AutismKB 2.0

Annotation Detail for DHRS9


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Basic Information Top
Gene Symbol:DHRS9 ( 3ALPHA-HSD,RDH15,RDHL,RDHTBE,RETSDR8,SDR9C4 )
Gene Full Name: dehydrogenase/reductase (SDR family) member 9
Band: 2q31.1
Quick LinksEntrez ID:10170; OMIM: 612131; Uniprot ID:DHRS9_HUMAN; ENSEMBL ID: ENSG00000073737; HGNC ID: 16888
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1861Epstein-Barr virus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DHRS9 mRNAaffects cotreatment|increases expression 17093179
C103303 alitretinoin alitretinoin results in increased expression of DHRS9 mRNAincreases expression 11304534
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DHRS9 mRNAaffects expression 16483693
C014347 decitabine decitabine results in increased expression of DHRS9 mRNAincreases expression 19194470
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DHRS9 mRNAaffects cotreatment|increases expression 17093179
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DHRS9 mRNAdecreases expression 16872691
C025299 polyphenols polyphenols results in decreased expression of DHRS9 mRNAdecreases expression 16293270
C089730 rosiglitazone rosiglitazone results in increased expression of DHRS9 mRNAincreases expression 16982809
C024746 tobacco tar tobacco tar results in decreased expression of DHRS9 mRNAdecreases expression 19559774
D014050 Toluene Toluene affects the expression of DHRS9 mRNAaffects expression 18653662
D014212 Tretinoin Tretinoin results in increased expression of DHRS9 mRNAincreases expression 11304534
D014801 Vitamin A DHRS9 protein results in increased metabolism of Vitamin Aincreases metabolic processing 11304534
D014801 Vitamin A DHRS9 protein results in increased oxidation of Vitamin Aincreases oxidation 16982809
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple Vitamin A 4.9710992263
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8719621015
MESH:D000740 Anemia Vitamin A 4.6216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.9016960172
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 5.3216456186
MESH:D001249 Asthma Vitamin A 5.3216732791
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7216197459 16206674
MESH:D001943 Breast Neoplasms alitretinoin 2.0716344269
MESH:D001943 Breast Neoplasms decitabine 2.0719208741 18320071
MESH:D001943 Breast Neoplasms Tretinoin 2.0716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 13.5416813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 13.5417377406 17426644
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.911917145
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8619215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8616096774 16051514
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.0219559774
MESH:D002547 Cerebral Palsy Toluene 6.009294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.6516153327
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5616105132 17681005 16919318 17110522 15861022 11677210 17333356
MESH:D002779 Cholestasis Vitamin A 8.5616175620
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tretinoin 6.489407595
MESH:D002972 Cleft Palate Vitamin A 6.4816054864
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms decitabine 6.1617616700
MESH:D003110 Colonic Neoplasms polyphenols 6.1616293270
MESH:D003110 Colonic Neoplasms Vitamin A 6.1617219422 16267017
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Toluene 4.169294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.1614991402 10589399 9142499 17551590 16925845 9125849 9211117 9664655 9224671 8800419
MESH:D019465 Craniofacial Abnormalities Vitamin A 4.1610992263
MESH:D003643 Death Toluene 5.846431079
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4017446233
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.5416506275
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9612642470
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1011421492 19370779 16081117 10774834 19739265 14550746 11834606 12540782 16109766 12153990 17906064 11529661 14986274 15619225 19164858 2444490 19420014 16393943 16227642 11739529 19085960 12392966 12594235 11743745 11287661 16485898 12958197 19923254 10915739 17562736 15968718 18071297 16177239 16781746 17522070 11461765 18713872 10663392 19416960 14725611 12705907
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.1019370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D015352 Dry Eye Syndromes Vitamin A 5.9616146918
MESH:C538011 Eales disease Vitamin A 5.799068938
MESH:D004480 Ectromelia Vitamin A 6.0016054864
MESH:D004487 Edema rosiglitazone 3.7612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.6418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1816569247
MESH:D005124 Eye Abnormalities Tretinoin 3.6616938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3415345470
MESH:D005234 Fatty Liver rosiglitazone 8.3419196556
MESH:D005327 Fetal Resorption Vitamin A 5.5416054864
MESH:D005355 Fibrosis Tretinoin 3.6517994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006258 Head and Neck Neoplasms decitabine 8.0719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 7.2914991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 7.2910992263 16080930
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.6516490937 16877224 16292552 15707848 17436238 16863852
MESH:D015658 HIV Infections Vitamin A 3.8716960176
MESH:D006679 HIV Seropositivity Vitamin A 5.7517209195
MESH:D006930 Hyperalgesia Acetaminophen 13.6216870215
MESH:D006930 Hyperalgesia rosiglitazone 13.6212083418
MESH:D006930 Hyperalgesia Tretinoin 13.6216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006986 Hypervitaminosis A Vitamin A 6.3416054864
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male decitabine 6.9617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007249 Inflammation polyphenols 5.7916366677
MESH:D007249 Inflammation rosiglitazone 5.7912083418
MESH:D007333 Insulin Resistance rosiglitazone 3.8716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D019586 Intracranial Hypertension Vitamin A 6.0015955940
MESH:D007569 Jaw Abnormalities Tretinoin 4.0117551590 15992940
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7916144296
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007938 Leukemia decitabine 6.6018980019 19235587
MESH:D007938 Leukemia Tretinoin 6.6017143497
MESH:D007951 Leukemia, Myeloid decitabine 9.9318454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 9.9316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0318704418 19010910 19387464 18206229 18460780 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0316294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2216331271 19225113 19035177 17217047 19642359 17368321 9834237 12679006 16788101 16140955 15748426 17506722 17107899 19029980 16823087 17649720 19075265 17301526 17712046 16935935 17294898 17361223 17339181 16891316 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.769224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.7616054864
MESH:D008103 Liver Cirrhosis Vitamin A 3.9316256175
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.8317347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.8316248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 3.8316248980
MESH:D008107 Liver Diseases Acetaminophen 6.8612969438 16611625 19014921 12587719 19784758 19460945 11587558 16610002
MESH:D008107 Liver Diseases polyphenols 6.8616698588
MESH:D008107 Liver Diseases Vitamin A 6.8616175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.2916762690
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 3.7417113696
MESH:D008171 Lung Diseases Vitamin A 4.1616863852
MESH:D008175 Lung Neoplasms alitretinoin 2.6516413115
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.4616827153
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma decitabine 3.4716505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008607 Mental Retardation Toluene 3.689294310
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4717261469
MESH:D019957 Motor Skills Disorders Toluene 5.359294310
MESH:D009101 Multiple Myeloma decitabine 7.9818172295
MESH:D009101 Multiple Myeloma Vitamin A 7.9816374440
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6816882708 18608210 19010910 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6817596541
MESH:D009369 Neoplasms alitretinoin 8.7416946489
MESH:D009369 Neoplasms decitabine 8.7417925555 19116145 19470736
MESH:D009369 Neoplasms Tretinoin 8.7416594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.909125849
MESH:D009436 Neural Tube Defects Tretinoin 7.889142499
MESH:D009436 Neural Tube Defects Vitamin A 7.8817400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D010051 Ovarian Neoplasms decitabine 5.0719259094 19331143
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0716936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.5019294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D017499 Porokeratosis alitretinoin 6.1816144296
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.9616877224
MESH:D012208 Rhabdomyosarcoma decitabine 11.3419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.3416283617 16116481
MESH:D012640 Seizures Toluene 3.796431079 9294310
MESH:D012871 Skin Diseases Vitamin A 3.3818709164
MESH:D012878 Skin Neoplasms Tretinoin 2.6516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms decitabine 2.5719037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4317997062
MESH:D013733 Testicular Diseases Toluene 5.1110514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms decitabine 7.5817967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7619087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms decitabine 13.4217785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.4216752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.3916146918 16960172 16175781
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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