 19.2316804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 19.2319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 19.2311473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 19.2319155303 17893378 16202921 20544844
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.7216534752 16611131 15751030 16513791 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.7216709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7912960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 6.3712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.8716762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 13.8715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 13.8718625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D007938 Leukemia Genistein 3.1417468513 18980019
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6817823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6818564211
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 19014921 11587558 19784758 12587719 19460945 16611625 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Diethylstilbestrol 5.0316712894 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 5.0316684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.9711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.9714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.9711731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2317141266
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Diethylstilbestrol 2.8815313581
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.5011399458
MESH:D009421 Nervous System Malformations Estradiol 18.5016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 18.5016427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1419005980
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0316977796 15687265
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5117184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0615846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0615256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D013088 Spermatocele Diethylstilbestrol 22.9216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 22.9216709447
MESH:D013088 Spermatocele Tamoxifen 22.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.5216452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5216712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916002989 16513791
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
KEGG:03020 RNA polymerase
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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