AutismKB 2.0

Annotation Detail for LPAR6


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Basic Information Top
Gene Symbol:LPAR6 ( ARWH1,LAH3,MGC120358,P2RY5,P2Y5 )
Gene Full Name: lysophosphatidic acid receptor 6
Band: 13q14.2
Quick LinksEntrez ID:10161; OMIM: 609239; Uniprot ID:LPAR6_HUMAN; ENSEMBL ID: ENSG00000139679; HGNC ID: 15520
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500423P2Y receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2230Alopecia
No data
No data
Desease Name
Hypotrichosis, localized, autosomal recessive, 3
Woolly hair, autosomal recessive 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LPAR6 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LPAR6 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of LPAR6 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of LPAR6 mRNAincreases expression 16002434
D005472 Fluorouracil Fluorouracil results in decreased expression of LPAR6 mRNAdecreases expression 17039268
C056507 gemcitabine gemcitabine results in decreased expression of LPAR6 mRNAdecreases expression 17039268
C032881 lysophosphatidic acid lysophosphatidic acid binds to and results in increased activity of LPAR6 proteinaffects binding|increases activity 18297070
C029938 nickel sulfate nickel sulfate results in decreased expression of LPAR6 mRNAdecreases expression 16780908
C041786 palm oil palm oil results in decreased expression of LPAR6 mRNAdecreases expression 18042831
C017947 sodium arsenite sodium arsenite results in decreased expression of LPAR6 mRNAdecreases expression 16014739
C004648 testosterone enanthate testosterone enanthate affects the expression of LPAR6 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 4.4612718980 11954676 16100012 19131640
MESH:D000230 Adenocarcinoma Fluorouracil 2.4517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000740 Anemia Fluorouracil 3.8416511603 15504547 17963324
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001943 Breast Neoplasms Calcitriol 2.0611237771
MESH:D001943 Breast Neoplasms Dietary Fats 2.0620435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.0618608205 19217205 16595493 16110121 15136595 18357371 16557594
MESH:D001943 Breast Neoplasms gemcitabine 2.0618382427 17039268
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.733581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.733084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7317045692 16799960 16332177 18930000 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7317306315 16507464 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.697296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6918695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8311237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.8316757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.8318572023
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.057505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.0520056578 19524636
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.259022650 19486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517172411 15001691 18772588 16510598 17169374 17725105 17018589 16340194 17287894 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 16282729 14970324 17695437 17016601 18509181 15289873 15148649 17094418 17401013 17594712 18383874 16391804 17454858 18288408 16524972 18949393 16303861 18448328 16331619 18802399 20501625
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.738156756 2524372 18759878 11298694 12868966 11906362 14531868 8970840
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.7316823706 16780908 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.836679447 9328219 16192314 18692083 9653073 1440618 9022650 18289764 8291058 6482804 11289319 18648102 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8316485898 16177239 11529661 16227642 16393943 19085960 19420014 15968718 12540782 14986274 12392966 12594235 10663392 17522070 15619225 17906064 2444490 11834606 12705907 12958197 10774834 16109766 17562736 19739265 11739529 11461765 19370779 19164858 18713872 16781746 19923254 19416960 11743745 11421492 18071297 14725611 12153990 16081117 14550746 11287661 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.633581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6317638652 15173087 16481741 16337965 16785472
MESH:D005234 Fatty Liver Dietary Fats 3.3819004024 17967931 19551842 18296743
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Dietary Fats 3.7018296743
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815162350 18337622 15102660
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9617440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
OMIM:611452 HYPOTRICHOSIS, LOCALIZED, AUTOSOMAL RECESSIVE 3 marker/mechanism
OMIM:605389 HYPOTRICHOSIS SIMPLEX, GENERALIZED, HEREDITARY marker/mechanism 18297070
MESH:D007248 Infertility, Male sodium arsenite 3.0812646999 15346721
MESH:D007249 Inflammation Dietary Fats 2.4920412841
MESH:D007333 Insulin Resistance Dietary Fats 3.1911836018 18457598
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.2220008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.876582329
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8716985049
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 16610002 19784758 16611625 19460945 12587719 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 4.8915113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 4.8915276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.61598648 6587162 3712494 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms Fluorouracil 2.6215246190
MESH:D008175 Lung Neoplasms sodium arsenite 2.6216712894 17077188 17306315 19931552 15276417
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7416757204 18986760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Fluorouracil 5.4018600527 18239605 16928823
MESH:D009369 Neoplasms sodium arsenite 5.4011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.556679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.5512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009765 Obesity Dietary Fats 2.3121332399 16723640 20132043 18457598 17217161 19632207 11836018 18674790 20518802
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4715276417 17306315
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.8815113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.8811504793 18383843 16929163 18992248 17440100
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6218247401 16289102 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6219082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6216039940
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1415538739 18286688 18722050 16160472
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012878 Skin Neoplasms sodium arsenite 2.7519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019015929 17522103 19084572 16424979 16951190 18396642 15786421 17498489 18567086 17172411
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.991399818 6587162 7505956 6582329 3712494
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.258074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2511723127 17306315 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.9316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
OMIM:278150 WOOLLY HAIR, AUTOSOMAL RECESSIVE 1 marker/mechanism 18297072
MESH:D014947 Wounds and Injuries lysophosphatidic acid 5.4215541073
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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