AutismKB 2.0

Annotation Detail for WASF2


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Basic Information Top
Gene Symbol:WASF2 ( SCAR2,WAVE2,dJ393P12.2 )
Gene Full Name: WAS protein family, member 2
Band: 1p36.11
Quick LinksEntrez ID:10163; OMIM: 605875; Uniprot ID:WASF2_HUMAN; ENSEMBL ID: ENSG00000158195; HGNC ID: 12733
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
200105E-cadherin signaling in the nascent adherens junction
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2181Liver metastases
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WASF2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of WASF2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of WASF2 mRNAdecreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of WASF2 mRNAaffects expression 17562736
C015001 arsenite arsenite results in increased expression of WASF2 mRNAincreases expression 18191166
D016572 Cyclosporine Cyclosporine results in increased expression of WASF2 mRNAincreases expression 20106945
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of WASF2 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of WASF2 mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in decreased expression of WASF2 mRNAdecreases expression 16788091
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of WASF2 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of WASF2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8116206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.781917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D002386 Cataract Acetaminophen 7.6010977129
MESH:D002386 Cataract Tretinoin 7.6017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Selenium 10.3717936198
MESH:D003092 Colitis Tretinoin 10.3717035595
MESH:D003110 Colonic Neoplasms arsenite 2.6115037631
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7410589399 9125849 8800419 16925845 17551590 9211117 14991402 9142499 9224671 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7419769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4219739265 11421492 11743745 10774834 11529661 17522070 12540782 19370779 11739529 19416960 12153990 16227642 16781746 19164858 10663392 18071297 14550746 11461765 14725611 12594235 18713872 11834606 16393943 15968718 15619225 17906064 16177239 19085960 10915739 16081117 16109766 2444490 12392966 14986274 19420014 19923254 17562736 16485898 12958197 12705907 11287661
MESH:D056486 Drug-Induced Liver Injury Selenium 9.4215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D005124 Eye Abnormalities Tretinoin 3.7316938888 9664655
MESH:D005234 Fatty Liver arsenite 8.6318296743
MESH:D005234 Fatty Liver Cyclosporine 8.6319224547
MESH:D005355 Fibrosis arsenite 16.4418296743
MESH:D005355 Fibrosis Cyclosporine 16.4412639820 12168785
MESH:D005355 Fibrosis Tretinoin 16.4417994277
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 7.1014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 7.1016080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 8.1816870215
MESH:D006930 Hyperalgesia Tretinoin 8.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.6512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.658314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.6512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.3916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.3916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.3912371664
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2819075265 17339181 17301526 17712046 12679006 16788101 19029980 15748426 16935935 17361223 16891316 19035177 17506722 17649720 17294898 16331271 16823087 17107899 19225113 16766008 19642359 17217047 16140955 9834237 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008103 Liver Cirrhosis arsenite 3.5218296743
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6016248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.6016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6711587558 19784758 19460945 16611625 16610002 19014921 12587719 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.666135515 2876784 2876786
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms arsenite 2.7716809336
MESH:D008175 Lung Neoplasms Vitamin E 2.7711062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.3218551238 7678174
MESH:D009369 Neoplasms Tretinoin 2.4916594593 16946489
MESH:D009389 Neovascularization, Pathologic arsenite 4.7015738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Tretinoin 7.1616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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