AutismKB 2.0

Annotation Detail for CDH18


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Basic Information Top
Gene Symbol:CDH18 ( CDH14,CDH14L,CDH24 )
Gene Full Name: cadherin 18, type 2
Band: 5p14.3
Quick LinksEntrez ID:1016; OMIM: 603019; Uniprot ID:CAD18_HUMAN; ENSEMBL ID: ENSG00000145526; HGNC ID: 1757
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell junction organization
No data
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A affects the expression of CDH18 mRNAaffects expression 20170705
D016572 Cyclosporine Cyclosporine results in increased expression of CDH18 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of CDH18 mRNAincreases expression 17555868
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDH18 mRNAaffects expression 20170705
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Estradiol 4.4811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001862 Bone Resorption bisphenol A 4.2911985600
MESH:D001943 Breast Neoplasms bisphenol A 2.1817123778
MESH:D001943 Breast Neoplasms Estradiol 2.1817261762 12948864 18497071 16675129 19861407 17289903 14630087 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.6217123778
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4618566989
MESH:D002779 Cholestasis Cyclosporine 8.7619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7616919318 17333356 16105132 17110522 17681005 15861022 11677210
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.2219148513 18566989 11473722
MESH:D005234 Fatty Liver Cyclosporine 9.0219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.0215345470
MESH:D005355 Fibrosis Cyclosporine 3.7012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007333 Insulin Resistance bisphenol A 8.2516393666
MESH:D007333 Insulin Resistance Estradiol 8.2516393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 8.4415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7916891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 11.4811399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 11.4811399458 16427766
MESH:D010049 Ovarian Diseases bisphenol A 5.6211985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.3119401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.5810548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 12.0120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 12.0120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.1916740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.1916740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.9415861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D011629 Puberty, Precocious bisphenol A 5.4210548101
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.6116045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014591 Uterine Diseases bisphenol A 5.7314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
Pathway ID Pathway Name
REACT:20676 Cell junction organization
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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