AutismKB 2.0

Annotation Detail for SLC25A15


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Basic Information Top
Gene Symbol:SLC25A15 ( D13S327,HHH,ORC1,ORNT1 )
Gene Full Name: solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
Band: 13q14.11
Quick LinksEntrez ID:10166; OMIM: 603861; Uniprot ID:ORNT1_HUMAN; ENSEMBL ID: ENSG00000102743; HGNC ID: 10985
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of amino acids and derivatives
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Related Diseases/Disorders Top
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Desease IDDesease Name
1954Stroke
No data
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Desease Name
Hyperornithinemia-hyperammonemia-homocitrullinemia syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC25A15 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of SLC25A15 mRNAaffects expression 18648102
D002220 Carbamazepine Carbamazepine results in increased expression of SLC25A15 mRNAincreases expression 17112801
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC25A15 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNAaffects cotreatment|increases expression 18313992
D010634 Phenobarbital Phenobarbital results in increased expression of SLC25A15 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of SLC25A15 mRNAincreases expression 18445702
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 10.078986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.076195326
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.139612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001714 Bipolar Disorder Carbamazepine 4.2417594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.767296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7617173139 6705139 20007298 20935162 1701930
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.4219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 14.4219486331
MESH:D002779 Cholestasis pirinixic acid 14.4219176532
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.969014606
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1014531868 8970840 11906362 11298694 2524372 12868966 18759878 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.7511748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.5416538175 15057820 16538176 20216337
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.7518692083 6482804 18289764 8291058 9022650 1440618 9328219 7440962 16192314 9653073 6679447 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 6.7517465707
MESH:D004362 Drug Toxicity Carbamazepine 15.1520216337
MESH:D004362 Drug Toxicity Lamivudine 15.1515040536
MESH:D004362 Drug Toxicity Zidovudine 15.1515040536
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 5.0117654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.5416538176 20485159 18855540 16415921 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 12.2317275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 12.233659116
MESH:D004828 Epilepsies, Partial Carbamazepine 11.6517116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenobarbital 11.6511558140 3922381
MESH:D004827 Epilepsy Carbamazepine 7.4219700373 7988514 19439326 18234410 19620853 17465707 20417680 17178248 9014606 821787
MESH:D004827 Epilepsy Phenobarbital 7.4220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 12.737750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.737750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 12.0215276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 12.023659116
MESH:D004916 Erythromelalgia Carbamazepine 6.0619549232
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005076 Exanthema Carbamazepine 5.8020485159
MESH:D005234 Fatty Liver Cyclosporine 14.6019224547
MESH:D005234 Fatty Liver pirinixic acid 14.6019236843 20131406
MESH:D005234 Fatty Liver Zidovudine 14.6018299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006402 Hematologic Diseases Zidovudine 4.9712579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006509 Hepatitis B Lamivudine 5.3417703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.3415309715 15631357 12044531 16476009 15274664
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5219176532 19772884 18467677 16221962
MESH:D015658 HIV Infections Lamivudine 7.4417530837 11141242 9296927 20032539
MESH:D015658 HIV Infections Zidovudine 7.4417358032 11363243 20032539 11141242 11698656
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.9410459572
OMIM:238970 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA SYNDROME marker/mechanism
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 12.1615034207
MESH:D006965 Hyperplasia Carbamazepine 12.1618773962
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.526582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.5212371664
MESH:D007680 Kidney Neoplasms Zidovudine 19.5212579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.6520370541
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.7219812893 8742319 19073162 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 4.7215890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.42598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.421399818 6150874 17172636 2563599 18308698
MESH:D008175 Lung Neoplasms Zidovudine 2.4818800350
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.6216628512
MESH:D008607 Mental Retardation Carbamazepine 3.799014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.2117358032
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.8020399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 5.1916990009
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010018 Osteomalacia Carbamazepine 13.2517016548
MESH:D010018 Osteomalacia Phenobarbital 13.2517016548
MESH:D010146 Pain Carbamazepine 4.2315215642
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010267 Parapsoriasis Carbamazepine 6.0116538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.2617145499 17679678
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Cyclosporine 9.6912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.692563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.469014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 5.229014606
MESH:D019310 Pseudolymphoma Carbamazepine 13.8712752131 9591791
MESH:D019310 Pseudolymphoma Phenobarbital 13.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.879296927
MESH:D012640 Seizures 2,4-dinitrotoluene 10.9218551238
MESH:D012640 Seizures Carbamazepine 10.9216876388 15946322 19414003 16938433 9046859 16180713 9844417
MESH:D012640 Seizures Phenobarbital 10.9211442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012893 Sleep Disorders Carbamazepine 5.4619414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.5216538176 19694795 15057820 16415921 20485159 18855540 19915237
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.763712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.761399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014625 Vaginal Neoplasms Zidovudine 5.0612579204
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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